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  • 1
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    Dissociation of antitumor potency from anthracycline cardiotoxicity in a doxorubicin analog (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-06-28
    Description: The search for new congeners of the leading anticancer drug doxorubicin has led to an analog that is approximately 1000 times more potent, noncardiotoxic at therapeutic dose levels, and non-cross-resistant with doxorubicin. The new anthracycline, 3'-deamino-3'-(3-cyano-4-morpholinyl)doxorubicin (MRA-CN), is produced by incorporation of the 3' amino group of doxorubicin in a new cyanomorpholinyl ring. The marked increase in potency was observed against human ovarian and breast carcinomas in vitro; it was not accompanied by an increase in cardiotoxicity in fetal mouse heart cultures. Doxorubicin and MRA-CN both produced typical cardiac ultrastructural and biochemical changes, but at equimolar concentrations. In addition, MRA-CN was not cross-resistant with doxorubicin in a variant of the human sarcoma cell line MES-SA selected for resistance to doxorubicin. Thus antitumor efficacy was dissociated from both cardiotoxicity and cross-resistance by this modification of anthracycline structure.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sikic, B I -- Ehsan, M N -- Harker, W G -- Friend, N F -- Brown, B W -- Newman, R A -- Hacker, M P -- Acton, E M -- CA 24543/CA/NCI NIH HHS/ -- CA 32250/CA/NCI NIH HHS/ -- CA 33303/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1985 Jun 28;228(4707):1544-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4012308" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Antineoplastic Agents ; Breast Neoplasms/drug therapy ; Cell Line ; Chemical Phenomena ; Chemistry ; Dose-Response Relationship, Drug ; Doxorubicin/adverse effects/*analogs & derivatives/therapeutic use ; Female ; Heart/drug effects ; Humans ; Isoenzymes ; L-Lactate Dehydrogenase/analysis ; Mice ; Myocardium/enzymology ; Ovarian Neoplasms/drug therapy ; Pregnancy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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    PAPER CURRENT
  • 2
    Electronic Resource
    Electronic Resource
    Simultaneous effect of macromixing and micromixing on growth processes (1971)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 17 (1971), S. 689-696 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Interaction of macromixing and micromixing in microbiological flow reactors based on a kinetic model of the Michaelis-Menten type has been treated by considering two general types of flow systems: the system of n continuous stirred-tank reactors in series (n-CSTR's in series) and the series combination of a plug-flow reactor and a continuous stirred-tank reactor. Systematic schemes to describe the micromixing conditions of a reactor system are presented. Additional micromixing states are considered besides those proposed by Kramers and those proposed by Zwietering if the systems are employed as empirical models of a flow system. When the number of stirred-reactor units in the system of n-CSTR's in series is small, micromixing has a significant effect on the growth processes. As the number of reactor units increases, the micromixing effect on the growth processes decreases. The effect of micromixing is also important for a system described by a series combination of a plug-flow reactor and a continuous stirred reactor. In addition, the exit concentrations from the system having the same residence time distribution and the same degree of segregation may be different from each other. Information obtained in this study is pertinent in the design of biological flow reactors and sewage treatment systems.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690170336
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  • 3
    Electronic Resource
    Electronic Resource
    Flow patterns and some holdup experimental data in trickle-bed reactors for foaming, nonfoaming, and viscous organic liquids (1978)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 24 (1978), S. 357-360 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690240230
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  • 4
    Electronic Resource
    Electronic Resource
    Isolation of a yeast-lyzing Arthrobacter species and the production of the lytic enzyme complex in batch and continuous-flow fermentors (1977)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 19 (1977), S. 879-899 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A gram-negative bacterium strongly lytic toward living cells of the food yeast Saccharomyces fragilis was isolated by continuous-flow enrichment from compost. The organism was identified as a species of Arthrobacter. The extracellular lytic enzyme complex produced by this bacterium contained β-1,3-glucanase, mannan mannohydrolase, and proteolytic activities. The polysaccharases were inducible by whole yeast cells. In chemostat cultures on chemically defined media, synthesis of the polysaccharases was very slight and only detectable at dilution rates below 0.02 hr-1. Enzyme production in defined media was not solely dependent on growth rate but also was influenced by the growth limiting substrate and the culture history. The production of individual depolymerases and of the lytic activity was studied in batch and chemostat cultures containing yeast as the limiting substrate. The maximum specific growth rate of the Arthrobacter under these conditions was 0.22 hr-1. β-1,3-Glucanase and proteolytic activities were synthesized by exponentially growing bacteria but maximum lytic titers did not develop until the specific growth rate was declining, at which time mannan mannohydrolase syntheses was induced. In yeast limited chemostats polysaccharase syntheses were greatest at the lowest dilution rates examined, namely 0.02 hr-1. Further optimization of enzyme production was achieved by feeding the Arthrobacter culture to a second-stage chemostat. A comparison of lytic enzyme productivities in batch and chemostat cultures has been made.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260190608
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  • 5
    Electronic Resource
    Electronic Resource
    Internal field emission in carbon black-loaded natural rubber vulcanizates (1962)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 6 (1962), S. 651-655 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The nonohmic behavior of carbon black-loaded natural rubber viilcanizates was studied. Three samples contained high-abrasion furnace black (HAF) in good, moderate, and poor dispersion. Another sample contained a good dispersion of medium thermal black (MT). The nonohmic behavior of the poor HAF dispersion and that of the MT dispersion could be interpreted as due to internal field emission acroM insulating gap widths of 2 and 2.5 μ. The existence of such gaps waa confirmed by electron micrographs. No clear evidence of internal field emission could be obtained for the good and moderate HAP dispersions where, according to electron micrographs, the gaps are much narrower. There is some indication that the degree of diapersion can be correlated with field emission characteristics.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1962.070062408
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  • 6
    Electronic Resource
    Electronic Resource
    Physikalische und chemische Relaxationsprozesse in Ethylen-Propylen-Elastomeren (1982)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 33 (1982), S. 413-420 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: With crosslinked ethylene-propylene elastomers SKEP-50 and SKEPT-50 six physical relaxation processes (λ relaxation) were established by relaxation spectroscopy. The higher values of the activation energy of the λ relaxation processes are assigned to intermolecular interaction caused by the third component, dicyclopentadiene, in the SKEPT terpolymer. The method presented allows to detect the multiplicity of chemical relaxation processes and its relationship to the network structure in elastomers crosslinked by sulfur and cumylperoxide.
