Publication Date:
2007-02-17
Description:
The rostral migratory stream (RMS) is the main pathway by which newly born subventricular zone cells reach the olfactory bulb (OB) in rodents. However, the RMS in the adult human brain has been elusive. We demonstrate the presence of a human RMS, which is unexpectedly organized around a lateral ventricular extension reaching the OB, and illustrate the neuroblasts in it. The RMS ensheathing the lateral olfactory ventricular extension, as seen by magnetic resonance imaging, cell-specific markers, and electron microscopy, contains progenitor cells with migratory characteristics and cells that incorporate 5-bromo-2'-deoxyuridine and become mature neurons in the OB.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Curtis, Maurice A -- Kam, Monica -- Nannmark, Ulf -- Anderson, Michelle F -- Axell, Mathilda Zetterstrom -- Wikkelso, Carsten -- Holtas, Stig -- van Roon-Mom, Willeke M C -- Bjork-Eriksson, Thomas -- Nordborg, Claes -- Frisen, Jonas -- Dragunow, Michael -- Faull, Richard L M -- Eriksson, Peter S -- New York, N.Y. -- Science. 2007 Mar 2;315(5816):1243-9. Epub 2007 Feb 15.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anatomy with Radiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17303719" target="_blank"〉PubMed〈/a〉
Keywords:
Apoptosis
;
Basic Helix-Loop-Helix Transcription Factors/genetics
;
Cell Differentiation
;
Cell Movement
;
Cell Nucleus/chemistry/ultrastructure
;
Cell Shape
;
Ependyma/cytology
;
Eye Proteins/genetics
;
Homeodomain Proteins/genetics
;
Humans
;
Lateral Ventricles/anatomy & histology/*cytology
;
Magnetic Resonance Imaging
;
Microscopy, Electron
;
Microtubule-Associated Proteins/genetics
;
Nerve Tissue Proteins/genetics
;
Neural Cell Adhesion Molecule L1/analysis
;
Neurons/chemistry/cytology/*physiology/ultrastructure
;
Neuropeptides/genetics
;
Olfactory Bulb/anatomy & histology/*cytology
;
Olfactory Pathways/anatomy & histology/*cytology
;
Paired Box Transcription Factors/genetics
;
Prosencephalon/anatomy & histology/*cytology
;
Repressor Proteins/genetics
;
Sialic Acids/analysis
;
Stem Cells/chemistry/cytology/*physiology/ultrastructure
;
Tubulin/analysis
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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