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  • Chemistry  (7)
  • Cell Differentiation  (1)
  • Chromatography, High Pressure Liquid/methods  (1)
  • 1
    Digitale Medien
    Digitale Medien
    Indole derivatization procedures for electron capture negative chemical ionization mass spectrometry: Identification of 1-methyl-1,2,3,4-tetrahydro-β-carboline in rat brain and lung (1989)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 18 (1989), S. 247-252 
    Details
    ISSN: 0887-6134
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Procedures have been developed for the isolation of pharmacologically active indole compounds from biological samples and for the introduction of electron-capturing groups, pentafluorobenzyl and trifluoroacetyl, onto the indole nitrogen atom. The resulting derivatives have good gas chromatographic properties and strong electron affinities which make them highly suitable for detection capture negative chemical ionization mass spectrometry. These procedures were used to identify 1-methyl-1,2,3,4-tetrahydro-β-carboline as a component of rat brain and lung.
    Zusätzliches Material: 5 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200180407
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  • 2
    Digitale Medien
    Digitale Medien
    Measurement of phenylacetic acid in cerebrospinal fluid and plasma using combined gas chromatography/electron capture chemical ionization mass spectrometry (1988)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 17 (1988), S. 213-219 
    Details
    ISSN: 1052-9306
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Details are presented of an ultra-sensitive gas chromatographic/mass spectrometric assay for phenylacetic acid in plasma and cerebrospinal fluid based on measurements of the relative intensities of the carboxylate anions, derived from the penta- and tetraflourobenzyl esters under electron capture chemical ionization conditions, of unlabeled and a (13C2)-labeled internal standard. The limits of detection for the penta- and tetrafluorobenzyl esters are 0.85 and 4.0 pg respectively, and the assay is capable of measuring phenylacetic acid concentrations in samples as small as 20 μl of CSF and plasma. The penta- and tetrafluorobenzyl esters are chromatographically separated on the gas chromatograph column, which allows for their co-injection and independent measurement from the same chromatogram.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200170310
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  • 3
    Digitale Medien
    Digitale Medien
    6-Hydroxymethtryptoline is naturally occurring in mammalian urine: Identification by combined chiral capillary gas chromatography and high resolution mass spectrometry (1986)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 13 (1986), S. 469-472 
    Details
    ISSN: 1052-9306
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: The tricyclic indole derivative 6-hydroxymethtryptoline (7-hydroxy-1-methyltetrahydro-β-carboline) was identified as a normal constituent of human and cat urine. The identification was based on the correct retention time on a chiral capillary gas chromatographic column and on selected ion monitoring of the molecular ion with the mass spectrometer set at high resolving power (RP 10 000). The quantitation utilized a 13C-labeled analog as internal standard and demonstrated levels of 135 ± 35 and 174 ± 42 (pmol ml-1, mean ±SEM) for the S(-) and R(+) enantiomers, respectively, in human urine. In cat urine, the levels were 203 ± 55 and 108 ± 44 (pmol ml-1, mean ± SEM) for the S(-) and R(+) enantiomers, respectively. In human urine, the compound occurred predominantly in a conjugated form while in cat urine the free compound predominated. It was concluded that 6-hydroxymethtryptoline is naturally occurring in mammalian urine and that it most likely constitutes a metabolite of endogenous methtryptoline (1-methyltetrahydro-β-carboline).
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200130903
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  • 4
    Digitale Medien
    Digitale Medien
    Gas chromatography/electron impact mass spectrometry, fast atom bombardment mass spectrometry, mass-analyzed ion kinetic energy spectroscopy and B/E linked scan analysis of triaryl phosphates and triethylene glycol fatty acid esters (1990)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 19 (1990), S. 151-158 
    Details
    ISSN: 1052-9306
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Tris(isopropylphenyl/phenyl) phosphates and triethylene glycol dicaprate/caprylate mixtures of typical industrial compositions have been analyzed by fast atom bombardment (FAB) mass spectrometry, FAB collisional activation (CA) mass-analyzed ion kinetic energy spectroscopy and FAB/electron impact (EI) CA B/E linked scans. Data obtained by these state-of-the-art methodologies are compared qualitatively and semi-quantitatively with those provided by classical gas chromatography (GC)/EI MS. To identify the plasticizers in cases of suspected contamination, GC/EI MS still appears to be the method of choice whenever ultimate sensitivity and specificity are needed. In cases where these requirements are less demanding, FAB mass spectrometry and FAB tandem mass spectrometry may be sufficient and more convenient.
