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  • 1
    Publikationsdatum: 2011-11-04
    Beschreibung: The earliest anatomically modern humans in Europe are thought to have appeared around 43,000-42,000 calendar years before present (43-42 kyr cal BP), by association with Aurignacian sites and lithic assemblages assumed to have been made by modern humans rather than by Neanderthals. However, the actual physical evidence for modern humans is extremely rare, and direct dates reach no farther back than about 41-39 kyr cal BP, leaving a gap. Here we show, using stratigraphic, chronological and archaeological data, that a fragment of human maxilla from the Kent's Cavern site, UK, dates to the earlier period. The maxilla (KC4), which was excavated in 1927, was initially diagnosed as Upper Palaeolithic modern human. In 1989, it was directly radiocarbon dated by accelerator mass spectrometry to 36.4-34.7 kyr cal BP. Using a Bayesian analysis of new ultrafiltered bone collagen dates in an ordered stratigraphic sequence at the site, we show that this date is a considerable underestimate. Instead, KC4 dates to 44.2-41.5 kyr cal BP. This makes it older than any other equivalently dated modern human specimen and directly contemporary with the latest European Neanderthals, thus making its taxonomic attribution crucial. We also show that in 13 dental traits KC4 possesses modern human rather than Neanderthal characteristics; three other traits show Neanderthal affinities and a further seven are ambiguous. KC4 therefore represents the oldest known anatomically modern human fossil in northwestern Europe, fills a key gap between the earliest dated Aurignacian remains and the earliest human skeletal remains, and demonstrates the wide and rapid dispersal of early modern humans across Europe more than 40 kyr ago.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Higham, Tom -- Compton, Tim -- Stringer, Chris -- Jacobi, Roger -- Shapiro, Beth -- Trinkaus, Erik -- Chandler, Barry -- Groning, Flora -- Collins, Chris -- Hillson, Simon -- O'Higgins, Paul -- FitzGerald, Charles -- Fagan, Michael -- England -- Nature. 2011 Nov 2;479(7374):521-4. doi: 10.1038/nature10484.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Oxford Radiocarbon Accelerator Unit, Research Laboratory for Archaeology and the History of Art, University of Oxford, Oxford OX1 3QY, UK. thomas.higham@rlaha.ox.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22048314" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Animals ; Bayes Theorem ; Caves ; Dentition ; Emigration and Immigration/*history ; Fossils ; Great Britain ; History, Ancient ; Humans ; Maxilla/*anatomy & histology ; Neanderthals/anatomy & histology ; Radiometric Dating
    Print ISSN: 0028-0836
    Digitale ISSN: 1476-4687
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Publikationsdatum: 1993-10-01
    Beschreibung: In the assembly of a prespliceosome, U2 small nuclear ribonucleoprotein (snRNP) functions in pre-messenger RNA (mRNA) splicing together with splicing factors (SFs) 3a, SF3b, and several other proteins. The 17S but not the 12S form of U2 snRNP is active in splicing-complex formation. Here it is shown that the SF3a subunits correspond to three of the 17S U2 snRNP-specific polypeptides. SF3a interacts with U2 snRNP in the presence of SF3b to generate a structure similar to 17S U2 snRNP, which suggests a function for SF3a and SF3b in the incorporation of U2 snRNP into the spliceosome. Furthermore, the 60-kilodalton subunit of SF3a is related to the yeast splicing protein PRP9.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Brosi, R -- Groning, K -- Behrens, S E -- Luhrmann, R -- Kramer, A -- New York, N.Y. -- Science. 1993 Oct 1;262(5130):102-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Departement de Biologie Cellulaire, Sciences III, Universite de Geneve, Switzerland.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8211112" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Adenosine Triphosphate/metabolism ; Cross Reactions ; Electrophoresis, Polyacrylamide Gel ; Fungal Proteins/chemistry/immunology/*metabolism ; Humans ; Nuclear Proteins/chemistry/immunology/*metabolism ; *RNA Splicing ; RNA-Binding Proteins ; Ribonucleoprotein, U2 Small Nuclear/chemistry/*metabolism ; *Saccharomyces cerevisiae Proteins ; Spliceosomes/*metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Amsterdam : Elsevier
    FEBS Letters 353 (1994), S. 243-245 
    ISSN: 0014-5793
    Schlagwort(e): Biglycan ; Collagen-gel retraction ; Decorin ; Proteoglycan-100 ; TGF-β
    Quelle: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Thema: Biologie , Chemie und Pharmazie , Physik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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