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  • 1
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    Cellular analysis of long-term habituation of the gill-withdrawal reflex of Aplysia californica (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-22
    Description: Long-term habituation training in Aplysia californica produces a profound depression in the efficacy of synaptic transmission between mechanoreceptor neurons and gill motor neurons. This depression persists for more than 3 weeks. Thus a critical synaptic site for plasticity underlying long-term habituation is the same as that for short-term habituation. For this simple form of learning, short- and long-term memory share a common locus and aspects of a common mechanism: synaptic depression.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Castellucci, V F -- Carew, T J -- Kandel, E R -- New York, N.Y. -- Science. 1978 Dec 22;202(4374):1306-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/214854" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Aplysia ; Gills/physiology ; Habituation, Psychophysiologic/*physiology ; Mechanoreceptors/physiology ; Memory/*physiology ; Memory, Short-Term/physiology ; Motor Neurons/physiology ; *Reflex, Monosynaptic ; Retention (Psychology)/physiology ; Synaptic Membranes/physiology ; Synaptic Transmission ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    The stomach signals satiety (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-14
    Description: Inflatable pyloric cuffs and stomach tubes were implanted in rats. With the cuff inflated and a valve to limit intragastric pressure to that accompanying normal satiety, they drank only as much when they had been deprived of food for 12 hours as without inflation of the cuff. However, they overdrank with the cuff inflated when they had been water deprived for 12 hours. When 10 ml of milk was withdrawn from the stomach with the cuff inflated, compensatory drinking occurred. Further, compensatory drinking also occurred when milk escaped from the stomach into the duodenum. Satiety signals thus arise from the stomach.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Deutsch, J A -- Young, W G -- Kalogeris, T J -- New York, N.Y. -- Science. 1978 Jul 14;201(4351):165-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663647" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Drinking Behavior/physiology ; Duodenum/physiology ; Food Deprivation ; Male ; Rats ; Satiation/*physiology ; Satiety Response/*physiology ; Stomach/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Subsynaptic plate perforations: changes with age and experience in the rat (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-08
    Description: The relative frequency of appearance of discontinuities in the postsynaptic thickening, or perforations in the subsynaptic plate, increased with age and experience. Rats reared from weaning in complex or social environments had a significantly higher proportion of occipital cortical synapses with perforations than did rats reared in isolation. In addition, the relative frequency of these perforations more than tripled between 10 and 60 days of age. Shifts in the frequency of perforations can occur independently of changes in the size of synpases. This result suggests a new potential mechanism of synaptic plasticity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Greenough, W T -- West, R W -- DeVoogd, T J -- New York, N.Y. -- Science. 1978 Dec 8;202(4372):1096-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/715459" target="_blank"〉PubMed〈/a〉
    Keywords: *Aging ; Animals ; Cerebral Cortex/ultrastructure ; Environment ; Male ; Occipital Lobe/*ultrastructure ; Rats ; Synapses/ultrastructure ; Synaptic Membranes/*ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    Flatworm control of mosquito larvae in rice fields (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-21
    Description: We describe some flatworms (some in the genus Mesostoma) that kill mosquito larvae and may account for the variability in the population densities of Culex tarsalis and Anopheles freeborni in rice fields. When mosquito larvae brush against these worms, the larvae immediately become paralyzed and die. When C. tarsalis larvae are placed inside floating cages that exclude flatworms (50-micromter mesh), there is a fourfold increase in the their survival. Rice fields that have abundant mosquito populations lack flatworms. Most such fields have only recently been turned over to rice production, suggesting that the flatworms have difficulty dispersing to new fields but, once established, are able to overwinter and control mosquitoes for the subsequent years of rice production.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Case, T J -- Washino, R K -- New York, N.Y. -- Science. 1979 Dec 21;206(4425):1412-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/41321" target="_blank"〉PubMed〈/a〉
    Keywords: Agriculture/*methods ; Animals ; Anopheles/physiology ; California ; Culex/physiology ; Culicidae/*physiology ; Insect Control/*methods ; Larva ; *Oryza ; Platyhelminths/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
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    Retention of an associative behavioral change in Hermissenda (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-29
    Description: The nudibranch mollusk Hermissenda crassicornis is normally attracted to a test light. Three days of training consisting of 50 trials per day of light paired with a rotational stimulus led to a significant increase, lasting for days, in the animal's response latency to enter a test light. The group that received light associated with rotation was significantly different from groups subjected to nonassociative control procedures. Modifications of well-known sensory networks may be related to a behavioral change that shares several operational features with associative learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crow, T J -- Alkon, D L -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694512" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Association Learning/*physiology ; Behavior, Animal/physiology ; Learning/*physiology ; Light ; Memory/*physiology ; Mollusca/*physiology ; Retention (Psychology)/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 6
