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  • 05. General::05.04. Instrumentation and techniques of general interest::05.04.99. General or miscellaneous  (2)
  • antiphlogistic  (1)
  • man  (1)
  • pharmacokinetics
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 6 (1973), S. 261-267 
    ISSN: 1432-1041
    Keywords: Alclofenac ; antiphlogistic ; man ; pharmacokinetics ; dosage regimes ; plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A one compartment open model has been found to fit plasma concentration data previously obtained in man after single oral doses of alclofenac; the parameters of the model are: $${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}} $$ abs=1.3±0.7h, $${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}} $$ el=3.5±1.2h, Vd/F=17±6. The model has been used successfully to predict steady-state plasma levels of alclofenac after multiple oral doses. One treatment schedule (initial dose 500 mg, maintenance dose 250 mg five times a day) was administered to two volunteers for five days and the plasma levels of alclofenac determined daily. The latter were in good agreement with computer predictions based on the model. It is now possible, therefore, to select the most suitable dosage regimes for this drug.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2023-01-25
    Description: The measurements performed in Japan have shown that muon radiography is an “imaging technique” capable of providing information of the internal structure of volcanoes with a resolution and richness of details beyond the reach of conventional, non-imaging techniques. The measurements have been performed using electronic detectors or nuclear emulsions. The latter have shown excellent muon tracking capabilities and space resolution, but are lacking of the capability of electronic detectors to provide data in real time. In this paper, we examine the possibility of developing an electronic detector giving a resolution comparable to that of nuclear emulsions and with a larger area than used so far, in order to see deeper structures inside volcanoes in spite of the strong muon absorption in the rock. We specifically discuss the very challenging application of muon radiography to Mt. Vesuvius, driven by the strong social interest coming from the enormous potential danger which it represents. Applications to other volcanoes can be envisaged.
    Description: Published
    Description: 131-137
    Description: 3.6. Fisica del vulcanismo
    Description: JCR Journal
    Description: reserved
    Keywords: Volcanology ; muons ; cosmic rays ; radiography. ; 04. Solid Earth::04.02. Exploration geophysics::04.02.05. Downhole, radioactivity, remote sensing, and other methods ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques ; 05. General::05.04. Instrumentation and techniques of general interest::05.04.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
    Publication Date: 2023-01-25
    Description: The MU-RAY project has the challenging aim of performing muon radiography of the summit cone of Mt. Vesuvius. The muon telescopes developed for this purpose will be available for the radiography of other volcanoes, in particular Stromboli. The scientific goals, the strategy for their implementation and the baseline detector design are discussed in detail. A tentative time schedule for the project is drawn.
    Description: Published
    Description: 145–151
    Description: 3.6. Fisica del vulcanismo
    Description: JCR Journal
    Description: reserved
    Keywords: Muon ; radiography ; volcanoes ; 04. Solid Earth::04.02. Exploration geophysics::04.02.05. Downhole, radioactivity, remote sensing, and other methods ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques ; 05. General::05.04. Instrumentation and techniques of general interest::05.04.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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