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  • Animals  (5)
  • American Association for the Advancement of Science (AAAS)  (5)
  • American Geophysical Union
  • 1
    Publication Date: 2001-11-27
    Description: With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Stoll, M -- Cowley, A W Jr -- Tonellato, P J -- Greene, A S -- Kaldunski, M L -- Roman, R J -- Dumas, P -- Schork, N J -- Wang, Z -- Jacob, H J -- 1P50-HL-54998/HL/NHLBI NIH HHS/ -- R01 HL064541/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 2001 Nov 23;294(5547):1723-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Physiology, Bioinformatics Research Center, and, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226-0509, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/11721057" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Pressure/drug effects/genetics ; *Cardiovascular Physiological Phenomena/drug effects ; Chromosome Mapping/*methods ; Chromosomes/genetics ; Crosses, Genetic ; Female ; Genomics/*methods ; Humans ; Kidney/physiology ; Lod Score ; Male ; Nitric Oxide Synthase/genetics ; Norepinephrine/pharmacology ; Phenotype ; Quantitative Trait, Heritable ; Rats ; Vasodilation/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1997-05-02
    Description: The neurofibromatosis type 1 (NF1) tumor suppressor protein is thought to restrict cell proliferation by functioning as a Ras-specific guanosine triphosphatase-activating protein. However, Drosophila homozygous for null mutations of an NF1 homolog showed no obvious signs of perturbed Ras1-mediated signaling. Loss of NF1 resulted in a reduction in size of larvae, pupae, and adults. This size defect was not modified by manipulating Ras1 signaling but was restored by expression of activated adenosine 3', 5'-monophosphate-dependent protein kinase (PKA). Thus, NF1 and PKA appear to interact in a pathway that controls the overall growth of Drosophila.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉The, I -- Hannigan, G E -- Cowley, G S -- Reginald, S -- Zhong, Y -- Gusella, J F -- Hariharan, I K -- Bernards, A -- NS22229/NS/NINDS NIH HHS/ -- NS34779/NS/NINDS NIH HHS/ -- NS36084/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1997 May 2;276(5313):791-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Massachusetts General Hospital Cancer Center and Harvard Medical School Building 149, 13th Street, Charlestown, MA 02129, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9115203" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Cell Count ; Cyclic AMP/metabolism ; Cyclic AMP-Dependent Protein Kinases/genetics/*metabolism ; Drosophila/cytology/*genetics/growth & development/metabolism ; *Drosophila Proteins ; GTP Phosphohydrolases/metabolism ; Genes, Insect ; Insect Proteins/chemistry/genetics/*metabolism ; Molecular Sequence Data ; Mutation ; *Nerve Tissue Proteins ; Neurofibromin 1 ; Phenotype ; Proteins/chemistry/genetics ; Recombinant Fusion Proteins/pharmacology ; Signal Transduction ; *ras GTPase-Activating Proteins ; ras Proteins/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    American Association for the Advancement of Science (AAAS)
    Publication Date: 1998-01-10
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cowley, A W Jr -- Schafer, J A -- Navar, L G -- New York, N.Y. -- Science. 1997 Oct 24;278(5338):557; author reply 560.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9381149" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Rights ; Animals ; Periodicals as Topic ; Physiology ; *Research ; Societies, Scientific ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2002-07-27
    Description: D-fenfluramine (d-FEN) was once widely prescribed and was among the most effective weight loss drugs, but was withdrawn from clinical use because of reports of cardiac complications in a subset of patients. Discerning the neurobiology underlying the anorexic action of d-FEN may facilitate the development of new drugs to prevent and treat obesity. Through a combination of functional neuroanatomy, feeding, and electrophysiology studies in rodents, we show that d-FEN-induced anorexia requires activation of central nervous system melanocortin pathways. These results provide a mechanistic explanation of d-FEN's anorexic actions and indicate that drugs targeting these downstream melanocortin pathways may prove to be effective and more selective anti-obesity treatments.