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    6-Mercaptopurine treatment of pregnant mice: effects on second and third generations (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: The immunosuppressive drug 6-mercaptopurine is embryotoxic in mice. Of the surviving female offspring of mice treated with low doses of 6-mercaptopurine during pregnancy, despite normal body weight and general appearance, many were either sterile or, if they became pregnant, had smaller litters and more dead fetuses as compared to offspring of mothers that had not received the drug.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Reimers, T J -- Sluss, P M -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):65-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663638" target="_blank"〉PubMed〈/a〉
    Keywords: 6-Mercaptopurine/*pharmacology ; Animals ; Dose-Response Relationship, Drug ; Female ; Fetal Death/*chemically induced ; Fetus/drug effects ; Germ Cells/*drug effects ; Infertility, Female/*chemically induced ; Litter Size/drug effects ; Mice ; Ovary/cytology/drug effects/embryology ; Pregnancy ; Pregnancy, Animal/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    beta-Adrenergic regulation of adenosine 3',5'-monophosphate concentration in brain microvessels (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-20
    Description: Norepinephrine increases the concentration of adenosine 3',5'-monophosphate (cyclic AMP) in an incubated suspension of brain microvessels. This response can be matched by other drugs that stimulate the beta receptors, but the alpha-adrenergic agonist phenylephrine is without effect; beta-adrenergic blockade abolishes the response while alpha-adrenergic blockade produces no change. The data support the contention that cerebral capillary function is subject to adrenergic neural control.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Herbst, T J -- Raichle, M E -- Ferrendelli, J A -- New York, N.Y. -- Science. 1979 Apr 20;204(4390):330-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/34879" target="_blank"〉PubMed〈/a〉
    Keywords: Adrenergic beta-Agonists/*pharmacology ; Animals ; Capillaries/innervation/*metabolism ; *Cerebrovascular Circulation ; Cyclic AMP/*metabolism ; Dose-Response Relationship, Drug ; Male ; Norepinephrine/pharmacology ; Rats ; Sympatholytics/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-08-31
    Description: Depletion of dopamine in a circumscribed area of association cortex in rhesus monkeys produces an impairment in spatial delayed alternation performance nearly as severe as that caused by surgical ablation of the same area. This behavioral deficit can be pharmacologically reversed with dopamine agonists such as L-dopa and apomorphine. These data provide direct evidence that dopamine plays an important role in a specific cortical function.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brozoski, T J -- Brown, R M -- Rosvold, H E -- Goldman, P S -- New York, N.Y. -- Science. 1979 Aug 31;205(4409):929-32.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/112679" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Apomorphine/pharmacology ; Behavior, Animal/drug effects/physiology ; Cerebral Cortex/*physiology ; Cognition/drug effects/*physiology ; Dihydroxyphenylalanine/analogs & derivatives/pharmacology ; Dopamine/*physiology ; Dose-Response Relationship, Drug ; Haplorhini ; Levodopa/pharmacology ; Macaca mulatta ; Norepinephrine/physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Conditioned inhibition: selective response of single units (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-05-04
    Description: Single cell activity and local field potentials in parastriate cortex of cats and rabbits were studied during a Pavlovian discrimination procedure. Cell activity was selectively modified; conditioned changes occurred in response either to the reinforced stimulus or to the unreinforced one, but not to both. Cells exhibiting conditioned alteration in response to the unreinforced stimulus are thought to participate in specialized circuits mediating conditioned inhibition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉de Toledo-Morrell, L -- Hoeppner, T J -- Morrell, F -- New York, N.Y. -- Science. 1979 May 4;204(4392):528-30.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/432660" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cats ; Cerebral Cortex/physiology ; Conditioning (Psychology)/*physiology ; Neural Inhibition ; Rabbits ; Reinforcement (Psychology) ; Visual Cortex/*physiology ; Visual Perception/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Fertilization: a uterine glycosaminoglycan stimulates the conversion of sperm proacrosin to acrosin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-02-09
    Description: Acrosin is a proteinase required for mammalian fertilization, and in freshly ejaculated spermatozoa exists as an inactive zymogen, proacrosin. A factor prsent in uterine flushings of gilts stimulates the conversion of highly pruified boar proacrosin to acrosin. Characterization of this factor indicates that its active component is a glycosaminoglycan.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wincek, T J -- Parrish, R F -- Polakoski, K L -- New York, N.Y. -- Science. 1979 Feb 9;203(4380):553-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/32621" target="_blank"〉PubMed〈/a〉
    Keywords: Acrosin/*metabolism ; Animals ; Endopeptidases/*metabolism ; Enzyme Activation/drug effects ; Female ; *Fertilization ; Glycosaminoglycans/*pharmacology ; Hydrogen-Ion Concentration ; Male ; Protein Precursors/*metabolism ; Sperm Capacitation ; Spermatozoa/*enzymology ; Swine ; Uterus/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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