Publication Date:
2004-05-25
Description:
We used molecular markers to study genetic relationships in a diverse collection of 85 domestic dog breeds. Differences among breeds accounted for approximately 30% of genetic variation. Microsatellite genotypes were used to correctly assign 99% of individual dogs to breeds. Phylogenetic analysis separated several breeds with ancient origins from the remaining breeds with modern European origins. We identified four genetic clusters, which predominantly contained breeds with similar geographic origin, morphology, or role in human activities. These results provide a genetic classification of dog breeds and will aid studies of the genetics of phenotypic breed differences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Parker, Heidi G -- Kim, Lisa V -- Sutter, Nathan B -- Carlson, Scott -- Lorentzen, Travis D -- Malek, Tiffany B -- Johnson, Gary S -- DeFrance, Hawkins B -- Ostrander, Elaine A -- Kruglyak, Leonid -- K05 CA90754/CA/NCI NIH HHS/ -- T32 HG00035/HG/NHGRI NIH HHS/ -- New York, N.Y. -- Science. 2004 May 21;304(5674):1160-4.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Human Biology, Fred Hutchinson Cancer Research Center, Post Office Box 19024, 1100 Fairview Avenue North, D4-100, Seattle, WA 98109-1024, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/15155949" target="_blank"〉PubMed〈/a〉
Keywords:
Algorithms
;
Animals
;
Bayes Theorem
;
Biological Evolution
;
*Breeding
;
Computational Biology
;
Dog Diseases/genetics
;
Dogs/classification/*genetics
;
*Genetic Variation
;
*Genome
;
Genotype
;
*Microsatellite Repeats
;
Phenotype
;
Phylogeny
;
Polymorphism, Single Nucleotide
;
Sequence Analysis, DNA
;
Software
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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