    Notes: Mit der Methode der Relaxationsspektrometrie wurden an vernetzten Ethylen-Propylen-Elastomeren SKEP-50 und SKEPT-50 sechs physikalische Relaxationsprozesse (λ-Relaxation) gefunden. Die höheren Werte für die Aktivierungsenergie der λ-Relaxationsprozesse beim Terpolymer SKEPT hängen mit der durch die dritte Komponente, Dicyclopentadien, hervorgerufenen intermolekularen Wechselwirkung zusammen. Die Anwendung dieser Methode gestattet es, in den untersuchten schwefel-und cumylperoxidvernetzten Elastomeren die Multiplizität der chemischen Relaxationsprozesse und den Zusammenhang dieser Prozesse mit der Natur des Vulkanisationsnetzes der Elastomere aufzuzeigen.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1982.010330703
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  • 7
    Electronic Resource
    Electronic Resource
    Dendritic polymers: from aesthetic macromolecules to commercially interesting materials (1995)
    Weinheim : Wiley-Blackwell
    Acta Polymerica 46 (1995), S. 87-99 
    Details
    ISSN: 0323-7648
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: Dendritic polymers, perfectly branched dendrimers as well as hyperbranched materials, are discussed in some detail. The variety of the synthetic routes to perfect dendrimers and some highlights of the achieved structures document the rapid increase of activity in this field. Much information on growth, defects, dimensions, and properties of these globular macromolecules has be gained with special characterization techniques and their differences to linear polymers have become obvious. Hyperbranched polymers, which can be prepared in a one-step synthesis, cover almost the same structures as their perfect analogs and an interesting comparison of their properties can be made. High solubility and functionality, small dimensions, globular structure, and interesting viscosity behavior qualify both types of dendritic polymers for new applications. The transition from aesthetic macromolecules to commercially interesting materials is discussed with some examples.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/actp.1995.010460201
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  • 8
    Electronic Resource
    Electronic Resource
    The effect of micromixing on growth processes (1969)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 11 (1969), S. 181-205 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260110206
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  • 9
    Electronic Resource
    Electronic Resource
    Einwirkung von Chlorwasserstoffgas auf U3O8 (1953)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 273 (1953), S. 84-90 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Die Versuche der Chlorierung des U3O8 mittels trockenem Chlorwasserstoffgas haben gezeigt, daß der Chlorierungsprozeß schon bei verhältnismäßig niedrigen Temperaturen vonstatten geht und bei 1200° praktisch in 3 Stunden vollendet ist. Als Reaktionsprodukt entsteht UO2Cl2, das in Wasser leicht löslich ist. Gewisse Verluste entstehen wegen der thermischen Zersetzung des UO2Cl2 bzw. wegen des reversiblen Zersetzungsprozesses. Aus den Versuchen kann auch auf eine ökonomische Möglichkeit der Extraktion armer Uranerze geschlossen werden.
    Additional Material: 5 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19532730108
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  • 10
    Electronic Resource
    Electronic Resource
    Investigation of benzimidazoles: IIFor the preceding papers see Ref. 1. - the influence of substituents and solvents on the 1H and 13C NMR chemical shifts of 2-substituted 1,3-dimethylbenzimidazolium perchlorates (1981)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 17 (1981), S. 1-5 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The influence of substituents on 1H and 13C NMR chemical shifts of 2-substituted 1,3-dimethylbenzimidazolium perchlorates in different solvents has been investigated. It has been shown that the transmission of the electronic effects of the substituents in benzimidazoles and their quaternary salts are almost the same. The nature of the solvent influences only the intensity of the transmission of the electronic effects of substituents in 2-substituted 1,3-dimethylbenzimidazolium perchlorates.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270170102
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