Publication Date:
2000-09-29
Description:
Mutations in the mitochondrial genome have been implicated in numerous human genetic disorders and offer important data for phylogenetic, forensic, and population genetic studies. Using a long-term series of Caenorhabditis elegans mutation accumulation lines, we performed a wide-scale screen for mutations in the mitochondrial genome that revealed a mutation rate that is two orders of magnitude higher than previous indirect estimates, a highly biased mutational spectrum, multiple mutations affecting coding function, as well as mutational hotspots at homopolymeric nucleotide stretches.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Denver, D R -- Morris, K -- Lynch, M -- Vassilieva, L L -- Thomas, W K -- R01-GM36827/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2000 Sep 29;289(5488):2342-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Biology and Biochemistry, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11009418" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Substitution
;
Animals
;
Base Composition
;
Base Pairing
;
Caenorhabditis elegans/*genetics
;
DNA, Helminth/chemistry/genetics
;
DNA, Mitochondrial/chemistry/*genetics
;
Evolution, Molecular
;
Frameshift Mutation
;
*Genome
;
Mitochondria/*genetics
;
Mutagenesis, Insertional
;
*Mutation
;
NADH Dehydrogenase/genetics
;
Phylogeny
;
Point Mutation
;
RNA, Transfer, Amino Acid-Specific/genetics
;
Repetitive Sequences, Nucleic Acid
;
Selection, Genetic
;
Sequence Deletion
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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