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Heisler, Lora K -- Cowley, Michael A -- Tecott, Laurence H -- Fan, Wei -- Low, Malcolm J -- Smart, James L -- Rubinstein, Marcelo -- Tatro, Jeffrey B -- Marcus, Jacob N -- Holstege, Henne -- Lee, Charlotte E -- Cone, Roger D -- Elmquist, Joel K -- F31HG00201/HG/NHGRI NIH HHS/ -- P01DK056116/DK/NIDDK NIH HHS/ -- P01DK55819/DK/NIDDK NIH HHS/ -- R01MH061583/MH/NIMH NIH HHS/ -- R01MH44694/MH/NIMH NIH HHS/ -- R01MH61624/MH/NIMH NIH HHS/ -- R03TW01233/TW/FIC NIH HHS/ -- New York, N.Y. -- Science. 2002 Jul 26;297(5581):609-11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12142539" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Appetite Depressants/*pharmacology ; Arcuate Nucleus of Hypothalamus/*drug effects/metabolism ; Feeding Behavior/*drug effects ; Fenfluramine/*pharmacology ; Male ; Melanocyte-Stimulating Hormones/pharmacology ; Mice ; Mice, Obese ; Mice, Transgenic ; Neurons/drug effects/metabolism ; Paraventricular Hypothalamic Nucleus/drug effects/metabolism ; Patch-Clamp Techniques ; Pro-Opiomelanocortin/metabolism ; Rats ; Rats, Sprague-Dawley ; Receptor, Melanocortin, Type 3 ; Receptor, Melanocortin, Type 4 ; Receptor, Serotonin, 5-HT2C ; Receptors, Corticotropin/metabolism ; Receptors, Serotonin/metabolism ; Serotonin/metabolism ; Serotonin Agents/pharmacology ; alpha-MSH/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 2015-06-13
    Description: The distribution and interactions of aquatic organisms across space and time structure our marine, freshwater, and estuarine ecosystems. Over the past decade, technological advances in telemetry have transformed our ability to observe aquatic animal behavior and movement. These advances are now providing unprecedented ecological insights by connecting animal movements with measures of their physiology and environment. These developments are revolutionizing the scope and scale of questions that can be asked about the causes and consequences of movement and are redefining how we view and manage individuals, populations, and entire ecosystems. The next advance in aquatic telemetry will be the development of a global collaborative effort to facilitate infrastructure and data sharing and management over scales not previously possible.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hussey, Nigel E -- Kessel, Steven T -- Aarestrup, Kim -- Cooke, Steven J -- Cowley, Paul D -- Fisk, Aaron T -- Harcourt, Robert G -- Holland, Kim N -- Iverson, Sara J -- Kocik, John F -- Mills Flemming, Joanna E -- Whoriskey, Fred G -- New York, N.Y. -- Science. 2015 Jun 12;348(6240):1255642. doi: 10.1126/science.1255642. Epub 2015 Jun 11.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada. ; National Institute of Aquatic Resources, Technical University of Denmark, Vejlsoevej 39, DK-8600 Silkeborg, Denmark. ; Fish Ecology and Conservation Physiology Laboratory, Department of Biology and Institute of Environmental Science, Carleton University, 1125 Colonel By Drive, Ottawa, Ontario K1S 5B6, Canada. ; South African Institute for Aquatic Biodiversity, Private Bag 1015, Grahamstown 6140, South Africa. ; Department of Biological Sciences, Macquarie University, Sydney, New South Wales 2109, Australia. ; Hawaii Institute of Marine Biology, University of Hawaii at Manoa, Kane'ohe, HI 96744, USA. ; Ocean Tracking Network, Department of Biology, Dalhousie University, 1355 Oxford Road, Halifax, Nova Scotia B3H 4R2, Canada. sara.iverson@dal.ca. ; Northeast Fisheries Science Center, National Oceanic and Atmospheric Administration Fisheries, 17 Godfrey Drive, Orono, ME 04473, USA. ; Department of Mathematics and Statistics, Dalhousie University, 6316 Coburg Road, PO Box 15000, Halifax, Nova Scotia B3H 4R2, Canada. ; Ocean Tracking Network, Department of Biology, Dalhousie University, 1355 Oxford Road, Halifax, Nova Scotia B3H 4R2, Canada.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26068859" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Distribution ; Animals ; Aquatic Organisms/*physiology ; Endangered Species ; Environmental Monitoring/*methods ; Movement ; Telemetry/*methods/*trends
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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