Publication Date:
2013-09-07
Description:
Developmental gene expression is defined through cross-talk between the function of transcription factors and epigenetic status, including histone modification. Although several transcription factors play crucial roles in mammalian sex determination, how epigenetic regulation contributes to this process remains unknown. We observed male-to-female sex reversal in mice lacking the H3K9 demethylase Jmjd1a and found that Jmjd1a regulates expression of the mammalian Y chromosome sex-determining gene Sry. Jmjd1a directly and positively controls Sry expression by regulating H3K9me2 marks. These studies reveal a pivotal role of histone demethylation in mammalian sex determination.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kuroki, Shunsuke -- Matoba, Shogo -- Akiyoshi, Mika -- Matsumura, Yasuko -- Miyachi, Hitoshi -- Mise, Nathan -- Abe, Kuniya -- Ogura, Atsuo -- Wilhelm, Dagmar -- Koopman, Peter -- Nozaki, Masami -- Kanai, Yoshiakira -- Shinkai, Yoichi -- Tachibana, Makoto -- New York, N.Y. -- Science. 2013 Sep 6;341(6150):1106-9. doi: 10.1126/science.1239864.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Experimental Research Center for Infectious Diseases, Institute for Virus Research, Kyoto University, 53 Shogoin, Kawara-cho, Sakyo-ku, Kyoto, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24009392" target="_blank"〉PubMed〈/a〉
Keywords:
Animals
;
Epididymis/abnormalities
;
*Epigenesis, Genetic
;
Female
;
*Gene Expression Regulation, Developmental
;
Histones/*metabolism
;
Jumonji Domain-Containing Histone Demethylases/genetics/*metabolism
;
Male
;
Methylation
;
Mice
;
Mice, Mutant Strains
;
Mice, Transgenic
;
Ovary/abnormalities/enzymology
;
*Protein Processing, Post-Translational
;
Sex Determination Processes/*genetics
;
Testis/abnormalities/enzymology
;
Uterus/abnormalities
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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