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  • chloride channel  (2)
  • Chemistry  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Proteins of cytosol and amniotic fluid increase the voltage dependence of human type-1 porin (1996)
    Springer
    Journal of bioenergetics and biomembranes 28 (1996), S. 171-180 
    Details
    ISSN: 1573-6881
    Keywords: Porin ; VDAC ; anion channel ; chloride channel ; voltage dependence ; channel regulation ; plasma membrane ; regulatory protein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract Heat-stable proteins from human and porcine cytosol and human amniotic fluid were found to increase the voltage dependence of human type-1 porin reconstituted in planar phospholipid bilayers. Purification processes revealed that these regulatory molecules were characterized by anionic charge and apparent molecular weights of between 23 and 64 kDa. The human cytosol proteins exerted inhibitory activity only when added to the compartment with applied negative potential. The observed increase in voltage dependence of porin was due to the presence of specific proteins in cytosol and amniotic fluid, since human cerebral spinal fluid in comparable amounts had no significant effect on the channel properties. Furthermore, other anionic proteins and polypeptides investigated demonstrated no inhibitory activity, indicating that anionic charge alone could not mimic the molecular properties of the regulatory proteins. With respect to the well-documented expression of porin in the plasma membrane of various cells and species, the presented data give first clues for a biochemical regulation of the channel in this compartment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02110648
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  • 2
    Electronic Resource
    Electronic Resource
    Evidence for extra-mitochondrial localization of the VDAC/porin channel in eucaryotic cells (1992)
    Springer
    Journal of bioenergetics and biomembranes 24 (1992), S. 71-75 
    Details
    ISSN: 1573-6881
    Keywords: Porin ; VDAC ; plasma membrane ; cystic fibrosis ; chloride channel ; sodium channel ; long-term potentiation ; long-term depression ; endosymbiotic theory
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The expression of bacterial porin in outer membranes of gram-negative bacteria and of mitochondrial porin or voltage-dependent anion channel (VDAC) in outer mitochondrial membranes (OMM) of eucaryotic cells was demonstrated about 15 years ago. However, the expression of VDAC in the plasmalemma (PLM) of transformed human B lymphoblasts has recently been indicated by cytotoxicity and indirect immunofluorescence studies. New data suggest that the expression of VDAC may be even more widespread. Different cell types express porin channels in their PLM and in intracellular membranes other than OMM. The functional expression of these channels may differ in the various compartments since recent experiments have demonstrated that the voltage dependence and ion selectivity of mitochondrial VDAC may be altered by their interaction with modulators. The present paper proposes a unifying concept for the ion-selective channels of cell membranes, in particular, those whose regulation is affected in cystic fibrosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00769533
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  • 3
    Electronic Resource
    Electronic Resource
    An example of the thermal decomposition of a crystalline polymer  -  poly(l,6-bis(N-carbazolyl)-2,4-hexadiyne) (1992)
    New York : Wiley-Blackwell
    Die Makromolekulare Chemie 193 (1992), S. 389-397 
    Details
    ISSN: 0025-116X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: The thermal decomposition of poly(1,6-bis(N-carbazolyl)-2,4-hexadiyne) crystals, prepared by gamma radiation, was examined over a range of experimental conditions, the most important of which are temperature and crystal size. The only two significant products found were carbazole and to a lesser extent 9-methylcarbazole. Decomposition kinetics, which applied to the two observed autoacceleratory regions, was best fitted to an Avrami-Erofeyev equation with an exponent of two. The activation energy determined for the first autoacceleratory region was found to be higher than that determined for the second autoacceleratory region. A reaction mechanism is described based on stressinduced initiation, followed by either a molecular or a free-radical non-chain process. In an attempt to release stress, the polymer was observed to undergo sidegroup cleavage due to shearing of neighbouring polymer chains.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/macp.1992.021930211
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