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  • Polymer and Materials Science  (47)
  • Animals  (17)
  • 1985-1989  (40)
  • 1965-1969  (24)
  • 1
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    Reconstruction of an immune system (1988)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1988-09-23
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yancopoulos, G D -- Alt, F W -- New York, N.Y. -- Science. 1988 Sep 23;241(4873):1581-3.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Howard Hughes Medical Institute, Columbia University, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3262236" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; B-Lymphocytes/physiology ; *Chimera ; Immune System/cytology/*physiology/surgery ; Immune Tolerance ; Immunoglobulin Variable Region/genetics ; Immunologic Deficiency Syndromes/etiology/genetics ; Lymphoid Tissue/transplantation ; Mice ; Mice, Mutant Strains/*immunology ; *Models, Biological ; T-Lymphocytes/physiology ; Transplantation, Heterologous
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Multiple circadian oscillators regulate the timing of behavioral and endocrine rhythms in female golden hamsters (1985)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1985-05-17
    Description: A single daily "surge" in pituitary luteinizing hormone release was observed in ovariectomized-estrogen-treated hamsters expressing an intact circadian rhythm of locomotor activity. In contrast, two luteinizing hormone surges occurred within a single 24-hour period in hamsters whose activity rhythm had dissociated or "split" into two distinct components. These observations indicate that both behavioral and endocrine circadian rhythms are regulated by the same multioscillator system, which seems to be composed of at least two distinct circadian oscillators.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Swann, J M -- Turek, F W -- HD-07068/HD/NICHD NIH HHS/ -- HD-09885/HD/NICHD NIH HHS/ -- K04 HD-00249/HD/NICHD NIH HHS/ -- New York, N.Y. -- Science. 1985 May 17;228(4701):898-900.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/4001926" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Castration ; *Circadian Rhythm ; Cricetinae ; Estradiol/pharmacology ; Female ; Luteinizing Hormone/blood/*secretion ; Mesocricetus ; Motor Activity/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Development of the primary antibody repertoire (1987)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1987-11-20
    Description: The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Alt, F W -- Blackwell, T K -- Yancopoulos, G D -- AI-20047/AI/NIAID NIH HHS/ -- CA-40427/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 1987 Nov 20;238(4830):1079-87.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, College of Physicians and Surgeons of Columbia University, New York, NY 10032.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3317825" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Antibodies/*genetics ; *Antibody Diversity ; B-Lymphocytes/*physiology ; Gene Expression Regulation ; *Genes, Immunoglobulin ; Humans ; Immunoglobulin Variable Region/*genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Regulation of expression of the interleukin-2 receptor on hematopoietic cells by interleukin-3 (1986)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1986-07-25
    Description: Remarkable similarities in the intracellular and genetic events occur when lymphoid and hematopoietic cells are exposed to their specific growth factors. The interleukin-2 (IL-2) receptor, whose cell-surface expression is an absolute requirement for the growth and differentiation of lymphoid cells, was detected on various nonlymphoid hematopoietic cell types in this study. Cell lines consisting either of granulocyte-macrophage precursors or mast cells, which are dependent on interleukin-3 (IL-3) for their growth, expressed high levels of the IL-2 receptor on their surface. Analysis of the binding characteristics of these receptors with 125I-labeled recombinant IL-2 revealed that only receptors with low affinity for IL-2 were present on these cells. Addition of purified recombinant IL-3 to these cell lines led to an increase in IL-2 receptor gene expression within 1 hour in isolated nuclei. This IL-3--induced increase in the number of IL-2 receptors on the cell surface is maximal within 24 hours. Addition of 10,000 units of IL-2 to these cells had no apparent effect on their growth or differentiation. The presence of the receptor with only low affinity for IL-2 on hematopoietic cells and the regulation by IL-3 suggest that this receptor is involved in some important metabolic event in hematopoiesis.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Birchenall-Sparks, M C -- Farrar, W L -- Rennick, D -- Kilian, P L -- Ruscetti, F W -- New York, N.Y. -- Science. 1986 Jul 25;233(4762):455-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3088729" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Hematopoiesis/drug effects ; Hematopoietic Stem Cells/*drug effects/metabolism ; Humans ; Interleukin-2/pharmacology ; Interleukin-3 ; Lymphokines/*pharmacology ; Macrophages/drug effects/metabolism ; Mice ; Receptors, Immunologic/*biosynthesis/drug effects/genetics ; Receptors, Interleukin-2 ; T-Lymphocytes, Cytotoxic/drug effects/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Ammoniakdiffusion in Polymerfilmen (1989)
