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Digitale Medien

Evidence for extra-mitochondrial localization of the VDAC/porin channel in eucaryotic cells (1992)

Thinnes, Friedrich P.

Springer

Journal of bioenergetics and biomembranes 24 (1992), S. 71-75

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ISSN: 1573-6881

Schlagwort(e): Porin ; VDAC ; plasma membrane ; cystic fibrosis ; chloride channel ; sodium channel ; long-term potentiation ; long-term depression ; endosymbiotic theory

Quelle: Springer Online Journal Archives 1860-2000

Thema: Biologie , Chemie und Pharmazie , Physik

Notizen: Abstract The expression of bacterial porin in outer membranes of gram-negative bacteria and of mitochondrial porin or voltage-dependent anion channel (VDAC) in outer mitochondrial membranes (OMM) of eucaryotic cells was demonstrated about 15 years ago. However, the expression of VDAC in the plasmalemma (PLM) of transformed human B lymphoblasts has recently been indicated by cytotoxicity and indirect immunofluorescence studies. New data suggest that the expression of VDAC may be even more widespread. Different cell types express porin channels in their PLM and in intracellular membranes other than OMM. The functional expression of these channels may differ in the various compartments since recent experiments have demonstrated that the voltage dependence and ion selectivity of mitochondrial VDAC may be altered by their interaction with modulators. The present paper proposes a unifying concept for the ion-selective channels of cell membranes, in particular, those whose regulation is affected in cystic fibrosis.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1007/BF00769533

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Digitale Medien

An example of the thermal decomposition of a crystalline polymer - poly(l,6-bis(N-carbazolyl)-2,4-hexadiyne) (1992)

Bradner, Friedrich P. ; Shapiro, Jacob S.

New York : Wiley-Blackwell

Die Makromolekulare Chemie 193 (1992), S. 389-397

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ISSN: 0025-116X

Schlagwort(e): Chemistry ; Polymer and Materials Science

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie , Physik

Notizen: The thermal decomposition of poly(1,6-bis(N-carbazolyl)-2,4-hexadiyne) crystals, prepared by gamma radiation, was examined over a range of experimental conditions, the most important of which are temperature and crystal size. The only two significant products found were carbazole and to a lesser extent 9-methylcarbazole. Decomposition kinetics, which applied to the two observed autoacceleratory regions, was best fitted to an Avrami-Erofeyev equation with an exponent of two. The activation energy determined for the first autoacceleratory region was found to be higher than that determined for the second autoacceleratory region. A reaction mechanism is described based on stressinduced initiation, followed by either a molecular or a free-radical non-chain process. In an attempt to release stress, the polymer was observed to undergo sidegroup cleavage due to shearing of neighbouring polymer chains.

Zusätzliches Material: 3 Ill.