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  • 1
    Publication Date: 2002-12-17
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gostin, Lawrence O -- Sapsin, Jason W -- Teret, Stephen P -- Burris, Scott -- Mair, Julie Samia -- Hodge, James G Jr -- Vernick, Jon S -- New York, N.Y. -- Science. 2002 Dec 13;298(5601):2129; author reply 2129.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12481781" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioterrorism ; *Civil Rights ; Health Policy ; Humans ; Public Health/*legislation & jurisprudence ; *State Government ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 2
    Publication Date: 1988-12-09
    Description: Leber's hereditary optic neuropathy is a maternally inherited disease resulting in optic nerve degeneration and cardiac dysrhythmia. A mitochondrial DNA replacement mutation was identified that correlated with this disease in multiple families. This mutation converted a highly conserved arginine to a histidine at codon 340 in the NADH dehydrogenase subunit 4 gene and eliminated an Sfa NI site, thus providing a simple diagnostic test. This finding demonstrated that a nucleotide change in a mitochondrial DNA energy production gene can result in a neurological disease.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wallace, D C -- Singh, G -- Lott, M T -- Hodge, J A -- Schurr, T G -- Lezza, A M -- Elsas, L J 2nd -- Nikoskelainen, E K -- NS21328/NS/NINDS NIH HHS/ -- New York, N.Y. -- Science. 1988 Dec 9;242(4884):1427-30.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry, Emory University School of Medicine, Atlanta, GA 30322.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3201231" target="_blank"〉PubMed〈/a〉
    Keywords: African Continental Ancestry Group ; Animals ; Arginine ; Cytochrome Reductases/*genetics ; DNA, Mitochondrial/*genetics ; European Continental Ancestry Group ; Female ; *Genes ; Georgia ; Hereditary Sensory and Motor Neuropathy/*genetics ; Histidine ; Humans ; Macromolecular Substances ; Male ; *Mutation ; NADH Dehydrogenase/*genetics ; Optic Atrophies, Hereditary/*genetics ; Pedigree ; Reference Values
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
    Publication Date: 2010-09-11
    Description: The continued growth of human populations and of per capita consumption have resulted in unsustainable exploitation of Earth's biological diversity, exacerbated by climate change, ocean acidification, and other anthropogenic environmental impacts. We argue that effective conservation of biodiversity is essential for human survival and the maintenance of ecosystem processes. Despite some conservation successes (especially at local scales) and increasing public and government interest in living sustainably, biodiversity continues to decline. Moving beyond 2010, successful conservation approaches need to be reinforced and adequately financed. In addition, however, more radical changes are required that recognize biodiversity as a global public good, that integrate biodiversity conservation into policies and decision frameworks for resource production and consumption, and that focus on wider institutional and societal changes to enable more effective implementation of policy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rands, Michael R W -- Adams, William M -- Bennun, Leon -- Butchart, Stuart H M -- Clements, Andrew -- Coomes, David -- Entwistle, Abigail -- Hodge, Ian -- Kapos, Valerie -- Scharlemann, Jorn P W -- Sutherland, William J -- Vira, Bhaskar -- New York, N.Y. -- Science. 2010 Sep 10;329(5997):1298-303. doi: 10.1126/science.1189138.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Cambridge Conservation Initiative, Judge Business School, University of Cambridge, Cambridge CB2 1AG, UK. mr494@cam.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/20829476" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biodiversity ; *Conservation of Natural Resources/trends ; Decision Making ; Ecosystem ; Environment ; Humans ; International Cooperation ; Plants ; Population Dynamics ; Public Policy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
    Publication Date: 2004-05-01
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Middaugh, John P -- Hodge, James G -- Cartter, Matthew L -- New York, N.Y. -- Science. 2004 Apr 30;304(5671):681-4; author reply 681-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15118144" target="_blank"〉PubMed〈/a〉
    Keywords: *Bioethical Issues ; Disease Notification ; Humans ; Informed Consent ; *Population Surveillance ; Public Policy ; Registries ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
    Publication Date: 1996-12-13
    Description: The induction of cytokine gene transcription is mediated in part by the nuclear factor of activated T cells (NF-AT). Factors involved in the mechanisms of NF-AT-mediated transcription are not well understood. A nuclear factor that interacted with the Rel homology domain (RHD) of NF-ATp was identified with the use of a two-hybrid interaction trap. Designated NIP45 (NF-AT interacting protein), it has minimal similarity to any known genes. Transcripts encoding this factor were enriched in lymphoid tissues and testes. NIP45 synergized with NF-ATp and the proto-oncogene c-Maf to activate the interleukin-4 (IL-4) cytokine promoter; transient overexpression of NIP45 with NF-ATp and c-maf in B lymphoma cells induced measurable endogenous IL-4 protein production. The identification of NIP45 advances our understanding of gene activation of cytokines, critical mediators of the immune response.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Hodge, M R -- Chun, H J -- Rengarajan, J -- Alt, A -- Lieberson, R -- Glimcher, L H -- AI37833/AI/NIAID NIH HHS/ -- New York, N.Y. -- Science. 1996 Dec 13;274(5294):1903-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Cancer Biology, Harvard School of Public Health and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/8943202" target="_blank"〉PubMed〈/a〉