    Weinheim : Wiley-Blackwell
    Angewandte Makromolekulare Chemie 173 (1989), S. 69-84 
    Details
    ISSN: 0003-3146
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Description / Table of Contents: With the help of a novel test method, diffusion-coefficients of ammonia were determined in 22 transparent, filmforming polymers at room temperature. This method is based upon the UV-VIS-spectroscopically followable reversible reaction of ammonia with 4-nitro phenol to a Meisenheimer-complex.The dye-building reaction was studied and analyzed by a simple approximation of the diffusion equation. Diffusion coefficients obtained are in good agreement with the few available data in the literature.The dependence of the NH3-diffusion coefficients upon the polymer structure corresponds with the obtained diffusion coefficients, which are known for permanent gases.The described method allows the measurement of diffusion coefficients, which are distinguished up to three orders of magnitude, without any problem (ethylcellulose: 1,07 · 10-7 cm2 · s-1; poly(vinylalcohol): 0.9 · 10-10 cm2 · s-1).
    Notes: Mit Hilfe einer neuartigen Untersuchungsmethode wurden die Diffusionskoeffizienten von Ammoniak (NH3) in 22 transparenten filmbildenden Polymeren bei Raumtemperatur bestimmt. Die Methode beruht auf der UV-VIS-spektroskopisch verfolgbaren reversiblen Reaktion von Ammoniak mit 4-Nitrophenol zu einem 4-Nitrophenolat-Ammoniak-Meisenheimer-Komplex.Die Farbbildungsreaktion im Polymerfilm wurde untersucht und anhand einer einfachen Näherung der Diffusionsgleichung ausgewertet. Die erhaltenen Diffusionskoeffizienten stimmen sehr gut mit den wenigen verfügbaren Literaturwerten überein.Die Abhängigkeit der NH3-Diffusionskoeffizienten von der Polymerstruktur ist weitgehend der für permanente Gase bekannten analog.Die beschriebene Methode erlaubt problemlos, Diffusionskoeffizienten zu messen, die sich bis zu drei Größenordnungen unterscheiden (Ethylcellulose: 1,07 · 10-7 cm2 · s-1; Polyvinylalkohol: 0,9 · 10-10 cm2 · s-1).
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/apmc.1989.051730106
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  • 6
    Electronic Resource
    Electronic Resource
    Interaction of aminoacridines with deoxyribonucleic acid: Effects of ionic strength, denaturation, and structure (1965)
    New York : Wiley-Blackwell
    Biopolymers 3 (1965), S. 135-153 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The binding curves of various aminoacridines on calf thymus DNA have been determined by a spectrophotometric method. The dominant role of electrostatic forces in the interaction has been confirmed by the effect of ionic strength. Side chain and ring substituents in the aminoacridines do not inhibit binding, since this decreases in the order: acranil 〉 neomonacrin 〉 atebrin 〉 9-aminoacridine ∼ proflavine 〉 9-amino-1,2,3,4-tetrahydroacridine (THA). The last named shows the effect of diminishing the flat area of the rings in the aminoacridines. The shape of the binding curves of proflavine, 9-aminoacridine, and THA on thermally denatured DNA show that about 30-50% more binding sites are available to these cations on denatured DNA than on native DNA, but that the binding constants are the same. These observations are discussed in relation to the intercalation and other models for the interaction. It is concluded that exact and complete intercalation is not a necessary condition of strong binding and that other, less regular, models, in which the positive ring nitrogens of the acridines are close to the DNA phosphates and the acridine rings partially interact with the DNA base rings, are probably more consistent with the effect of denaturation of DNA on the binding curves which are characteristic of the interaction in solution.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.360030204
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  • 7
    Electronic Resource
    Electronic Resource
    Interaction of aminoacridines with deoxyribonucleic acid: Viscosity of the complexes (1966)
    New York : Wiley-Blackwell
    Biopolymers 4 (1966), S. 971-987 
    Details
