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  • 1
    Electronic Resource
    Electronic Resource
    Stable isotope methodology in a pharmacokinetic study of the interaction of theophylline and cimetidine (1982)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 9 (1982), S. 340-346 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Theophylline administered orally and (1, 3-15N,2-13C)theophylline administered intravenously in tracer quantities were used to investigate under steady-state conditions the interaction of theophylline with cimetidine in a patient with chronic obstructive pulmonary disease. Both compounds were quantified simultaneously by mass spectral-analysis after solvent extraction and high pressure liquid chromatographic purification of plasma samples. The assay is reliable and accurate to a plasma level of 50 ng mI-1 for the stable isotope tracer with a practical lower limit of detection of 10 ng mI-1.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200090807
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  • 2
    Electronic Resource
    Electronic Resource
    Electron-impact induced oxygen migration in the mass spectra of β-ketoalkylidenephosphoranes (1969)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 2 (1969), S. 1017-1021 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The mass spectra of six β-ketoalkylidenephosphoranes have been examined. The spectra all exhibit an electron-impact induced migration of oxygen to phosphorus reminiscent of their thermal decomposition.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210021010
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  • 3
    Electronic Resource
    Electronic Resource
    Mass spectral behavior of n-alkynesTaken, in part, from the MSc thesis of R. S. Mercer, University of Toronto, 1985. Dedicated to Professor Dr. H.-D. Beckey on the occasion of his 65th birthday. (1986)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 21 (1986), S. 717-722 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The 70 e V-electron impact mass spectra of the C7-C10 n-alkynes have been determined as well as the metastable ion spectra of the molecular ions and the [CS2]+ and [N2O]+ charge exchange mass spectra of the C7-C9 n-alkynes. The metastable ion mass spectra provide only a limited opportunity to distinguish between isomers; however, the 70-eV EI mass spectra of isomeric compounds permit a ready distinction between isomers. The [CS2]+ charge exchange mass spectra of isomeric compounds also show substantial differences. The [N2O]+ charge exchange mass spectra do not show the enhancement of β-fission fragments observed in field ionization experiments, despite representing ions of similar internal energy, and it is concluded that field dissociation is responsible for the β-fission fragments in the field ionization experiments.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210211017
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  • 4
    Electronic Resource
    Electronic Resource
    Charge inversion and neutralization-reionization mass spectra of some alkoxide ions (1987)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 22 (1987), S. 710-718 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The charge inversion mass spectra of C1 to C3 alkoxide ions have been obtained using He, N2 and O2 as collision gases. The three collision gases show similar efficiencies for collisional charge inversion and produce similar mass spectra, although fewer high-energy oxenium ions are formed when O2 and N2 are used as collision gases. Using two collision cells and an intermediate deflector electrode the alkoxide ions have been neutralized in the first collision cell and the fast neutrals ionized in the second cell. The neutralization-reionization mass spectra obtained are similar to the direct charge-inversion mass spectra indicating that mainly alkoxyl radicals are produced, although, depending on the neutralization collision gas and the alkoxide ion studied, other neutrals are formed in small yields. Deuterium isotopic labelling has been used to show that the main fragmentation reactions of the unstable oxenium ions formed involve 1,1-elimination of H2 or an alkane.
