Publication Date:
2010-10-30
Description:
Transient populations of cis- and trans-acting small RNAs have recently emerged as key regulators of extensive epigenetic changes taking place during periconception, which encompasses gametogenesis, fertilization, and early zygotic development. These small RNAs are not only important to maintain genome integrity in the gametes and zygote, but they also actively contribute to assessing the compatibility of parental genomes at fertilization and to promoting long-term memory of the zygotic epigenetic landscape by affecting chromatin. Striking parallels exist in the biogenesis and modus operandi of these molecules among diverse taxa, unraveling universal themes of small-RNA-mediated epigenetic reprogramming during sexual reproduction.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bourc'his, Deborah -- Voinnet, Olivier -- New York, N.Y. -- Science. 2010 Oct 29;330(6004):617-22. doi: 10.1126/science.1194776.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institut Curie, CNRS UMR 3215, INSERM U934, 75248 Paris cedex 05, France. Deborah.Bourchis@curie.fr〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/21030645" target="_blank"〉PubMed〈/a〉
Keywords:
Angiosperms/genetics/metabolism/physiology
;
Animals
;
Ciliophora/genetics/metabolism/physiology
;
*Epigenesis, Genetic
;
*Fertilization
;
*Gametogenesis
;
Gametogenesis, Plant
;
Hybridization, Genetic
;
Mammals/genetics/metabolism/physiology
;
RNA, Plant/genetics/metabolism
;
RNA, Small Interfering/*genetics/metabolism
;
Zygote/*growth & development/metabolism
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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