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  • 1
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    Associative behavioral modification in hermissenda: cellular correlates (1980)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1980-07-18
    Description: Three days of training consisting of trials of light paired with rotation produces a long-term modification of photopositive behavior in Hermissenda crassicornis. The behavioral modification depends on the temporal association of light and rotation. For animals that received light paired with rotation, significant increases in the spontaneous activity of type B photoreceptors were correlated with changes in photopositive behavior after training. A persistent tonic depolarization of type B photoreceptors can explain the cellular changes correlated with the long-term behavioral modification produced by the temporal association of light and rotation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crow, T J -- Alkon, D L -- New York, N.Y. -- Science. 1980 Jul 18;209(4454):412-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/17747814" target="_blank"〉PubMed〈/a〉
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Retention of an associative behavioral change in Hermissenda (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-29
    Description: The nudibranch mollusk Hermissenda crassicornis is normally attracted to a test light. Three days of training consisting of 50 trials per day of light paired with a rotational stimulus led to a significant increase, lasting for days, in the animal's response latency to enter a test light. The group that received light associated with rotation was significantly different from groups subjected to nonassociative control procedures. Modifications of well-known sensory networks may be related to a behavioral change that shares several operational features with associative learning.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crow, T J -- Alkon, D L -- New York, N.Y. -- Science. 1978 Sep 29;201(4362):1239-41.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694512" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Association Learning/*physiology ; Behavior, Animal/physiology ; Learning/*physiology ; Light ; Memory/*physiology ; Mollusca/*physiology ; Retention (Psychology)/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Neuropeptide Y distribution in the rat brain (1983)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1983-08-26
    Description: A massive neuronal system was detected by immunocytochemistry and radioimmunoassay with antibodies to neuropeptide Y, the recently isolated peptide of the pancreatic polypeptide family. Immunoreactive cell bodies and fibers were most prevalent in cortical, limbic, and hypothalamic regions. Neuropeptide Y was extracted in concentrations higher than those of any other peptide hitherto discovered in the mammalian brain. Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for immunostaining of pancreatic polypeptide-like immunoreactivity in the mammalian brain.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Allen, Y S -- Adrian, T E -- Allen, J M -- Tatemoto, K -- Crow, T J -- Bloom, S R -- Polak, J M -- New York, N.Y. -- Science. 1983 Aug 26;221(4613):877-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6136091" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Brain/*metabolism ; Nerve Tissue Proteins/immunology/*metabolism ; Neuropeptide Y ; Neurotransmitter Agents/metabolism ; Rats ; Tissue Distribution
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
    Electronic Resource
    Electronic Resource
    The biology of schizophrenia (1982)
    Springer
    Cellular and molecular life sciences 38 (1982), S. 1275-1282 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Conclusions Genes may be relevant not only to predisposition but also to the type of schizophrenic illness which occur, and determine whether symptoms of the type I or type II syndromes or a combination of the two are the major manifestations. Both syndromes, howerver, might be caused by a single agent, e.g.a. virus. Thus, amongst the population of patients at risk there is a group who experience a primary neurochemical disturbance (e.g. of dopaminergic transmission). This becomes manifest in positive symptoms (delusions, hallucinations and thought disorder) and might result from an affinity of the virus for a particular neurochemical structure (e.g. the D2 dopamine receptor or a molecule concerned in its regulation). Within this population however, is a sub-group that is predisposed to a more malignant and widespread disease. In these patients the virus gains further footholds in the nervous system, with the consequence that the disease acquires the characteristics of a chronic encephalitis. It is in these cases that there is evidence of structural change (although the site of the presumed cell loss has yet to be determined) and when present this change is associated with intellectual impairment and negative symptoms (the type II syndrome). Thus the disturbance underlying the type I syndrome is a neurochemical one which accounts for the reversibility of some schizophrenic symptoms and illnesses, and their response to neuroleptic drugs. It is compatible with Bleuler's view of schizophrenia as a functional psychosis which can be clearly distinguished from dementia. The change underlying the type II syndrome is progressive and irreversible and accounts for poor long-term outcome. To this form of illness Kraepelin's term dementia praecox can be applied with the term dementia retaining its contemporary connotation of organic psychosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01954914
