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  • 1
    Electronic Resource
    Electronic Resource
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 12 (1929), S. 989-990 
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Pharmaceutical formulations ; Triprolidine ; Pseudoephedrine ; Paracetamol ; Dextromethorphan
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A simple, rapid and specific HPLC method has been developed for the determination of triprolidine, pseudoephedrine, paracetamol and dextromethorphan, in combination, in different pharmaceutical dosage forms, using a reversed-phase C18 column, gradient elution, and UV detection at 254 and 280 nm. No preliminary extraction procedure is required for liquid formulations and a very simple extraction procedure is required for tablets and creams. The recovery of the drugs ranged from 96.0 to 98.7%. The assay results obtained for eight commercially available formulations were in agreement with the amounts declared. The linearity and precision of the method have been assessed.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Chromatographia 44 (1997), S. 619-622 
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Boldine in pharmaceuticals
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A method is proposed for extraction, separation, identification and quantitative measurement of boldine (I) in pharmaceuticals. The extraction of (I) from the matrix (syrups, tablets, extracts) was realized with aqueous ammonium chloride (0.02 M, pH=3.0 with perchloric acid) and the clean-up of the extract was performed by solid-phase extraction by means of cartridges containing a strong cation-exchange sorbent, from which (I) was eluted with aqueous ammonium chloride (1 M, pH=10.0 with ammonia). The final eluate was examined by HPLC. Chromatography was performed on a C-8 column with a gradient elution from 15:85 to 30:70 of acetonitrile-water containing 0.1 M sodium perchlorate (pH=3.0), in 20 min. A diode array detector was used at 302 nm for detection. The method gives recovery values greater than 98% and the reproducibility is within 6.0%.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Chromatographia 43 (1996), S. 76-78 
    ISSN: 1612-1112
    Keywords: Column liquid chromatography ; Rhodamine B in cosmetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary A method is proposed for the extraction, separation, identification and quantitative measurement of rhodamine B in cosmetics samples The colour is extracted with a solution of orthophosphoric acid in either water or DMF (depending on the type of cosmetic) adsorbed on a polyamide column, and then eluted with water and methanol. Further clean-up of the extract is performed by means of a Bond Elut C-18 cartridge, from which rhodamine B is eluted with methanol-water (8∶2). The final eluate is examined by HPLC. Chromatography is performed on a C-18 column with a gradient elution from 50∶50 to 70∶30 of acetonitrile-water, containing 0.1 M sodium perchlorate, in 15 min. A diodearray detector enables peak purity analysis. The method gives recovery values of approximately 90%, or better, and the reproducibility is within 4%.
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  • 5
    ISSN: 0899-0042
    Keywords: albendazole ; enantiomeric separation ; high performance liquid chromatography ; cellulose derived phase ; pharmacokinetic ; cysticercosis ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: We present a method for the enantioselective analysis of albendazole sulfoxide (ABZSO) in plasma for application in clinical pharmacokinetic studies. ABZSO enantiomers were separated on a 5-μm Chiralcel OB-H® column (4.6 × 150 mm) using hexane:ethanol (93:7, v/v) as the mobile phase and fluorescence detection. ABZSO was extracted with chloroform:isopropanol (8:2, v/v) from 500-μl aliquots of acidified plasma, with full drug recovery. The proposed method presented quantitation limits of 20 ng/ml for (-)ABZSO and 50 ng/ml for (+)ABZSO and was linear up to a concentration of 5,000 ng/ml of each enantiomer. Chirality 9:722-726, 1997. © 1997 Wiley-Liss, Inc.
    Additional Material: 3 Ill.
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  • 6
    ISSN: 0899-0042
    Keywords: optical resolution ; chiral HPLC ; chiral stationary phase ; 6-oxazolinylisoflavan ; circular dichroism ; antipicornavirus activity ; Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Racemic 6-oxazolinylisoflavan, a highly effective inhibitor of rhinovirus serotype 1B in vitro, was resolved by high-performance liquid chromatography on a chiral stationary phase in order to study the activity of the enantiomers against picornaviruses. The absolute configuration of the two isomers was determined by circular dichroism curves. The antipicornavirus activity of each isomer, separately collected, was evaluated in vitro against human rhinovirus serotype 1B, enterovirus 71, echovirus 6, coxsackievirus B4, and poliovirus type 2 by means of the plaque reduction assay. Both enantiomers were inhibitors of picornavirus replication with the degree of their activity depending on virus and isomer tested. © 1993 Wiley-Liss, Inc.
    Additional Material: 2 Ill.
