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  • 1
    Publication Date: 2011-06-04
    Description: The first Cenozoic ice sheets initiated in Antarctica from the Gamburtsev Subglacial Mountains and other highlands as a result of rapid global cooling approximately 34 million years ago. In the subsequent 20 million years, at a time of declining atmospheric carbon dioxide concentrations and an evolving Antarctic circumpolar current, sedimentary sequence interpretation and numerical modelling suggest that cyclical periods of ice-sheet expansion to the continental margin, followed by retreat to the subglacial highlands, occurred up to thirty times. These fluctuations were paced by orbital changes and were a major influence on global sea levels. Ice-sheet models show that the nature of such oscillations is critically dependent on the pattern and extent of Antarctic topographic lowlands. Here we show that the basal topography of the Aurora Subglacial Basin of East Antarctica, at present overlain by 2-4.5 km of ice, is characterized by a series of well-defined topographic channels within a mountain block landscape. The identification of this fjord landscape, based on new data from ice-penetrating radar, provides an improved understanding of the topography of the Aurora Subglacial Basin and its surroundings, and reveals a complex surface sculpted by a succession of ice-sheet configurations substantially different from today's. At different stages during its fluctuations, the edge of the East Antarctic Ice Sheet lay pinned along the margins of the Aurora Subglacial Basin, the upland boundaries of which are currently above sea level and the deepest parts of which are more than 1 km below sea level. Although the timing of the channel incision remains uncertain, our results suggest that the fjord landscape was carved by at least two iceflow regimes of different scales and directions, each of which would have over-deepened existing topographic depressions, reversing valley floor slopes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Young, Duncan A -- Wright, Andrew P -- Roberts, Jason L -- Warner, Roland C -- Young, Neal W -- Greenbaum, Jamin S -- Schroeder, Dustin M -- Holt, John W -- Sugden, David E -- Blankenship, Donald D -- van Ommen, Tas D -- Siegert, Martin J -- England -- Nature. 2011 Jun 2;474(7349):72-5. doi: 10.1038/nature10114.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Geophysics, Jackson School of Geosciences, University of Texas at Austin, Austin, Texas 78758, USA. duncan@utig.ig.utexas.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21637255" target="_blank"〉PubMed〈/a〉
    Keywords: Antarctic Regions ; *Climate Change ; Geography ; *Ice Cover/chemistry ; Oceans and Seas ; Oxygen Isotopes/analysis
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1986-12-05
    Description: A nonrepetitive complementary RNA probe specific for an intervening sequence of the rat pro-opiomelanocortin (POMC) gene primary transcript was used to analyze the hormonal regulation of POMC gene transcription in individual cell nuclei in the rat pituitary by in situ hybridization. This probe recognized only full-length POMC heterogeneous nuclear RNA, as verified by Northern blots of pituitary RNA. When pituitary sections were hybridized with this 3H-labeled POMC intron A probe, silver grains were predominantly localized over the nuclei of cells that expressed POMC in the anterior and intermediate lobes. Adrenalectomy increased both the average grain density over corticotroph nuclei and the number of cells in the anterior pituitary with significant numbers of silver grains over their nucleus. Dexamethasone administration to intact or adrenalectomized rats results in the rapid (within 30 minutes) disappearance of silver grains over the nuclei of corticotrophs in the anterior lobe, suggesting that POMC gene transcription had been inhibited. However, adrenalectomy or dexamethasone administration did not alter the silver grain density over nuclei of intermediate lobe melanotrophs. Thus, this in situ hybridization assay utilizing an intervening sequence-specific POMC probe can measure rapid physiological changes in POMC heterogeneous nuclear RNA in individual cell nuclei.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Fremeau, R T Jr -- Lundblad, J R -- Pritchett, D B -- Wilcox, J N -- Roberts, J L -- AM27484/AM/NIADDK NIH HHS/ -- NS07786/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1986 Dec 5;234(4781):1265-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3775385" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Nucleus/metabolism ; DNA/genetics ; Dexamethasone/pharmacology ; Gene Expression Regulation/drug effects ; Genes ; Male ; Nucleic Acid Hybridization ; Pituitary Gland, Anterior/metabolism ; Pro-Opiomelanocortin/*biosynthesis/genetics ; RNA, Messenger/genetics ; Rats ; Rats, Inbred Strains ; Transcription, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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