    Zusätzliches Material: 8 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200190310
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  • 5
    Digitale Medien
    Digitale Medien
    Special feature: Perspective. Mass spectrometric peptide and protein charting (1995)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 30 (1995), S. 519-530 
    Details
    ISSN: 1076-5174
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie , Physik
    Notizen: Six years after coining the term ‘mass spectrometric (MS) peptide charting’ for the component analysis of peptide mixtures in a whole tissue, body fluid, or an extract thereof, we offer our current perspective of this field. Matrixassisted laser desorption/ionization and electrospray ionization have replaced plasma desorption and fast atom bombardment as ionization methods of choice. At the same time, the upper mass range has been extended to now include most peptides and proteins of interest to research on cell-cell communication. In addition to qualitative aspects, quantitative applications of MS charting have become important. In combination with new database search algorithms, on-line liquid chromatography-tandem mass spectrometry promises greater dividends from MS charting than are achievable with molecular mass matching alone. We discuss what is and is not yet possible, and consider foreseeable means for overcoming current limitations. Our intent is to encourage researchers in the biological and medical sciences to take advantage of this powerful methodology in their various fields of endeavor.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/jms.1190300402
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  • 6
    Digitale Medien
    Digitale Medien
    A selective ion monitoring assay for probenecidAbbreviations: DBSB = m-(di-isobutylsulfamyl)benzoic acid; PFPA = pentafluoropropionic anhydride; PFP = pentafluoropropyl; DOPAC = 3,4-dihydroxyphenylacetic acid; MHPG = 3-methoxy-4-H hydroxyphenylethylene glycol; HVA = homovanillic acid; 5-HIAA = 5-hydroxyindoleacetic acid. (1978)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 5 (1978), S. 317-320 
    Details
    ISSN: 0306-042X
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A selective ion monitoring assay for probenecid (p-(dipropylsulfamyl)benzoic acid) using m-(di-isobutylsulfamyl)benzoic acid as an internal standard is described. The method has been applied to the determination of probenecid concentrations in human cerebrospinal fluid and lends itself to incroporation into the selective ion monitoring procedures used to quantitate other acidic and neutral compounds in such samples.
    Zusätzliches Material: 3 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200050408
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  • 7
    Digitale Medien
    Digitale Medien
    Deuterated peptides: Platinum catalyzed exchange labeling of leucine enkephalin and related peptides (1983)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 10 (1983), S. 463-470 
    Details
    ISSN: 0306-042X
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: Platinum catalyzed hydrogen-deuterium exchange labeling of phenylalanine and tyrosine containing peptides in deuterium oxide is exemplified by the preparation of deuterium labeled leucine enkephalin and related peptides. NMR and mass spectral evidence indicates that the side chains of the aromatic residues are the sites of label incorporation. Time course studies with N-acetyltyrosine and tyrosyl-glycine suggest that the exchange of the aromatic protons occurs most rapidly followed by exchange of the benzylic protons adjacent to the aromatic ring.
    Zusätzliches Material: 6 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200100805
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  • 8
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    Unbekannt
    Structure of the cell wall anchor of surface proteins in Staphylococcus aureus (1995)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 1995-04-07
    Beschreibung: Many surface proteins are anchored to the cell wall of Gram-positive bacteria and are involved in the pathogenesis of these organisms. A hybrid molecule was designed that, when expressed in Staphylococcus aureus, was anchored to the cell wall and could be released by controlled enzymatic digestion. By a combination of molecular biology and mass spectrometry techniques, the structure of the cell wall anchor of surface proteins in S. aureus was revealed. After cleavage of surface proteins between threonine and glycine of the conserved LPXTG motif, the carboxyl of threonine is amide-linked to the free amino group of the pentaglycine crossbridge in the staphylococcal cell wall.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schneewind, O -- Fowler, A -- Faull, K F -- AI 33985/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1995 Apr 7;268(5207):103-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Microbiology and Immunology, University of California School of Medicine, Los Angeles 90024, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/7701329" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Amino Acid Sequence ; Bacterial Proteins/*chemistry ; Base Sequence ; Carrier Proteins/chemistry ; Cell Wall/*chemistry ; Chromatography, Affinity ; Chromatography, High Pressure Liquid/methods ; Electrophoresis, Polyacrylamide Gel ; Maltose-Binding Proteins ; Membrane Proteins/*chemistry ; Molecular Sequence Data ; Recombinant Fusion Proteins/chemistry ; Staphylococcal Protein A/chemistry ; Staphylococcus aureus/*chemistry
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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  • 9
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    Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension (2007)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2007-02-17
    Beschreibung: The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Curtis, Maurice A -- Kam, Monica -- Nannmark, Ulf -- Anderson, Michelle F -- Axell, Mathilda Zetterstrom -- Wikkelso, Carsten -- Holtas, Stig -- van Roon-Mom, Willeke M C -- Bjork-Eriksson, Thomas -- Nordborg, Claes -- Frisen, Jonas -- Dragunow, Michael -- Faull, Richard L M -- Eriksson, Peter S -- New York, N.Y. -- Science. 2007 Mar 2;315(5816):1243-9. Epub 2007 Feb 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17303719" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Apoptosis ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Cell Differentiation ; Cell Movement ; Cell Nucleus/chemistry/ultrastructure ; Cell Shape ; Ependyma/cytology ; Eye Proteins/genetics ; Homeodomain Proteins/genetics ; Humans ; Lateral Ventricles/anatomy & histology/*cytology ; Magnetic Resonance Imaging ; Microscopy, Electron ; Microtubule-Associated Proteins/genetics ; Nerve Tissue Proteins/genetics ; Neural Cell Adhesion Molecule L1/analysis ; Neurons/chemistry/cytology/*physiology/ultrastructure ; Neuropeptides/genetics ; Olfactory Bulb/anatomy & histology/*cytology ; Olfactory Pathways/anatomy & histology/*cytology ; Paired Box Transcription Factors/genetics ; Prosencephalon/anatomy & histology/*cytology ; Repressor Proteins/genetics ; Sialic Acids/analysis ; Stem Cells/chemistry/cytology/*physiology/ultrastructure ; Tubulin/analysis
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
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