Evaluation of alclofenac treatment regimes in man

Summary

A one compartment open model has been found to fit plasma concentration data previously obtained in man after single oral doses of alclofenac; the parameters of the model are:${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}}$ abs=1.3±0.7h,${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}}$ el=3.5±1.2h, Vd/F=17±6. The model has been used successfully to predict steady-state plasma levels of alclofenac after multiple oral doses. One treatment schedule (initial dose 500 mg, maintenance dose 250 mg five times a day) was administered to two volunteers for five days and the plasma levels of alclofenac determined daily. The latter were in good agreement with computer predictions based on the model. It is now possible, therefore, to select the most suitable dosage regimes for this drug.