    Keywords: Amino Acid Sequence ; Animals ; Base Sequence ; Carrier Proteins/chemistry/genetics/*metabolism ; Cell Line ; Cell Nucleus/metabolism ; Cloning, Molecular ; DNA-Binding Proteins/*metabolism ; Genes, Reporter ; Humans ; Interleukin-4/*genetics ; *Intracellular Signaling Peptides and Proteins ; Male ; Molecular Sequence Data ; NFATC Transcription Factors ; Nuclear Proteins/chemistry/genetics/*metabolism ; Promoter Regions, Genetic ; Recombinant Fusion Proteins/metabolism ; Spleen/metabolism ; Testis/metabolism ; Thymus Gland/metabolism ; Transcription Factors/*metabolism ; *Transcriptional Activation ; Transfection ; Tumor Cells, Cultured
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
    Publication Date: 2013-08-31
    Description: Deep, narrowband H alpha Charge Coupled Device (CCD) surveys of HII regions were carried out in several dwarf irregular galaxies in and near the local group. Data are now complete for these galaxies: NGC 6822, GR 8, IC 10, IC 1613, Sextans A, Sextans B, and Sag Irr. Observations are complete for DDO 47, 53, 167, 168 and 187. Details of some of the results for the surveys completed so far are discussed. For NGC 6822, CCD survey at H alpha resulted in the detection of 145 HII regions in the local group irregular galaxy NGC 6822. Most of them are newly detected, faint surface-brightness objects. Positions, maps and dimensions are being published elsewhere. For GR 8, a deep narrowband H alpha imaging of the nearby dwarf irregular galaxy GR 8 revealed a total of 32 HII regions. Positions, H alpha luminosities, and sizes of these objects were determined. The H alpha luminosity function has the same shape as that for more luminous galaxies, except for size of sample effects. Most HII regions detected are at the very low luminosity end of the general luminosity function. For IC 10, a deep CCD narrowband H alpha imaging of the local group dwarf irregular galaxy IC 10 revealed a total of 144 HII regions. Positions, H alpha luminosities, and sizes of these objects were determined. The H alpha luminosity function has the same shape as that for more luminous galaxies.
    Keywords: ASTROPHYSICS
    Type: NASA, Ames Research Center, The Interstellar Medium in External Galaxies: Summaries of Contributed Papers; p 160-162
    Format: application/pdf
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  • 7
    Publication Date: 2013-08-31
    Description: The uncertain nature of the dwarf irregular galaxy UGC-A 86 (VIIZw009) makes it a very interesting object for studying star formation at the low end of the galaxy luminosity function. Saha and Hoessel (1991) find that this object is composed of two main parts, one of which appears more resolved than the other. The more resolved component has an excess of blue stars, suggesting that it is currently undergoing star formation. Thus, they argue that UGC-A 86 could be either a superposition of unrelated galaxies, two interacting galaxies, or a single galaxy. However, surface photometry performed by Richter et al. (1991) indicates that it is a single galaxy with an exponential luminosity profile. Richter et al. also find UGC-A 86 to be extremely dusty and to be associated with the infrared source IRAS 3550+6657. The uncertainty is compounded by the large ambiguity in the distance, though a heliocentric H1 velocity of 80 plus or minus 7 km s(sup -1) suggests that it is either a member of the Local Group or perhaps the IC 342 group. A distance of 1.5 Mpc and a reddening of E(B - V) = 0.65 is adopted. UGC-A 86 in H-alpha was observed in order to measure its current star formation rate. This is part of a larger project to study the star formation rates and histories of a complete sample of dwarf galaxies in the Local Group and other nearby groups. The H region luminosity function and size distribution for UGC-A 86 are presented and compared with previous observations of similar dwarf galaxies.
    Keywords: ASTROPHYSICS
    Type: NASA. Ames Research Center, The Evolution of Galaxies and Their Environment; p 90-91
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  • 8
    Publication Date: 2016-06-07
    Description: Morphological analyses of micrometeorite craters found on lunar rocks and laboratory simulation experiments are used to formulate a meteoritic interplanetary dust particle for optical scattering calculations that is roughly spherical and has a density of 2g cm/3. The model particle has chondritic elemental abundances and also contains a high content of finely dispersed carbon.
    Keywords: ASTROPHYSICS
    Type: NASA. Goddard Space Flight Center The Study of Comets, Part 2; p 962-982
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  • 9
    Publication Date: 2019-06-28
    Description: The ultraviolet energy distributions of the B stars in the LMC cluster NGC 2100 have been studied. The ultraviolet extinction law was studied for the LMC cluster. The T(eff)-luminosity diagrams were determined. The brightest stars in the cluster are evolved stars on the 'horizontal' supergiant branch. No P Cygni profiles indicating mass loss were recognized for these supergiants.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 292; 130-142
    Format: text
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  • 10
    Publication Date: 2019-06-28
    Description: The UV spectra between 1200 and 3000 A of stars in the young galactic cluster NGC 6530 and the surrounding association are studied. From the UBV colors and empirical as well as theoretical calibrations, the T(eff) and L for those stars which follow a sequence in the H-R diagram corresponding to the main sequence are determined. From a comparison with theoretical evolutionary tracks, the age of the cluster is estimated to be 5 + or - 2 x 10 to the 6th yr, with a very small scatter for the different stars. The UV extinction is determined for the stars from a comparison of theoretical model energy distributions for the stellar T(eff)s and the observed energy distributions. The stellar wind lines are studied, and strong stellar winds are found for bolometric magnetidues less than -8.
    Keywords: ASTROPHYSICS
    Type: Astrophysical Journal, Part 1 (ISSN 0004-637X); 287; 825-839
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