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  • AIRCRAFT DESIGN, TESTING AND PERFORMANCE  (2)
  • Carcinogenesis  (1)
  • left ventricular hypertrophy  (1)
  • 1
    Publication Date: 2011-08-18
    Description: To improve the prospects for success in the market place, the family approach is essential to the design of future supersonic airplanes. The evolution from a basic supersonic airplane to a family could follow historic patterns, with one exception: substantial changes in passenger carrying capacity will be difficult by the conventional fuselage "doughnut" approach so successfully used on the cylindrical fuselage of subsonic airplanes. The primary reasons for this difference include the requirement for highly integrated "area ruled" configurations, to give the desired high supersonic aerodynamic efficiency, and other physical limitations such as takeoff and landing rotation. A concept for a supersonic airplane family that could effectively solve the variable range and passenger capacity problem provides for modification of the fuselage cross section that makes it possible to build a family of three airplanes with four, five, and six abreast passenger seating. This is done by replacing or modifying portions of the fuselage. All airplanes share the same wing, engines, and major subsystems. Only small sections of the fuselage would be different, and aerodynamic efficiency need not be compromised.
    Keywords: AIRCRAFT DESIGN, TESTING AND PERFORMANCE
    Type: NASA. Langley Research Center Supersonic Cruise Res., 1979, Pt. 2; p 833-854
    Format: text
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  • 2
    Publication Date: 2016-06-07
    Description: Design changes that lead to improved aerodynamic and structural efficiency are presented. Practical design constraints and approaches for a blended wing-fuselage are discussed, as well as the integration of the configuration that leads to aerodynamic and structural efficiency. Highlighted are new approaches used to provide for structural efficiency, airline/passenger acceptance, passenger evacuation, and subsystem integration. Results of full-scale passenger cabin mock-up evaluations are presented showing the feasibility of the concept.
    Keywords: AIRCRAFT DESIGN, TESTING AND PERFORMANCE
    Type: NASA. Langley Res. Center Proc. of the SCAR Conf., Pt. 2,; 18 p
    Format: application/pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 39 (1990), S. S9 
    ISSN: 1432-1041
    Keywords: Cardiac microcirculation ; left ventricular hypertrophy ; myocardial ischemia ; stunned myocardium ; leukocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary I. Myocardial hypertrophy, for instance in patients with hypertensive heart disease, is characterized by a reduction of coronary vascular reserve, even in the presence of normal coronary arteries. In hypertensive animals, on the microcirculatory level functional changes can be observed before the onset of any structural rarefications. In 10 rats with renal hypertension and pressure-induced left ventricular hypertrophy (LVH), the microcirulation of the left ventricular myocardium was studied using in vivo fluorescence microscopy and morphometric analysis. Renal hypertension was provoked by clipping of the left renal artery. After 8 weeks, systolic blood pressure in LVH rats averaged 172 ± 8 mm Hg, compared to 91 ± 2 mmHg in 10 normotensive (NT) rats. In LVH rats, distances of plasma-perfused capillaries were significantly increased (NT = 17.7; LVH = 20 μm;p 〈 0.001). Volume density, surface density, and length density of capillaries in LVH rats were reduced by 20% compared to NT rats. Capillary red cell content as measured by the ratio of capillaries filled with red cells to those containing plasma alone (Q) in LVH animals exceeded that in NT rats (LVH: Q = 0.83 ± 0.04; NT Q = 0.77 ± 0.04;p 〈 0.025). During hypoxia (H, 5% 02) capillary red cell recruitment in LVH rats (Q: control c = 0.83; H = 0.95) was diminished by 33% as compared to NT rats (Q: c = 0.77; H = 0.95). Thus, in addition to the decreased capillary density, the reduction of capillary red cell recruitment may be responsible for chest pain in patients with LVH and normal coronary arteries. 2. In 11 rats, the microcirculation of the repeatedly ischemic (stunned) left ventricular myocardium (SM) was studied using in vivo fluorescence microscopy. Stunning was provoked by 6 subsequent 10 minute ligations of the left anterior descending coronary artery, each of them followed by a 20 min reperfusion period. In the SM showing hypokinetic wall motion mean capillary blood flow velocity was markedly reduced (control c =1312; SM = 694 μm/sec;p 〈 0.001): myocardial blood flow (hydrogen clearance) in the SM dropped by 55%. In SM, leukocytes often appeared in slow-flow capillaries plugging capillary branches: the percentage of capillaries and postcapillary venules with adherent leukocytes was markedly increased (c = 3%; SM = 68%). In close link to leukocyte adherence, a rise of microvascular permeability was documented by extravascular clouds of fluorescent dextran. The ratio of capillaries filled with red cells to those containing plasma alone was diminished in SM (c = 0.77; SM = 0.65;p 〈 0.001). In the SM there are microcirculatory disturbances which occur before the onset of detectable structural alterations of both the microvasculature and the myocyte.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Amsterdam : Elsevier
    Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 248 (1991), S. 341-356 
    ISSN: 0027-5107
    Keywords: Carcinogenesis ; Genotoxicity ; Sex hormones
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
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