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  • 5
    Electronic Resource
    Electronic Resource
    Impaired acquisition of a passive avoidance response after lesions induced in the locus coeruleus by 6-OH-dopamine (1976)
    [s.l.] : Nature Publishing Group
    Nature 259 (1976), S. 42-44 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] The prediction that bilateral lesions of the locus coeruleus would impair learning capacity1,2,13 has been tested in a runway8 and a two-choice discrimination learning test14. Since moderately extensive lesions of the locus coeruleus did not impair acquisition in this latter task it has been ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/259042b0
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  • 6
    Electronic Resource
    Electronic Resource
    Experimental Induction of β-Amyloid Plaques and Cerebral Angiopathy in Primates (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 695 (1993), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Notes: Moderate numbers of amyloid plaques with associated argyrophilic dystrophic neurites and cerebral amyloid angiopathy (CAA) but no neurofibrillary tangles (NFTs) were found in the brains of 3 middle-aged common marmosets (Callithrix jacchus) inoculated intracerebrally (i.e.) 6–7 years earlier with brain tissue from a patient with early onset Alzheimer's disease. The plaques and vascular amyloid stained positively with antibodies to β(A4)-protein. The brains of 3 age-matched control marmosets from the same colony did not show these neuropathological features, β-amyloid plaques and CAA (but no spongiform encephalopathy) were also found in the brain of a marmoset inoculated with brain tissue from a patient with priori disease with concomitant β-amyloid plaques and CAA. An occasional β-amyloid plaque was found in the brains of two marmosets inoculated with brain tissue from elderly patients. No β-amyloid plaques nor CAA were found in 6 other marmosets who were older than the inoculated marmosets, 10 further marmosets who were slightly younger but who had been inoculated several years previously with brain tissue which did not contain β-amyloid, and 10 younger marmosets who had been subjected to various neurosurgical procedures. These results suggest that β-amyloidosis is a transmissible process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1993.tb23057.x
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  • 7
    Electronic Resource
    Electronic Resource
    Reduced Cholecystokinin Levels in the Limbic Lobe in Schizophrenia (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 448 (1985), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1985.tb29943.x
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  • 8
    Electronic Resource
    Electronic Resource
    Mode of Enhancement of Self Stimulation in Rats by Methamphetamine (1969)
    [s.l.] : Nature Publishing Group
    Nature 224 (1969), S. 709-710 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Stein4 attempted to test these hypotheses of the central actions of the amphetamines using self stimulation in the rat. Small doses of amphetamines markedly enhanced low response rates. Because a-methyl tryptamine, a long acting "tryptamine receptor" stimulant, did not mimic this action, Stein ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/224709a0
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  • 9
    Electronic Resource
    Electronic Resource
    The effect of unilateral and bilateral lesions in the locus coeruleus on the levels of 3-methoxy-4-hydroxyphenylglycol (MHPG) in neocortex (1973)
    Springer
    Cellular and molecular life sciences 29 (1973), S. 52-53 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé Des lésions électrolytiques, soit unilatérales soit bilatérales, ont été pratiquées dans des cerveaux de rats, dans la région du locus coeruleus. Trois semaines après, la teneur en 3-méthoxy-4-hydroxyphénylglycol (MHPG) des deux cortices cérébraux a été analysée par chromatographie à gaz. Les lésions unilatérales ont réduit la teneur en MHPG du cortex ipsilatéral, et après les lésions bilatérales la réduction ent lieu dans les deux cortices.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01913247
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  • 10
    Electronic Resource
    Electronic Resource
    Brain failure after eighty years (1986)
    [s.l.] : Nature Publishing Group
    Nature 321 (1986), S. 481-481 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] IN 1907, Alois Alzheimer described the thickening and tortuosity of fibrils within the neuronal cytoplasm of almost every fourth cell of the cerebral cortex of a 51-year-old woman who had been suffering from dementia. At that time he can have had little conception of the growth of interest in the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/321481a0
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