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  • Meteorology and Climatology  (3)
  • *Genetic Variation  (1)
  • 2010-2014  (4)
  • 1
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    Promoter architecture dictates cell-to-cell variability in gene expression (2014)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2014-12-20
    Beschreibung: Variability in gene expression among genetically identical cells has emerged as a central preoccupation in the study of gene regulation; however, a divide exists between the predictions of molecular models of prokaryotic transcriptional regulation and genome-wide experimental studies suggesting that this variability is indifferent to the underlying regulatory architecture. We constructed a set of promoters in Escherichia coli in which promoter strength, transcription factor binding strength, and transcription factor copy numbers are systematically varied, and used messenger RNA (mRNA) fluorescence in situ hybridization to observe how these changes affected variability in gene expression. Our parameter-free models predicted the observed variability; hence, the molecular details of transcription dictate variability in mRNA expression, and transcriptional noise is specifically tunable and thus represents an evolutionarily accessible phenotypic parameter.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388425/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉   〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4388425/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jones, Daniel L -- Brewster, Robert C -- Phillips, Rob -- 1 U54 CA143869/CA/NCI NIH HHS/ -- DP1 OD000217/OD/NIH HHS/ -- R01 GM085286/GM/NIGMS NIH HHS/ -- U54 CA143869/CA/NCI NIH HHS/ -- New York, N.Y. -- Science. 2014 Dec 19;346(6216):1533-6. doi: 10.1126/science.1255301. Epub 2014 Dec 18.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA. ; Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA. Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. ; Department of Applied Physics, California Institute of Technology, Pasadena, CA 91125, USA. Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. phillips@pboc.caltech.edu.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25525251" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Cells/*metabolism ; DNA-Directed RNA Polymerases/metabolism ; Escherichia coli/genetics ; Gene Dosage ; *Gene Expression Regulation ; *Genetic Variation ; In Situ Hybridization ; Kinetics ; Lac Repressors/genetics/metabolism ; Models, Genetic ; *Promoter Regions, Genetic ; Protein Binding ; RNA, Messenger/genetics ; Transcription, Genetic
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Observations During GRIP from HIRAD: Images of C-Band Brightness Temperatures and Ocean Surface Wind Speed and Rain Rate (2012)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: No abstract available
    Schlagwort(e): Meteorology and Climatology
    Materialart: M12-1498 , 92nd American Meteorological Society Annual Meeting; Jan 22, 2012 - Jan 26, 2012; New Orleans, LA; United States
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    Observations During GRIP from HIRAD: Ocean Surface Wind Speed and Rain Rate (2011)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-12
    Beschreibung: HIRAD (Hurricane Imaging Radiometer) flew on the WB-57 during NASA's GRIP (Genesis and Rapid Intensification Processes) campaign in August - September of 2010. HIRAD is a new C-band radiometer using a synthetic thinned array radiometer (STAR) technology to obtain cross-track resolution of approximately 3 degrees, out to approximately 60 degrees to each side of nadir. By obtaining measurements of emissions at 4, 5, 6, and 6.6 GHz, observations of ocean surface wind speed and rain rate can be inferred. This technique has been used for many years by precursor instruments, including the Stepped Frequency Microwave Radiometer (SFMR), which has been flying on the NOAA and USAF hurricane reconnaissance aircraft for several years. The advantage of HIRAD over SFMR is that HIRAD can observe a +/- 60-degree swath, rather than a single footprint at nadir angle. Results from the flights during the GRIP campaign will be shown, including images of brightness temperatures, wind speed, and rain rate. To the extent possible, comparisons will be made with observations from other instruments on the GRIP campaign, for which HIRAD observations are either directly comparable or are complementary. Potential impacts on operational ocean surface wind analyses and on numerical weather forecasts will also be discussed.
    Schlagwort(e): Meteorology and Climatology
    Materialart: M11-0223 , M11-1041 , 91st American Meterorological Society (AMS) Annual Meeting at the 15th Conference on Integrated Observing and Assimilation Systems for Atmosphere, Oceans, and Land Surface (IOAS-AOLS)/AMS)
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    Numerical Prediction of Dust (2013)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-12
    Beschreibung: Covers the whole breadth of mineral dust research, from a scientific perspective Presents interdisciplinary work including results from field campaigns, satellite observations, laboratory studies, computer modelling and theoretical studies Explores the role of dust as a player and recorder of environmental change This volume presents state-of-the-art research about mineral dust, including results from field campaigns, satellite observations, laboratory studies, computer modelling and theoretical studies. Dust research is a new, dynamic and fast-growing area of science and due to its multiple roles in the Earth system, dust has become a fascinating topic for many scientific disciplines. Aspects of dust research covered in this book reach from timescales of minutes (as with dust devils, cloud processes, and radiation) to millennia (as with loess formation and oceanic sediments), making dust both a player and recorder of environmental change. The book is structured in four main parts that explore characteristics of dust, the global dust cycle, impacts of dust on the Earth system, and dust as a climate indicator. The chapters in these parts provide a comprehensive, detailed overview of this highly interdisciplinary subject. The contributions presented here cover dust from source to sink and describe all the processes dust particles undergo while travelling through the atmosphere. Chapters explore how dust is lifted and transported, how it affects radiation, clouds, regional circulations, precipitation and chemical processes in the atmosphere, and how it deteriorates air quality. The book explores how dust is removed from the atmosphere by gravitational settling, turbulence or precipitation, how iron contained in dust fertilizes terrestrial and marine ecosystems, and about the role that dust plays in human health. We learn how dust is observed, simulated using computer models and forecast. The book also details the role of dust deposits for climate reconstructions. Scientific observations and results are presented, along with numerous illustrations. This work has an interdisciplinary appeal and will engage scholars in geology, geography, chemistry, meteorology and physics, amongst others with an interest in the Earth system and environmental change.
    Schlagwort(e): Meteorology and Climatology
    Materialart: GSFC-E-DAA-TN7780 , Mineral Dust - A Key Player in the Earth System
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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