Publication Date:
2003-12-06
Description:
Cell migration is a highly integrated multistep process that orchestrates embryonic morphogenesis; contributes to tissue repair and regeneration; and drives disease progression in cancer, mental retardation, atherosclerosis, and arthritis. The migrating cell is highly polarized with complex regulatory pathways that spatially and temporally integrate its component processes. This review describes the mechanisms underlying the major steps of migration and the signaling pathways that regulate them, and outlines recent advances investigating the nature of polarity in migrating cells and the pathways that establish it.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ridley, Anne J -- Schwartz, Martin A -- Burridge, Keith -- Firtel, Richard A -- Ginsberg, Mark H -- Borisy, Gary -- Parsons, J Thomas -- Horwitz, Alan Rick -- New York, N.Y. -- Science. 2003 Dec 5;302(5651):1704-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, London W1W 7BS, UK.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/14657486" target="_blank"〉PubMed〈/a〉
Keywords:
Actin Cytoskeleton/physiology
;
Animals
;
Cell Adhesion
;
*Cell Movement
;
Cell Polarity
;
Humans
;
Integrins/physiology
;
Models, Biological
;
Proteins/metabolism
;
Pseudopodia/physiology
;
*Signal Transduction
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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