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  • 1
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    Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress (1997)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1997-09-12
    Description: Variations in maternal care affect the development of individual differences in neuroendocrine responses to stress in rats. As adults, the offspring of mothers that exhibited more licking and grooming of pups during the first 10 days of life showed reduced plasma adrenocorticotropic hormone and corticosterone responses to acute stress, increased hippocampal glucocorticoid receptor messenger RNA expression, enhanced glucocorticoid feedback sensitivity, and decreased levels of hypothalamic corticotropin-releasing hormone messenger RNA. Each measure was significantly correlated with the frequency of maternal licking and grooming (all r's 〉 -0.6). These findings suggest that maternal behavior serves to "program" hypothalamic-pituitary-adrenal responses to stress in the offspring.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Liu, D -- Diorio, J -- Tannenbaum, B -- Caldji, C -- Francis, D -- Freedman, A -- Sharma, S -- Pearson, D -- Plotsky, P M -- Meaney, M J -- New York, N.Y. -- Science. 1997 Sep 12;277(5332):1659-62.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Developmental Neuroendocrinology Laboratory, Douglas Hospital Research Center, McGill University, Montreal, Canada H4H 1R3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9287218" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenocorticotropic Hormone/blood ; Animals ; Animals, Newborn ; Corticosterone/blood/pharmacology ; Corticotropin-Releasing Hormone/genetics ; Feedback ; Female ; Gene Expression Regulation ; Grooming ; Handling (Psychology) ; Hippocampus/*physiology ; Hypothalamo-Hypophyseal System/*physiology ; *Maternal Behavior ; Pituitary-Adrenal System/*physiology ; RNA, Messenger/genetics/metabolism ; Rats ; Receptors, Glucocorticoid/genetics/*metabolism ; Stress, Physiological/*physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Phenylalanine depletion for the management of phenylketonuria: use of enzyme reactors with immobilized enzymes (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-01
    Description: Multitubular enzyme reactors with immobilized phenylalanine ammonia lyase were tested in vitro and in vivo for depletion of phenylalanine in circulating blood. Sustained reduction of phenylalanine was achieved in less than 30 minutes. A 50% decrease of phenylalanine was obtained with a 2-hour application of enzyme reactors and was maintained for more than 2 days. Similar enzyme reactors have therapeutic potential for temporary management of phenylketonuric patients when their circulating phenylalanine becomes exceedingly high because of infection, fever, or pregnancy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ambrus, C M -- Ambrus, J L -- Horvath, C -- Pedersen, H -- Sharma, S -- Kant, C -- Mirand, E -- Guthrie, R -- Paul, T -- New York, N.Y. -- Science. 1978 Sep 1;201(4358):837-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/567372" target="_blank"〉PubMed〈/a〉
    Keywords: Ammonia-Lyases/*therapeutic use ; Animals ; *Disease Models, Animal ; Dogs ; Enzymes, Immobilized/*therapeutic use ; Extracorporeal Circulation ; Humans ; Phenylalanine/blood ; Phenylalanine Ammonia-Lyase/*therapeutic use ; Phenylketonurias/*therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Diversity of circumsporozoite antigen genes from two strains of the malarial parasite Plasmodium knowlesi (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-08-23
    Description: The complete nucleotide sequence of the coding region of the circumsporozoite antigen gene (CS gene) of the Nuri strain of the malarial parasite Plasmodium knowlesi is presented. The gene from the Nuri strain exhibits a novel form of sequence diversity when compared to the CS gene from the H strain. Instead of the 12 tandem repeating 36-base pair units of the H strain, the Nuri strain contains 16 tandem repeating 27-base pair units of a different nucleotide sequence that encodes a different repeating peptide. In contrast, the 5' and 3' coding and noncoding sequences flanking the repeats are 98 percent conserved in both strains.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sharma, S -- Svec, P -- Mitchell, G H -- Godson, G N -- 1 R01 AI21496-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1985 Aug 23;229(4715):779-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4023712" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigens, Protozoan/*genetics ; Antigens, Surface/genetics ; Base Sequence ; Genes ; Molecular Sequence Data ; Plasmodium/*genetics/immunology ; Protozoan Proteins/*genetics ; Repetitive Sequences, Nucleic Acid
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Expression of the major surface antigen of Plasmodium knowlesi sporozoites in yeast (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-17
    Description: The circumsporozite protein, a surface antigen of the sporozoite stage of the monkey malarial parasite Plasmodium knowlesi, was expressed in the yeast Saccharomyces cerevisiae by using an expression vector containing the 5' regulatory region of the yeast alcohol dehydrogenase I gene. It was necessary to eliminate the entire 5' upstream region of the parasite DNA to obtain the expression of this protein. Only the circumsporozoite precursor was produced by the yeast transformants, as detected by immunoblotting. About 55 and 20 percent of the circumsporozoite protein produced in yeast was associated wtih the 25,000 g and 150,000 g particulate fractions, respectively. The protein could be solubilized in Triton X-100 and was stable in solubilized extracts.