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  • 7
    ISSN: 0173-0835
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: In cystic fibrosis (CF), the most common mutation, delta F508 (a three-base-pair deletion) accounts for ca. 70% of mutations in the worldwide population. The majority of other mutations (more than 350 reported so far to the Genetic Analysis Consortium) have been detected in single cases, thus rendering quite cumbersome a molecular diagnostic approach for the identification of CF chromosomes. As an alternative, linkage analysis based on intragenic polymorphism can be useful for prenatal diagnosis and CF-carrier detection, provided that the heterozygosity of the allelic forms is very high. For this purpose, DNA microsatellites, consisting of two to epta nucleotide repeat clusters, displaying a high degree of polymorphism, are being increasingly used as markers in linkage studies. Two main allelic forms, one hexameric (111 bp) and one heptameric (115 bp), of a tetranucleotide (GATT) repeat polymorphism, at the junction of intron IVS6a and exon 6b, have been amplified by PCR technology. These two alleles can be separated in a 10-20%T polyacrylamide gradient gel and detected by ethidium bromide staining. As an alternate procedure, these two fragments are efficiently separated by capillary zone electrophoresis in a viscous solution of 6%T linear polyacrylamide and detected by their intrinsic absorbance at 254 nm.
    Additional Material: 2 Ill.
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  • 8
    Publication Date: 2017-04-04
    Description: We describe the slope processes acting on Camaldoli Hill, the main volcanic feature of the Neapolitan area whose geological evolution and setting have been reconstructed. The backbone of the hill includes the remnants of two partially superposed tuff cones, lying between the Campanian Ignimbrite (CI) and the Neapolitan Yellow Tuff (NYT). This sequence is mantled by pyroclastic, anthropogenic and epiclastic deposits, with abrupt thickness and facies variations. The structural setting of the hill mainly results from several phases of reactivation of the CI caldera faults which were active until about 9.5 ka. Deformation younger than 15 ka is evidenced by landslide deposits, caused by slope instability from volcano-tectonism, and by a high-angle erosional unconformity, formed in response to a base-level lowering. A stratigraphic analysis of the reworked deposits at the foot of the slopes allowed us to define both depositional mechanisms and sedimentation rates. The results of combined volcanological, geomorphological and engineering-geological studies permitted us to constrain and quantify past geological processes and hypothesis about the future evolution of the hill. Present-day slope processes on Camaldoli Hill are largely controlled by the presence of weathered and reworked deposits, whose nature and thickness have been analysed and mapped in detail. Four main kinds of slope processes have been recognized: falls and toppling failures from NYT; small-scale slides in the weathered and pedogenized loose cover; mixed events, represented by slides evolving to hyperconcentrated flows, mud flows and debris flows; and areal and linear erosion. Consequently, a high number of mass movements not previously documented have been mapped. At the same time, an insight into the sedimentation rate due to the overall slope processes, covering a time-span of about 5 ka, was given. Some final considerations regarding landslide hazard are presented in the context of the most suitable remedial works.
    Description: Published
    Description: 132–157
    Description: 3.5. Geologia e storia dei sistemi vulcanici
    Description: 4.4. Scenari e mitigazione del rischio ambientale
    Description: JCR Journal
    Description: reserved
    Keywords: Slope processes ; Weathering ; Volcaniclastic rocks ; Hazard ; Risk ; 04. Solid Earth::04.04. Geology::04.04.03. Geomorphology ; 04. Solid Earth::04.04. Geology::04.04.07. Rock geochemistry ; 04. Solid Earth::04.04. Geology::04.04.08. Sediments: dating, processes, transport ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 9
    Publication Date: 2017-04-04
    Description: To develop a model of both the structure and evolution of the Campi Flegrei caldera (CFc) magmatic feeding system, geochronological, geochemical and Sr, Nd, Pb and B isotopic data of representative volcanic products of the past 15 ka have been combined with geophysical and melt inclusion literature data, structural setting and dynamics of the resurgent caldera. According to previous petrological data, the CFc magmatic feeding system consists of a deep reservoir, in which mantle-derived K-basaltic parental magmas differentiate to shoshonite, latite and trachyte, through combined crustal contamination and fractional crystallization processes, and shallowreservoirswhere the evolvedmagmas further differentiate andmingle/mix before eruptions. The Sr,Nd, Pb, and B isotope data allowrecognition of three distinctmagmatic components.One component is believedto be residualmagmafromtheNeapolitanYellowTuff (NYT) caldera forming eruption. The NYT component (87Sr/86Sr of 0.70750–53, 143Nd/144Nd ratio of ca. 0.51246, 206Pb/204Pb of ca. 19.04 and δ11B of ca. –7.9‰), has been the most prevalent component over the past 15 ka being mixed, in