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  • 1
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    Chromosome 2 sequence of the human malaria parasite Plasmodium falciparum (1998)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1998-11-06
    Description: Chromosome 2 of Plasmodium falciparum was sequenced; this sequence contains 947,103 base pairs and encodes 210 predicted genes. In comparison with the Saccharomyces cerevisiae genome, chromosome 2 has a lower gene density, introns are more frequent, and proteins are markedly enriched in nonglobular domains. A family of surface proteins, rifins, that may play a role in antigenic variation was identified. The complete sequencing of chromosome 2 has shown that sequencing of the A+T-rich P. falciparum genome is technically feasible.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gardner, M J -- Tettelin, H -- Carucci, D J -- Cummings, L M -- Aravind, L -- Koonin, E V -- Shallom, S -- Mason, T -- Yu, K -- Fujii, C -- Pederson, J -- Shen, K -- Jing, J -- Aston, C -- Lai, Z -- Schwartz, D C -- Pertea, M -- Salzberg, S -- Zhou, L -- Sutton, G G -- Clayton, R -- White, O -- Smith, H O -- Fraser, C M -- Adams, M D -- Venter, J C -- Hoffman, S L -- R01 AI40125-01/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1998 Nov 6;282(5391):1126-32.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Genomic Research, Rockville, MD 20850, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9804551" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antigens, Protozoan/chemistry/genetics ; Base Composition ; Chromosomes/*genetics ; Evolution, Molecular ; *Genes, Protozoan ; Genome, Protozoan ; Introns ; Membrane Proteins/chemistry/genetics ; Molecular Sequence Data ; Multigene Family ; Physical Chromosome Mapping ; Plasmodium falciparum/*genetics ; Protozoan Proteins/chemistry/*genetics ; RNA, Protozoan/genetics ; RNA, Transfer, Glu/genetics ; Repetitive Sequences, Nucleic Acid ; Reverse Transcriptase Polymerase Chain Reaction ; Sequence Alignment ; *Sequence Analysis, DNA
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Identification of vaccine candidates against serogroup B meningococcus by whole-genome sequencing (2000)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2000-03-10
    Description: Neisseria meningitidis is a major cause of bacterial septicemia and meningitis. Sequence variation of surface-exposed proteins and cross-reactivity of the serogroup B capsular polysaccharide with human tissues have hampered efforts to develop a successful vaccine. To overcome these obstacles, the entire genome sequence of a virulent serogroup B strain (MC58) was used to identify vaccine candidates. A total of 350 candidate antigens were expressed in Escherichia coli, purified, and used to immunize mice. The sera allowed the identification of proteins that are surface exposed, that are conserved in sequence across a range of strains, and that induce a bactericidal antibody response, a property known to correlate with vaccine efficacy in humans.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Pizza, M -- Scarlato, V -- Masignani, V -- Giuliani, M M -- Arico, B -- Comanducci, M -- Jennings, G T -- Baldi, L -- Bartolini, E -- Capecchi, B -- Galeotti, C L -- Luzzi, E -- Manetti, R -- Marchetti, E -- Mora, M -- Nuti, S -- Ratti, G -- Santini, L -- Savino, S -- Scarselli, M -- Storni, E -- Zuo, P -- Broeker, M -- Hundt, E -- Knapp, B -- Blair, E -- Mason, T -- Tettelin, H -- Hood, D W -- Jeffries, A C -- Saunders, N J -- Granoff, D M -- Venter, J C -- Moxon, E R -- Grandi, G -- Rappuoli, R -- New York, N.Y. -- Science. 2000 Mar 10;287(5459):1816-20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉IRIS, Chiron S.p.A., Via Fiorentina 1, 53100 Siena, Italy.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10710308" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Antibodies, Bacterial/biosynthesis/blood ; Antigens, Bacterial/chemistry/genetics/*immunology ; Antigens, Surface/chemistry/genetics/immunology ; Bacterial Capsules ; Bacterial Proteins/chemistry/genetics/*immunology ; *Bacterial Vaccines/genetics/immunology ; Conserved Sequence ; Escherichia coli/genetics ; *Genome, Bacterial ; Humans ; Immune Sera/immunology ; Mice ; Neisseria meningitidis/classification/*genetics/*immunology/pathogenicity ; Open Reading Frames ; Recombinant Fusion Proteins/chemistry/immunology/isolation & purification ; Recombination, Genetic ; Sequence Analysis, DNA ; Serotyping ; Vaccination ; Virulence
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Sex pheromones in snakes (1989)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1989-07-21