    ISSN: 0006-3525
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The intrinsic, viscosities at zero shear rate of defined complexes of proflavine, 9-aminoacridine, and 9-amino-l,2,3,4-tetrahydroaeridine with calf thymus DNA have been determined at, various ionic strengths by means of rotating cylinder viscometers. By controlled adjustment, of the composition of the mixtures, the amount of bound acridine (r moles/g.-atom DNA phosphorus) was maintained constant at different dilutions. The intrinsic viscosities of the complexes increased with r up to r values (ca. 0.16-0.20) corresponding to the end of the process of strong binding of the acridinium cations. However, complex formation between the acridines and thermally denatured DNA caused either a marked decrease in viscosity (at the low ionic strengths of 0.0015 and 0.005) or no change at all (ionic strength 0.1). These results are discussed in the light of presently available hydrodynamic theories relating the intrinsic, viscosity of DNA to its molecular extension.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bip.1966.360040903
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  • 8
    Electronic Resource
    Electronic Resource
    Aromatic ionomer membranes. I. Physical and mechanical properties (1985)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 30 (1985), S. 2821-2836 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The physical properties of a new class of ionomers comprising a semirigid polyphenylene ether backbone were investigated. The material was studied principally in the form of films of ca. 150 μm micrometers in thickness. The study focused on material of 600 equivalent weight. Torsion pendulum results showed a significant increase in the glass transition temperature of the ionomer relative to that of its ester precursor but gave no evidence of ionic clustering. Stress-strain studies performed both in water and in 20% KOH solution at 80°C indicated that the mechanical properties of the material remain stable under these conditions. Differential scanning calorimetry was used to investigate both the high temperature behavior and the water uptake of the ionomer films. The behavior of this ionomer at high temperature and in an alkaline solution is of particular interest in view of the possible use of these films as separators in an alkaline electrolysis cell.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1985.070300709
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  • 9
    Electronic Resource
    Electronic Resource
    Polymers - The Origins and Growth of a Science, by Herbert Morawetz, Wiley-Interscience, New York, 1985, 306 pp. Price: $47.50 (1986)
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Letters Edition 24 (1986), S. 297-298 
    Details
    ISSN: 0887-6258
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1986.140240622
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  • 10
    Electronic Resource
    Electronic Resource
    Beitrag zur Vermeidung von chloridinduzierter transkristalliner Spannungsrißkorrosion bei höher legierten Chrom-Nickel-Stählen durch InhibitorenMitteilung aus dem Institut für Werkstoffkunde der TH Darmstadt. Auszug aus der Dissertation des erstgenannten Verfassers, Darmstadt D17, demnächst. (1985)
    Weinheim : Wiley-Blackwell
    Materialwissenschaft und Werkstofftechnik 16 (1985), S. 173-181 
    Details
    ISSN: 0933-5137
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Description / Table of Contents: Avoidance of Chloride Induced Transgranular Stress Corrosion Cracking of Stainless Steels by InhibitorsThe possibility to avoide chloride induced transgranular SCC of stainless steels with higher contents of chromium and nickel with the aid of organic inhibitors is shown. This method is successful as well in boiling aqueous solutions with high chloride concentration (open system) as in closed systems (higher temperature and pressure) with low chloride contents.
    Notes: Obwohl die Möglichkeit zur Hemmung von Korrosionsvorgängen durch Inhibitoren schon seit langem bekannt ist, wurden bisher kaum Versuche unternommen, die chloridinduzierte Spannungsrißkorrosion von höherlegierten Chrom-Nickel-Stählen durch Anwendung dieser Kenntnisse zu verhindern. In der vorliegenden Arbeit werden Ergebnisse aus Untersuchungen mit Tensiden und handelsüblichen Inhibitoren vorgestellt, die erkennen lassen, daß sowohl in höher chloridhaltigen siedenden wäßrigen Lösungen (offenes System) als auch in geschlossenen Systemen mit geringem Chloridgehalt bei höheren Temperaturen und Drücken eine deutliche Standzeitverlängerung erreichbar ist.
    Additional Material: 11 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mawe.19850160506
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