Publication Date:
2012-07-24
Description:
Host protection from infection relies on the recognition of pathogens by innate pattern-recognition receptors such as Toll-like receptors (TLRs). Here, we show that the orphan receptor TLR13 in mice recognizes a conserved 23S ribosomal RNA (rRNA) sequence that is the binding site of macrolide, lincosamide, and streptogramin group (MLS) antibiotics (including erythromycin) in bacteria. Notably, 23S rRNA from clinical isolates of erythromycin-resistant Staphylococcus aureus and synthetic oligoribonucleotides carrying methylated adenosine or a guanosine mimicking a MLS resistance-causing modification failed to stimulate TLR13. Thus, our results reveal both a natural TLR13 ligand and specific mechanisms of antibiotic resistance as potent bacterial immune evasion strategy, avoiding recognition via TLR13.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Oldenburg, Marina -- Kruger, Anne -- Ferstl, Ruth -- Kaufmann, Andreas -- Nees, Gernot -- Sigmund, Anna -- Bathke, Barbara -- Lauterbach, Henning -- Suter, Mark -- Dreher, Stefan -- Koedel, Uwe -- Akira, Shizuo -- Kawai, Taro -- Buer, Jan -- Wagner, Hermann -- Bauer, Stefan -- Hochrein, Hubertus -- Kirschning, Carsten J -- New York, N.Y. -- Science. 2012 Aug 31;337(6098):1111-5. doi: 10.1126/science.1220363. Epub 2012 Jul 19.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute of Medical Microbiology, University of Duisburg-Essen, Essen, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22821982" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine/metabolism
;
Animals
;
Drug Resistance, Multiple, Bacterial/*immunology
;
Erythromycin/*pharmacology
;
Guanosine/metabolism
;
Lincosamides/pharmacology
;
Macrolides/pharmacology
;
Methylation
;
Mice
;
RNA, Ribosomal, 23S/*immunology
;
Staphylococcal Infections/*immunology
;
Staphylococcus aureus/drug effects/*immunology
;
Streptogramins/pharmacology
;
Toll-Like Receptors/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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