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sharma, S -- Godson, G N -- 1 R01 AI21496-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1985 May 17;228(4701):879-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3890178" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antigens, Protozoan/*genetics ; Antigens, Surface/*genetics ; Cloning, Molecular ; DNA, Recombinant ; Genes ; Molecular Weight ; Plasmodium/genetics/*immunology ; Protein Precursors/biosynthesis/genetics ; Protozoan Proteins/*genetics ; Saccharomyces cerevisiae/*genetics ; Transformation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    On the thickness and spatial distribution of a fluoropolymer film deposited by solution dipping (1980)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 25 (1980), S. 211-222 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Poly-1H,1H-pentadecafuorooctyl methacrylate is a barrier compound used to prevent silicone oil from creeping to relay contacts. It is essentially a methyl methacrylate polymer with a fluorocarbon side chain substituted for one of the methyl hydrogens. It is applied by dipping the part into a solution, with Freon TF as the solvent and the fluorocarbon polymer as the solute. This work considers the spatial distribution of the resulting film of barrier compound when it is deposited in this manner. The specific variables considered are concentration and withdrawal velocity. The samples were withdrawn from the solution with velocity perpendicular to the surface, and we show that the macrosopic uniformity and thickness of the film is dependent on this velocity. There exists a critical velocity (dependent on concentration) above which the film is nonuniform and below which the film is macroscopically uniform. Below the critical velocity, the thickness varies with velocity with approximately a v2/3 dependence. The critical velocity is about 13 mm/sec for a concentration of 0.2%. For macroscopically uniform films, a microscopic nonunitormity exists with a coverage of about 1/4 for an average film thickness of 90 Å.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1980.070250207
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  • 6
    Electronic Resource
    Electronic Resource
    The effect of stretching conditions on properties of amorphous polyethylene terephthalate film (1987)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 34 (1987), S. 2231-2247 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The effect of stretching condition on stress-induced crystallization of amorphous polyethylene terephthalate (PET) film has been studied. Cast PET film was stretched at 85°C with stretching rates ranging from 100% per minute to 600% per minute for various stretching ratios. The stretched film samples were annealed at 140°C both under tension as well as under relaxed conditions. Tensile properties were determined using Instron Tensile Tester and results were compared. Tenacity, yield stress, and initial modulus were found to increase while elongation at break decreased with the increase in stretching rate. The degree of crystallinity was measured by x-ray diffraction as well as density methods. Birefringence and crystalline orientation factor values were determined experimentally and using these, amorphous orientation factor values were calculated. Birefringence, crystalline orientation and amorphous orientation values were found to increase with the increase in stretching rate. These studies showed that at low stretching rates a significant amount of relaxation takes place, resulting in lower orientation and strength. On the other hand, at higher stretching rates relaxation is minimized thus providing high orientation and strength. Upon annealing the crystallinity values increased as expected, however the trend of orientation and mechanical properties with respect to stretching rate was similar to those of unannealed films.
    Additional Material: 17 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1987.070340615
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  • 7
    Electronic Resource
    Electronic Resource
    Drag coefficient and velocity of rise of a single collasping two-phase bubble (1997)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 43 (1997), S. 1955-1963 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: The velocity of rise and the drag of a single vapor bubble collapsing in another immiscible liquid were measured experimentally. During the process of collapse, the dispersed-phase vapor bubble was transformed to a two-phase bubble with condensate accumulating at the rear of the two-phase bubble and vapor at its top. Such a configuration of a two-phse bubble is commonly known as a drobble. Experimental data for the six pairs of liquids covered a range of drobble (two-phase bubble) Reynolds numbers from 0.003 to 3,000. Two regimes of drobble movement were encountered. In the first regime (Re 〈 100), the drobble maintained its sphericity, and the observed drag was less than the solid-sphere drag predicted by the established solid sphere or Hadamard et al. fluid-sphere drag models. In the second regime, the drobble was deformed and oscillated; the observed drag departed suddenly from predictions of spherical models and increased with increasing Reynolds numbers. The critical Reynolds number covered a range from 100 to 1,000. Empirical models for drobble velocity and drag coefficient are derived.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690430805
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  • 8
    Electronic Resource
    Electronic Resource
    Chemistry of Substituted Sulphuric Acids. X. Acids and Bases in Methanesulphuric Acid Solvent System (1980)
    Weinheim : Wiley-Blackwell
    Zeitschrift für anorganische Chemie 471 (1980), S. 203-207 
    Details
    ISSN: 0044-2313
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Chemie substituierter Schwefelsäuren. X. Lösungen von Säuren und Basen in MethansulfonsäurenMethansulfonsäure ist schwächer als Schwefelsäure. Eine Zahl von anorganischen protonischen Säuren wirken in Methansulfonsäure gelöst als Säuren, während starke Basen vollständig protoniert werden. Säure-Base-Titrationen in Methansulfonsäure zeigen bei starken Säuren, daß die elektrische Leitung über CH3SO3H2+ - und CH3SO3- - Ionen erfolgt. Leitfähigkeitsmessungen zeigen die Reihenfolge der Säurestärken, s. Abstract.