most cases, with the other two components. One of these other components is best recognized in the Minopoli 2 magma, first erupted 10 ka ago. Minopoli 2 magma is shoshonitic in composition and is the most enriched in radiogenic Sr (87Sr/86Sr of ca. 0.70860) and unradiogenic Nd and Pb (143Nd/144Nd ratio of ca. 0.51236, 206Pb/204Pb of ca. 18.90), and is characterised by δ11B value of ca. –7.32‰. The third component is trachytic in composition and has higher 206Pb/204Pb (ca. 19.08), lower 87Sr/86Sr (ca. 0.70726) and δ11B (−9.8‰) and higher 143Nd/144Nd (ca. 0.51250), with respect to the NYT component. This third component is best recognized in the Astroni 6 magma and did not appear until ca. 4 ka. The identified isotopically distinct magmatic components were erupted in different sectors of the CFc. During both I (b14.9–9.5 ka) and II (8.6–8.2 ka) epochs of volcanic activity,magmas similar to the NYT component, and those resulting from mixing between Minopoli 2 and NYT components were erupted from vents located mostly on the marginal faults of the NYT caldera. During the III epoch (4.8–3.8 ka) magmas either similar to NYT, or resulting from mixing between Astroni 6 and NYT components were erupted from vents located along faults bordering the La Starza resurgent block and, subordinately, the NYT caldera. Moreover, magmas resulting from mixing betweenMinopoli 2 and NYT components were erupted fromvents located along NE–SW regional faults activated during caldera resurgence. The inferred present structure of the feeding system is characterised by a deep reservoir, whose top is at about 8 kmdepth, that hosts shoshonitic–trachyticmagmas. Remnants of the NYT magma reside at shallower depth in different sectors of the crust underlying CFc, and were sometimes intercepted by volatile-rich magmas of deep provenance during the three epochs of CFc volcanic activity.
    Description: Published
    Description: 227-241
    Description: 2.3. TTC - Laboratori di chimica e fisica delle rocce
    Description: 3.5. Geologia e storia dei vulcani ed evoluzione dei magmi
    Description: JCR Journal
    Description: reserved
    Keywords: Campi Flegrei caldera ; Magmatic system ; Caldera structure ; Geochemistry ; Isotopes ; 04. Solid Earth::04.04. Geology::04.04.07. Rock geochemistry ; 04. Solid Earth::04.04. Geology::04.04.10. Stratigraphy ; 04. Solid Earth::04.08. Volcanology::04.08.05. Volcanic rocks
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 10
    Publication Date: 2017-04-04
    Description: The eruptive history of Mt. Somma–Vesuvius is characterised by large explosive events: Pomici di Base eruption (22,030±175 yr cal BP), Mercato (8890±90 yr cal BP), Avellino (3945±10 yr cal BP) and Pompeii (79 AD). Pre-eruptive conditions and sin-eruptive degassing processes of the Avellino eruption, the highest-magnitude Plinian event, have been investigated, using volatile contents (F, Cl, H2O) in melt inclusions and residual glass, and textural characteristics of pumice clasts of the 9 fallout layers sampled in detail in a representative sequence. The sequence displays an up-section sharp colour change from white to grey, corresponding to variations in both magma composition and textural characteristics. The pre-eruptive conditions have been constrained by systematic measurements of Cl content in both melt inclusions and matrix glass of pumice clasts. The pumice glass composition varies from Na-rich phonolite (white pumice) to Krich phonolite (grey pumice). The measured Cl values constantly cluster at 5200±400 ppm (buffer value), whatever the composition of the melt, suggesting that the entire magma body was saturated with subcritical fluids. This Cl saturation constrains the pre-eruptive pressures and maximum H2O contents at 200±10 MPa and 6.3±0.2 wt.% H2O for the white pumice melt and 195±15 MPa and 5.2±0.2 wt.% H2O for the grey pumice melt. The fluid phase, mainly composed of a H2O-rich vapour phase and brine, probably accumulated at the top of the reservoir and generated an overpressure able to trigger the onset of the eruption. Magma degassing was rather homogeneous for the white and grey eruptive units, mostly occurring through closed-system processes, leading to a typical Plinian eruptive style. A steady-state withdrawal of an H2O-saturated magma may explain the establishment of a sustained Plinian column. Variation from white to grey pumice is accompanied by decrease of mean vesicularity and increase of mean microcrystallinity and permeability related to significant vesicle coalescence. Despite this, the ascending magma column still evolves under closed-system degassing, without significant gas loss through conduit walls. The Avellino eruption shows numerous similarities with the 79 AD Pompeii eruption in pre-eruptive conditions, degassing processes and eruptive style which are discussed here.
    Description: IPGP contribution : N 3280.
    Description: Published
    Description: 257-268
    Description: 3.5. Geologia e storia dei vulcani ed evoluzione dei magmi
    Description: JCR Journal
    Description: restricted
    Keywords: Somma Vesuvius ; Avellino ; pre-eruptive conditions ; magma degassing ; Plinian eruption dynamics ; Pompeii ; 04. Solid Earth::04.04. Geology::04.04.07. Rock geochemistry
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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