Publication Date:
1987-11-27
Description:
The c-myc proto-oncogene is involved in chromosomal translocations that are specifically and consistently found in Burkitt lymphoma. Although these translocations are thought to lead to a deregulation of c-myc expression, the structural and functional basis of this phenomenon has not been identified. Mutations in a specific region spanning approximately 70 base pairs and located at the 3' border of the first exon of translocated c-myc alleles were consistently detected in Burkitt lymphoma cells carrying classic (8:14) as well as variant (8:22 and 2:8) translocations. These structural alterations were accompanied by an altered pattern of c-myc transcription, namely, the removal of a block to transcriptional elongation that has been mapped to the same region. Thus, specific c-myc mutations leading to the alleviation of this block to transcriptional elongation may represent a general mechanism causing c-myc activation in Burkitt lymphoma.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cesarman, E -- Dalla-Favera, R -- Bentley, D -- Groudine, M -- NCI 28151/CI/NCPDCID CDC HHS/ -- NCI 37165/CI/NCPDCID CDC HHS/ -- NCI 37195/CI/NCPDCID CDC HHS/ -- New York, N.Y. -- Science. 1987 Nov 27;238(4831):1272-5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Pathology, New York University School of Medicine, NY 10016.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/3685977" target="_blank"〉PubMed〈/a〉
Keywords:
Burkitt Lymphoma/*genetics
;
Cell Line
;
Chromosomes, Human, Pair 14
;
Chromosomes, Human, Pair 2
;
Chromosomes, Human, Pair 22
;
Chromosomes, Human, Pair 8
;
*Exons
;
Humans
;
*Mutation
;
*Proto-Oncogenes
;
*Transcription, Genetic
;
*Translocation, Genetic
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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