Publication Date:
1998-02-28
Description:
Hippocampal "place cells" fire selectively when an animal is in a specific location. The fine-tuning and stability of place cell firing was compared in two types of mutant mice with different long-term potentiation (LTP) and place learning impairments. Place cells from both mutants showed decreased spatial selectivity. Place cell stability was also deficient in both mutants and, consistent with the severities in their LTP and spatial learning deficits, was more affected in mice with a point mutation [threonine (T) at position 286 mutated to alanine (A)] in the alpha calmodulin kinase II (alphaCaMKIIT286A) than in mice deficient for the alpha and Delta isoforms of adenosine 3'5'-monophosphate-responsive element binding proteins (CREBalphaDelta-). Thus, LTP appears to be important for the fine tuning and stabilization of place cells, and these place cell properties may be necessary for spatial learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cho, Y H -- Giese, K P -- Tanila, H -- Silva, A J -- Eichenbaum, H -- AG13622/AG/NIA NIH HHS/ -- MH51570/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1998 Feb 6;279(5352):867-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Psychology, Boston University, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9452387" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Calcium-Calmodulin-Dependent Protein Kinase Type 2
;
Calcium-Calmodulin-Dependent Protein Kinases/deficiency/genetics
;
Cues
;
Cyclic AMP Response Element-Binding Protein/genetics/metabolism
;
Hippocampus/cytology/*physiology
;
*Learning
;
*Long-Term Potentiation
;
Maze Learning
;
Mice
;
Mice, Inbred C57BL
;
Mice, Mutant Strains
;
Orientation
;
Point Mutation
;
Pyramidal Cells/physiology
;
*Space Perception
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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