    Additional Material: 12 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210221104
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  • 5
    Electronic Resource
    Electronic Resource
    Two new sulphur-containing amino acids in man (1981)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 8 (1981), S. 99-104 
    Details
    ISSN: 1052-9306
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Two unusual sulphur-containing amino acids have been isolated from urine of a baby who died with major physical malformations and failure of growth and development. Sensitive mass spectrometric methods were used to identify the nanomole quantities of the compounds available as S-(2-carboxypropyl)-cysteine and S-(2-carboxypropyl)-cysteamine. Incubation of fibroblasts in either [14C]valine or [35S]cysteine resulted in radioactive labelling of the compounds, suggesting their origin from conjugation of methacrylic acid with cysteine and subsequent decarboxylation of the cysteine conjugate. Specific assay of methacrylyl-CoA hydratase is needed for final proof that this is a new inborn error of that enzyme, but these findings and parental consanguinity make this very likely. It seems possible that methacrylic acid or one of its derivatives may have caused the malformations present in the baby.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200080304
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  • 6
    Electronic Resource
    Electronic Resource
    Application of cyclodextrins to chiral analysis by 1H NMR spectroscopy (1988)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 26 (1988), S. 765-774 
    Details
    ISSN: 0749-1581
    Keywords: Inclusion comploxes ; Cyclodextrins ; Chiral antihistamines ; Chiral analgesics ; Chiral analysis ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The influence of inclusion complex formation between cyclodextrins (chiefly the β-polymer) and a variety of chiral antihistaminic and analgesic agents on the 1H NMR features of both guest and host partners is reported. In many cases equivalent protons of antipodes give resonances which differ in chemical shift after inclusion, and the potential value of the data to chiral analysis and to elucidation of the structures of the inclusion complexes is demonstrated.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1260260908
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  • 7
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    Pharmacological dissociation of modulatory effects of serotonin in Aplysia sensory neurons (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-12-20
    Description: In the mollusk Aplysia the neurotransmitter serotonin (5HT) has a fundamental modulatory role in several forms of learning and memory that involve an increase in the efficacy of synaptic transmission between tail sensory neurons (SNs) and motor neurons. The classical 5HT antagonist cyproheptadine (CYP) permits dissociation of three forms of serotonergic modulation in these SNs: (i) CYP reversibly blocks spike-broadening induced either by exogenous application of 5HT or by sensitizing stimulation of a tail nerve. (ii) CYP does not block 5HT-induced or tail input-induced increases in SN somatic excitability. (iii) Concomitant with its block of spike-broadening, CYP reversibly blocks 5HT-induced facilitation of synaptic transmission from SNs. These results suggest that endogenously released 5HT may act at different receptor subtypes that are coupled to different forms of neuromodulation in tail SNs of Aplysia.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mercer, A R -- Emptage, N J -- Carew, T J -- MH 141083/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1991 Dec 20;254(5039):1811-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Yale University, Department of Psychology, New Haven, CT 06520.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1662413" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Aplysia ; Cyproheptadine/*pharmacology ; Evoked Potentials/drug effects ; In Vitro Techniques ; Models, Neurological ; Motor Neurons/physiology ; Neurons, Afferent/drug effects/*physiology ; Serotonin/*pharmacology ; Synapses/drug effects/*physiology ; Synaptic Transmission/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 8
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    Regulatory role of parasites: impact on host population shifts with resource availability (1991)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1991-07-12
    Description: Effects of infections by the ciliate Lambornella clarki on larval populations of its mosquito host Aedes sierrensis were examined in laboratory and field studies. When host populations developed with sufficient food, mortality from parasites was additive and reduced the number of emerging mosquitoes. For food-limited populations, mortality was compensatory or depensatory; emerging adults were as or more abundant with higher average fitness than those from uninfected control populations. When nutrients were scarce, parasitic infections relaxed larval competition and increased per capita food by reducing host abundance. Food limitation altered larval feeding behavior, reducing horizontal transmission and subsequent mortality from parasitism.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Washburn, J O -- Mercer, D R -- Anderson, J R -- AI20245/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1991 Jul 12;253(5016):185-8.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Entomology, University of California, Berkeley 94720.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/1906637" target="_blank"〉PubMed〈/a〉
