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  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 6 (1973), S. 261-267 
    ISSN: 1432-1041
    Keywords: Alclofenac ; antiphlogistic ; man ; pharmacokinetics ; dosage regimes ; plasma levels
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A one compartment open model has been found to fit plasma concentration data previously obtained in man after single oral doses of alclofenac; the parameters of the model are: $${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}} $$ abs=1.3±0.7h, $${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}} $$ el=3.5±1.2h, Vd/F=17±6. The model has been used successfully to predict steady-state plasma levels of alclofenac after multiple oral doses. One treatment schedule (initial dose 500 mg, maintenance dose 250 mg five times a day) was administered to two volunteers for five days and the plasma levels of alclofenac determined daily. The latter were in good agreement with computer predictions based on the model. It is now possible, therefore, to select the most suitable dosage regimes for this drug.
    Type of Medium: Electronic Resource
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  • 2
    Publication Date: 2023-01-25
    Description: The MU-RAY detector has been designed to perform muon radiography of volcanoes. The possible use on the field introduces several constraints. First the electric power consumption must be reduced to the minimum, so that the detector can be solar-powered. Moreover it must be robust and transportable, for what concerns the front-end electronics and data acquisition. A 1m2 prototype has been constructed and is taking data at Mt.Vesuvius. The detector consists of modules of 32 scintillator bars with wavelength shifting fibers and silicon photomultiplier read-out. A dedicated front-end electronics has been developed, based on the SPIROC ASIC. An introduction to muon radiography principles, the MU-RAY detector description and results obtained in laboratory will be presented.
    Description: We acknowledge the support provided by the Istituto Nazionale di Fisica Nucleare(INFN). We wish to thank A.Brosfor the scintillator bars provided by FERMILAB-NICADD. We are grateful to Aldo Orlandi of the Laboratori Nazionali di Frascati of INFN for polishing and mirroring the fibers.
    Description: Published
    Description: 423-426
    Description: 1V. Storia e struttura dei sistemi vulcanici
    Description: JCR Journal
    Description: restricted
    Keywords: Muon radiography ; Muon detector ; SiPM ; Volcanoes ; Muography ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
    Publication Date: 2023-01-25
    Description: Muon Radiography allows to map the density of a volcanic cone. It is based on the measurement of the attenuation of the flux of muons present in the cosmic radiation on the ground. The MU-RAY project has developed an innovative detector designed for the muon radiography. The main features are the low electric power consumption, robustness and transportability, good spatial resolution and muon time of flight measurement. A 1 m2 detector prototype has been constructed. and collected data at Mt. Vesuvius for approximately 1 month in spring 2013. A second campaign of measurement has been performed at the Puy de Dˆome, France, in the last four months of 2013. In this article the principles of muon radiography, the MU-RAY detector and the first results from the collected data will be described.
    Description: Published
    Description: C02029
    Description: 1V. Storia e struttura dei sistemi vulcanici
    Description: JCR Journal
    Description: restricted
    Keywords: Particle tracking detectors ; Scintillators ; scintillation and light emission processes (solid, gas and liquid scintillators) ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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