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  • 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques  (3)
  • 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous  (2)
  • man  (1)
  • plasma levels
  • pharmacokinetics
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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    European journal of clinical pharmacology 6 (1973), S. 261-267 
    ISSN: 1432-1041
    Schlagwort(e): Alclofenac ; antiphlogistic ; man ; pharmacokinetics ; dosage regimes ; plasma levels
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A one compartment open model has been found to fit plasma concentration data previously obtained in man after single oral doses of alclofenac; the parameters of the model are: $${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}} $$ abs=1.3±0.7h, $${\text{t}}_{\tfrac{{\text{1}}}{{\text{2}}}} $$ el=3.5±1.2h, Vd/F=17±6. The model has been used successfully to predict steady-state plasma levels of alclofenac after multiple oral doses. One treatment schedule (initial dose 500 mg, maintenance dose 250 mg five times a day) was administered to two volunteers for five days and the plasma levels of alclofenac determined daily. The latter were in good agreement with computer predictions based on the model. It is now possible, therefore, to select the most suitable dosage regimes for this drug.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Publikationsdatum: 2023-01-25
    Beschreibung: The measurements performed in Japan have shown that muon radiography is an “imaging technique” capable of providing information of the internal structure of volcanoes with a resolution and richness of details beyond the reach of conventional, non-imaging techniques. The measurements have been performed using electronic detectors or nuclear emulsions. The latter have shown excellent muon tracking capabilities and space resolution, but are lacking of the capability of electronic detectors to provide data in real time. In this paper, we examine the possibility of developing an electronic detector giving a resolution comparable to that of nuclear emulsions and with a larger area than used so far, in order to see deeper structures inside volcanoes in spite of the strong muon absorption in the rock. We specifically discuss the very challenging application of muon radiography to Mt. Vesuvius, driven by the strong social interest coming from the enormous potential danger which it represents. Applications to other volcanoes can be envisaged.
    Beschreibung: Published
    Beschreibung: 131-137
    Beschreibung: 3.6. Fisica del vulcanismo
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): Volcanology ; muons ; cosmic rays ; radiography. ; 04. Solid Earth::04.02. Exploration geophysics::04.02.05. Downhole, radioactivity, remote sensing, and other methods ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques ; 05. General::05.04. Instrumentation and techniques of general interest::05.04.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Publikationsdatum: 2023-01-25
    Beschreibung: Cosmic-ray muon radiography is a technique for imaging the variation of density inside the top few 100m of a volcanic cone. With resolutions up to 10s of meters in optimal detection conditions, muon radiography can provide images of the top region of a volcano edifice with a resolution that is considerably better than that typically achieved with conventional methods. Such precise measurements are expected to provide us with information on anomalies in the rock density distribution, like those expected from dense lava conduits, low density magma supply paths or the compression with depth of the overlying soil. The MU-RAY project aims at the construction of muon telescopes and the development of new analysis tools for muon radiography. The telescopes are required to be able to work in harsh environment and to have low power consumption, good angular and time resolutions, large active area and modularity. The telescope consists of two X–Y planes of 2x2 square meters area made by plastic scintillator strips of triangular shape. Each strip is read by a fast WLS fiber coupled to a silicon photomultiplier. The readout electronics is based on the SPIROC chip.
    Beschreibung: Published
    Beschreibung: 120-123
    Beschreibung: 1.4. TTC - Sorveglianza sismologica delle aree vulcaniche attive
    Beschreibung: JCR Journal
    Beschreibung: restricted
    Schlagwort(e): Muon radiography ; Volcano structure ; Silicon photomultiplier ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Publikationsdatum: 2023-01-25
    Beschreibung: The MU-RAY project has the challenging aim of performing muon radiography of the summit cone of Mt. Vesuvius. The muon telescopes developed for this purpose will be available for the radiography of other volcanoes, in particular Stromboli. The scientific goals, the strategy for their implementation and the baseline detector design are discussed in detail. A tentative time schedule for the project is drawn.
    Beschreibung: Published
    Beschreibung: 145–151
    Beschreibung: 3.6. Fisica del vulcanismo
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): Muon ; radiography ; volcanoes ; 04. Solid Earth::04.02. Exploration geophysics::04.02.05. Downhole, radioactivity, remote sensing, and other methods ; 04. Solid Earth::04.08. Volcanology::04.08.07. Instruments and techniques ; 05. General::05.04. Instrumentation and techniques of general interest::05.04.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Publikationsdatum: 2023-01-25
    Beschreibung: The MU-RAY detector has been designed to perform muon radiography of volcanoes. The possible use on the field introduces several constraints. First the electric power consumption must be reduced to the minimum, so that the detector can be solar-powered. Moreover it must be robust and transportable, for what concerns the front-end electronics and data acquisition. A 1m2 prototype has been constructed and is taking data at Mt.Vesuvius. The detector consists of modules of 32 scintillator bars with wavelength shifting fibers and silicon photomultiplier read-out. A dedicated front-end electronics has been developed, based on the SPIROC ASIC. An introduction to muon radiography principles, the MU-RAY detector description and results obtained in laboratory will be presented.
    Beschreibung: We acknowledge the support provided by the Istituto Nazionale di Fisica Nucleare(INFN). We wish to thank A.Brosfor the scintillator bars provided by FERMILAB-NICADD. We are grateful to Aldo Orlandi of the Laboratori Nazionali di Frascati of INFN for polishing and mirroring the fibers.
    Beschreibung: Published
    Beschreibung: 423-426
    Beschreibung: 1V. Storia e struttura dei sistemi vulcanici
    Beschreibung: JCR Journal
    Beschreibung: restricted
    Schlagwort(e): Muon radiography ; Muon detector ; SiPM ; Volcanoes ; Muography ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Publikationsdatum: 2023-01-25
    Beschreibung: Muon Radiography allows to map the density of a volcanic cone. It is based on the measurement of the attenuation of the flux of muons present in the cosmic radiation on the ground. The MU-RAY project has developed an innovative detector designed for the muon radiography. The main features are the low electric power consumption, robustness and transportability, good spatial resolution and muon time of flight measurement. A 1 m2 detector prototype has been constructed. and collected data at Mt. Vesuvius for approximately 1 month in spring 2013. A second campaign of measurement has been performed at the Puy de Dˆome, France, in the last four months of 2013. In this article the principles of muon radiography, the MU-RAY detector and the first results from the collected data will be described.
    Beschreibung: Published
    Beschreibung: C02029
    Beschreibung: 1V. Storia e struttura dei sistemi vulcanici
    Beschreibung: JCR Journal
    Beschreibung: restricted
    Schlagwort(e): Particle tracking detectors ; Scintillators ; scintillation and light emission processes (solid, gas and liquid scintillators) ; 04. Solid Earth::04.08. Volcanology::04.08.99. General or miscellaneous
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
    Standort Signatur Erwartet Verfügbarkeit
    BibTip Andere fanden auch interessant ...
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