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  • *Alcohol Drinking/drug therapy  (1)
  • Anthropogenic impact  (1)
  • American Association for the Advancement of Science (AAAS)  (1)
  • American Geophysical Union  (1)
  • Blackwell Publishing Ltd
  • Paleontological Society
  • American Meteorological Society (AMS)
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  • American Association for the Advancement of Science (AAAS)  (1)
  • American Geophysical Union  (1)
  • Blackwell Publishing Ltd
  • Paleontological Society
  • American Meteorological Society (AMS)
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  • 1
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    Neurokinin 1 receptor antagonism as a possible therapy for alcoholism (2008)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2008-02-16
    Description: Alcohol dependence is a major public health challenge in need of new treatments. As alcoholism evolves, stress systems in the brain play an increasing role in motivating continued alcohol use and relapse. We investigated the role of the neurokinin 1 receptor (NK1R), a mediator of behavioral stress responses, in alcohol dependence and treatment. In preclinical studies, mice genetically deficient in NK1R showed a marked decrease in voluntary alcohol consumption and had an increased sensitivity to the sedative effects of alcohol. In a randomized controlled experimental study, we treated recently detoxified alcoholic inpatients with an NK1R antagonist (LY686017; n = 25) or placebo (n = 25). LY686017 suppressed spontaneous alcohol cravings, improved overall well-being, blunted cravings induced by a challenge procedure, and attenuated concomitant cortisol responses. Brain functional magnetic resonance imaging responses to affective stimuli likewise suggested beneficial LY686017 effects. Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉George, David T -- Gilman, Jodi -- Hersh, Jacqueline -- Thorsell, Annika -- Herion, David -- Geyer, Christopher -- Peng, Xiaomei -- Kielbasa, William -- Rawlings, Robert -- Brandt, John E -- Gehlert, Donald R -- Tauscher, Johannes T -- Hunt, Stephen P -- Hommer, Daniel -- Heilig, Markus -- Intramural NIH HHS/ -- New York, N.Y. -- Science. 2008 Mar 14;319(5869):1536-9. doi: 10.1126/science.1153813. Epub 2008 Feb 14.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/18276852" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; *Alcohol Drinking/drug therapy ; Alcoholism/*drug therapy ; Animals ; Behavior, Addictive/drug therapy ; Brain/drug effects/physiology ; Emotions/drug effects ; Ethanol/administration & dosage/pharmacology ; Female ; Humans ; Hydrocortisone/blood ; Magnetic Resonance Imaging ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; *Neurokinin-1 Receptor Antagonists ; Pyridines/administration & dosage/pharmacology/*therapeutic use ; Receptors, Neurokinin-1/deficiency/genetics/*physiology ; Triazoles/administration & dosage/pharmacology/*therapeutic use
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Wave generation, dissipation, and disequilibrium in an embayment with complex bathymetry (2019)
    American Geophysical Union
    Details
    Publication Date: 2022-10-20
    Description: Author Posting. © American Geophysical Union, 2018. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Wave generation, dissipation, and disequilibrium in an embayment with complex bathymetry. Journal of Geophysical Research-Oceans, 123(11), (2018): 7856-7876, doi:10.1029/2018JC014381.
    Description: Heterogeneous, sharply varying bathymetry is common in estuaries and embayments, and complex interactions between the bathymetry and wave processes fundamentally alter the distribution of wave energy. The mechanisms that control the generation and dissipation of wind waves in an embayment with heterogeneous, sharply varying bathymetry are evaluated with an observational and numerical study of the Delaware Estuary. Waves in the lower bay depend on both local wind forcing and remote wave forcing from offshore, but elsewhere in the estuary waves are controlled by the local winds and the response of the wavefield to bathymetric variability. Differences in the wavefield with wind direction highlight the impacts of heterogeneous bathymetry and limited fetch. Under the typical winter northwest wind conditions waves are fetch‐limited in the middle estuary and reach equilibrium with local water depth only in the lower bay. During southerly wind conditions typical of storms, wave energy is near equilibrium in the lower bay, and midestuary waves are attenuated by the combination of whitecapping and bottom friction, particularly over the steep, longitudinal shoals. Although the energy dissipation due to bottom friction is generally small relative to whitecapping, it becomes significant where the waves shoal abruptly due to steep bottom topography. In contrast, directional spreading keeps wave heights in the main channel significantly less than local equilibrium. The wave disequilibrium in the deep navigational channel explains why the marked increase in depth by dredging of the modern channel has had little impact on wave conditions.
    Description: Funding was provided by National Science Foundation Coastal SEES: Toward Sustainable Urban Estuaries in the Anthropocene (OCE 1325136) and Ministry of Science and Technology (MOST 107‐2611‐M‐006‐004). We thank James Kirby, Fengyan Shi, and the two anonymous reviewers for their careful reading of our manuscript and their insightful comments. We thank Tracy Quirk for providing wave measurements in Bombay Hook, DE and Stow Creek, NJ. We thank Katie Pijanowski for compiling historical and modern bathymetric data for the estuary. Data supporting this study are posted to Zenodo (http://doi.org/10.5281/zenodo.1433055).
    Description: 2019-04-04
    Keywords: Estuarine hydrodynamics ; Wave energy ; Equilibrium wave ; Anthropogenic impact
    Repository Name: Woods Hole Open Access Server
    Type: Article
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