Publication Date:
1990-07-13
Description:
Krev-1 is an anti-oncogene that was originally identified by its ability to induce morphologic reversion of ras-transformed cells that continue to express the ras gene. The Krev-1-encoded protein is structurally related to Ras proteins. The biological activities of a series of ras-Krev-1 chimeras were studied to test the hypothesis that Krev-1 may directly interfere with a ras function. The ras-specific and Krev-1-specific amino acids immediately surrounding residues 32 to 44, which are identical between the two proteins, determined whether the protein induced cellular transformation or suppressed ras transformation. Because this region in Ras proteins has been implicated in effector function, the results suggest that Krev-1 suppresses ras-induced transformation by interfering with interaction of Ras with its effector.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zhang, K -- Noda, M -- Vass, W C -- Papageorge, A G -- Lowy, D R -- New York, N.Y. -- Science. 1990 Jul 13;249(4965):162-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/2115210" target="_blank"〉PubMed〈/a〉
Keywords:
Amino Acid Sequence
;
Amino Acids/*physiology
;
Animals
;
Cell Transformation, Neoplastic/*genetics
;
Chimera
;
GTP-Binding Proteins/*genetics
;
*Gene Expression Regulation, Neoplastic
;
*Genes, ras
;
Harvey murine sarcoma virus/genetics
;
Molecular Sequence Data
;
Mutation
;
Restriction Mapping
;
*Suppression, Genetic
;
rap GTP-Binding Proteins
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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