Publication Date:
2004-03-27
Description:
The apicomplexan Cryptosporidium parvum is an intestinal parasite that affects healthy humans and animals, and causes an unrelenting infection in immunocompromised individuals such as AIDS patients. We report the complete genome sequence of C. parvum, type II isolate. Genome analysis identifies extremely streamlined metabolic pathways and a reliance on the host for nutrients. In contrast to Plasmodium and Toxoplasma, the parasite lacks an apicoplast and its genome, and possesses a degenerate mitochondrion that has lost its genome. Several novel classes of cell-surface and secreted proteins with a potential role in host interactions and pathogenesis were also detected. Elucidation of the core metabolism, including enzymes with high similarities to bacterial and plant counterparts, opens new avenues for drug development.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Abrahamsen, Mitchell S -- Templeton, Thomas J -- Enomoto, Shinichiro -- Abrahante, Juan E -- Zhu, Guan -- Lancto, Cheryl A -- Deng, Mingqi -- Liu, Chang -- Widmer, Giovanni -- Tzipori, Saul -- Buck, Gregory A -- Xu, Ping -- Bankier, Alan T -- Dear, Paul H -- Konfortov, Bernard A -- Spriggs, Helen F -- Iyer, Lakshminarayan -- Anantharaman, Vivek -- Aravind, L -- Kapur, Vivek -- U01 AI 46397/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 2004 Apr 16;304(5669):441-5. Epub 2004 Mar 25.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Veterinary and Biomedical Science, College of Veterinary Medicine, University of Minnesota, St. Paul, MN 55108, USA. abe@umn.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15044751" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Antiprotozoal Agents/pharmacology
;
Carbohydrate Metabolism
;
Cryptosporidium parvum/*genetics/*metabolism/pathogenicity/physiology
;
DNA, Protozoan/genetics
;
Drug Resistance/genetics
;
Enzymes/genetics/*metabolism
;
Ethanol/metabolism
;
Genes, Protozoan
;
*Genome, Protozoan
;
Glycolysis
;
Introns
;
Mitochondria/genetics
;
Molecular Sequence Data
;
Multigene Family
;
Open Reading Frames
;
Organelles/genetics
;
Protozoan Proteins/chemistry/genetics/*metabolism
;
Purines/metabolism
;
Sequence Analysis, DNA
;
Transcription, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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