    Keywords: Aedes/*parasitology/physiology ; Animals ; Ciliophora/*physiology ; Ecology ; Population Dynamics ; Trees
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 9
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    Nanodiamonds in the Younger Dryas boundary sediment layer (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-01-03
    Description: We report abundant nanodiamonds in sediments dating to 12.9 +/- 0.1 thousand calendar years before the present at multiple locations across North America. Selected area electron diffraction patterns reveal two diamond allotropes in this boundary layer but not above or below that interval. Cubic diamonds form under high temperature-pressure regimes, and n-diamonds also require extraordinary conditions, well outside the range of Earth's typical surficial processes but common to cosmic impacts. N-diamond concentrations range from approximately 10 to 3700 parts per billion by weight, comparable to amounts found in known impact layers. These diamonds provide strong evidence for Earth's collision with a rare swarm of carbonaceous chondrites or comets at the onset of the Younger Dryas cool interval, producing multiple airbursts and possible surface impacts, with severe repercussions for plants, animals, and humans in North America.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kennett, D J -- Kennett, J P -- West, A -- Mercer, C -- Hee, S S Que -- Bement, L -- Bunch, T E -- Sellers, M -- Wolbach, W S -- New York, N.Y. -- Science. 2009 Jan 2;323(5910):94. doi: 10.1126/science.1162819.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Anthropology, University of Oregon, Eugene, OR 97403, USA. dkennett@uoregon.edu〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19119227" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Diamond ; Extinction, Biological ; *Geologic Sediments ; *Meteoroids ; Microscopy, Electron, Scanning Transmission ; Nanostructures ; North America ; Time
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis (2009)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2009-12-19
    Description: Acute exposure to ionizing radiation can cause lethal damage to the gastrointestinal (GI) tract, a condition called the GI syndrome. Whether the target cells affected by radiation to cause the GI syndrome are derived from the epithelium or endothelium and whether the target cells die by apoptosis or other mechanisms are controversial issues. Studying mouse models, we found that selective deletion of the proapoptotic genes Bak1 and Bax from the GI epithelium or from endothelial cells did not protect mice from developing the GI syndrome after sub-total-body gamma irradiation. In contrast, selective deletion of p53 from the GI epithelium, but not from endothelial cells, sensitized irradiated mice to the GI syndrome. Transgenic mice overexpressing p53 in all tissues were protected from the GI syndrome after irradiation. These results suggest that the GI syndrome is caused by the death of GI epithelial cells and that these epithelial cells die by a mechanism that is regulated by p53 but independent of apoptosis.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897160/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2897160/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kirsch, David G -- Santiago, Philip M -- di Tomaso, Emmanuelle -- Sullivan, Julie M -- Hou, Wu-Shiun -- Dayton, Talya -- Jeffords, Laura B -- Sodha, Pooja -- Mercer, Kim L -- Cohen, Rhianna -- Takeuchi, Osamu -- Korsmeyer, Stanley J -- Bronson, Roderick T -- Kim, Carla F -- Haigis, Kevin M -- Jain, Rakesh K -- Jacks, Tyler -- K08 CA 114176/CA/NCI NIH HHS/ -- K08 CA114176/CA/NCI NIH HHS/ -- K08 CA114176-05/CA/NCI NIH HHS/ -- P01 CA080124/CA/NCI NIH HHS/ -- P01 CA080124-01A1/CA/NCI NIH HHS/ -- P01 CA80124/CA/NCI NIH HHS/ -- P30 CA014051/CA/NCI NIH HHS/ -- P30 CA014051-38/CA/NCI NIH HHS/ -- P30 DK043351/DK/NIDDK NIH HHS/ -- P30-CA14051/CA/NCI NIH HHS/ -- RC1 AI078521/AI/NIAID NIH HHS/ -- RC1 AI078521-01/AI/NIAID NIH HHS/ -- RC1-AI078521/AI/NIAID NIH HHS/ -- U19-AI06775/AI/NIAID NIH HHS/ -- Howard Hughes Medical Institute/ -- New York, N.Y. -- Science. 2010 Jan 29;327(5965):593-6. doi: 10.1126/science.1166202. Epub 2009 Dec 17.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20019247" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Apoptosis ; Cell Death ; Epithelial Cells/cytology/physiology/radiation effects ; Gamma Rays/*adverse effects ; Gene Deletion ; Genes, p53 ; Intestinal Diseases/etiology/pathology/*physiopathology ; Intestinal Mucosa/pathology/physiopathology/*radiation effects ; Intestine, Small/pathology/physiopathology/*radiation effects ; Mesoderm/cytology ; Mice ; Mice, Transgenic ; Models, Biological ; Radiation Dosage ; Radiation Injuries/etiology/pathology/*physiopathology ; Tumor Suppressor Protein p53/*physiology ; bcl-2 Homologous Antagonist-Killer Protein/genetics/metabolism ; bcl-2-Associated X Protein/genetics/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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