    Notes: Methanesulphuric acid is weaker than sulphuric acid. A number of inorganic protonic acids act as acids in it while the strong bases are fully protonated. The acid-base titrations in it with strong acids indicate that the bulk of the current is carried by CH3SO3H2+ and CH3SO3- ions. The conductance measurements indicate that the order of the acid strength is: H[B(HSO4)4] 〉 HSO3F 〉 H2S2O7 〉 HAs(HSO4)4 〉 HSO3Cl 〉 H2SO4 〉 HX (X=Br 〉 Cl) 〉 H2SeO4.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/zaac.19804710123
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  • 9
    Electronic Resource
    Electronic Resource
    Effect of thermal treatment on the electrothermographic and electrical properties of poly(acrylonitrile butadiene styrene) (1985)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 130 (1985), S. 91-97 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: Es wurden Untersuchungen zum elektrothermographischen und zum Leitfähigkeitsverhalten von Poly(Acrylnitril-Butadien-Styrol) (ABS) nach unterschiedlichen thermischen Vorbehandlungen durchgeführt. Die spezifischen Widerstände von bei 50°C gelagerten ABS-Platten erwiesen sich als klein (∼ 1015 Ω · cm). Auch die Ladungsaufnahme und die Ladungsspeicherung waren schlecht. Der Grund dafür ist die Adsorption von Wassermolekülen. Werden die Platten bei 100°C oder mehr für 5 h thermisch beansprucht, zeigen sie erhöhte spezifische Widerstände (∼ 1017 Ω· cm bei 50°C) und haben deshalb eine bessere Ladungsaufnahme und -speicherung. Sowohl Umwelt- und Lagerungsbedingungen als auch eine thermische Behandlung während der Herstellung der Platten haben unterhalb 110°C keinen Einfluß auf die Temperaturabhängigkeit der spezifische Widerstände.
    Notes: Studies on the electrothermographic and conductivity behaviour of poly(acrylonitrile butadiene styrene) (ABS) films of different thermal pretreatments were carried out. The resistivity in ABS layers stored at 50°C was found to be low (∼ 1015 Ω · cm). The charge acceptance and its retention also is poor. The reason for that is the adsorption of water molecules. The layers, when thermally treated at 100°C or more for 5 h, show an enhanced resistivity (∼ 1017 Ω · cm at 50°C) and hence an improvement in charge acceptance as well as in charge retention. Environmental and storage conditions as well as thermal treatment during layer preparations have no effect on the temperature dependence of the resistivity beyond 110°C.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1985.051300107
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  • 10
    Electronic Resource
    Electronic Resource
    Raman spectral study of solid and dissolved poly(vinyl alcohol) and ethylene-vinyl alcohol copolymer (1994)
    Bognor Regis [u.a.] : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Physics 32 (1994), S. 1163-1174 
    Details
    ISSN: 0887-6266
    Keywords: poly(vinyl alcohol) ; raman spectroscopy ; polymer ; aqueous solution ; Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: We have measured the Raman spectra of ethylene-vinyl alcohol copolymer (EVOH) and poly(vinyl alcohol) (PVOH). Spectra of 88% hydrolyzed PVOH were examined from the partially crystalline solid, from PVOH dissolved in both H2O and D2O, and from films precipitated from these solutions. The spectrum in H2O differs from that of the starting material by disappearance of sharp bands having Raman shift values of 1146 and 1093 cm-1, strengthening of a band near 915 cm-1, decrease in frequency of bands at 480, 1356, and 1441 cm-1, and increase in frequency of bands at 369, 413, 1023, 1371, and 2910 cm-1. The spectrum of the film shows partial reversal of these trends. With D2O as the solvent, the band shifts are slightly different from those listed above and new bands appear. These changes are indicative of loss of crystallinity, change in stereochemistry, and partial deuteration of hydroxyl during dissolution of this PVOH sample at room temperature. © 1994 John Wiley & Sons, Inc.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/polb.1994.090320704
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