    Description: The majority of pheromones identified to date are insect pheromones, which are volatile in nature. Identification of nonvolatile pheromones have been relatively rare, especially in vertebrates. Male and female garter snakes use pheromones to mediate sexual behavior. The female sex attractiveness pheromone of the Canadian red-sided garter snake, Thamnophis sirtalis parietalis, consists of a novel series of nonvolatile saturated and monounsaturated long-chain methyl ketones, whereas the male sex recognition pheromone contains squalene. These compounds were isolated, identified, and partially synthesized, and field tests show them to be biologically active.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, R T -- Fales, H M -- Jones, T H -- Pannell, L K -- Chinn, J W -- Crews, D -- NICHHD 16687/HD/NICHD NIH HHS/ -- NIMH 00135/MH/NIMH NIH HHS/ -- NIMH 09310/MH/NIMH NIH HHS/ -- New York, N.Y. -- Science. 1989 Jul 21;245(4915):290-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Chemistry, National Heart, Lung, and Blood Institute, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2749261" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chromatography, Ion Exchange ; Female ; Gas Chromatography-Mass Spectrometry ; Magnetic Resonance Spectroscopy ; Male ; Pheromones/*isolation & purification ; Sex Attractants/analysis/chemical synthesis/*isolation & purification ; *Sexual Behavior, Animal ; Snakes/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    6-Hydroxydopamine and anticholinergic drugs (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-15
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, S T -- Fibiger, H C -- New York, N.Y. -- Science. 1978 Dec 15;202(4373):1215-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/725598" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Hydroxydopamines/*pharmacology ; Motor Activity/*drug effects ; Norepinephrine/pharmacology ; Parasympathomimetics/pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Kainic acid lesions of the striatum dissociate amphetamine and apomorphine stereotypy: similarities to Huntingdon's chorea (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: Kainic acid lesion of cell bodies in the dorsal striatum enhanced the stereotypy-producing effects of d-amphetamine without affecting the sterotypy produced by the direct receptor agonist apomorphine. This pattern of results parallels that found in patients suffering from Hungtington's chorea, thus strengthening the parallels between the kainic acid animal model and the human disease state initially suggested on biochemical gounds. The present results further suggest a dissociation of the mechanisms involved in the production of stereotypy by these two drugs, perhaps in terms of differential involvement of the striato-nigral negative feedback loop.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, S T -- Sanberg, P R -- Fibiger, H C -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):352-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26976" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apomorphine/*pharmacology ; Behavior/*drug effects ; Choline O-Acetyltransferase/metabolism ; Corpus Striatum/*drug effects/enzymology/pathology ; Dextroamphetamine/*pharmacology ; Disease Models, Animal ; Glutamate Decarboxylase/metabolism ; Humans ; Huntington Disease/*physiopathology ; *Kainic Acid/pharmacology ; Male ; Nucleus Accumbens/enzymology ; *Pyrrolidines/pharmacology ; Rats ; Stereotyped Behavior/*drug effects ; Tyrosine 3-Monooxygenase/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    On the specificity of kainic acid (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-06-22
    Description: The specificity of the neurotoxic agent, kainic acid, for destroying cell bodies while sparing terminals and fibers of passage was examined by infusing this agent into the axons of the dorsal noradrenergic bundle and measuring the degree of depletion of noradrenaline concentrations and the reduction in noradrenaline uptake in cortex and hippocampus. Extensive neuronal loss and gliosis were observed around the injection site. In addition, a significant and consistent 25 percent depletion of hippocampal-cortical noradrenaline was also obtained. The results suggest that although kainic acid has its greatest destructive action on neuronal perikarya, a significant amount of damage to axons of passage may also occur.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, S T -- Fibiger, H C -- New York, N.Y. -- Science. 1979 Jun 22;204(4399):1339-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451544" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic Fibers/*drug effects ; Animals ; Brain/metabolism ; Brain Stem/cytology/drug effects ; Cerebral Cortex/drug effects ; Hippocampus/drug effects ; Hydroxydopamines/pharmacology ; Kainic Acid/*pharmacology ; Locus Coeruleus/drug effects ; Male ; Neurons/*drug effects/ultrastructure ; Norepinephrine/metabolism ; Pyrrolidines/*pharmacology ; Rats
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Noradrenaline and seizures (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Mason, S T -- Corcoran, M E -- New York, N.Y. -- Science. 1979 Mar 23;203(4386):1265-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/424754" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Dopamine/physiology ; Drug Synergism ; Hydroxydopamines ; Norepinephrine/*physiology ; Pentylenetetrazole ; Rats ; Seizures/*chemically induced/physiopathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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