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    Finding functional features in Saccharomyces genomes by phylogenetic footprinting (2003)
    American Association for the Advancement of Science (AAAS)
    Details
    Publikationsdatum: 2003-05-31
    Beschreibung: The sifting and winnowing of DNA sequence that occur during evolution cause nonfunctional sequences to diverge, leaving phylogenetic footprints of functional sequence elements in comparisons of genome sequences. We searched for such footprints among the genome sequences of six Saccharomyces species and identified potentially functional sequences. Comparison of these sequences allowed us to revise the catalog of yeast genes and identify sequence motifs that may be targets of transcriptional regulatory proteins. Some of these conserved sequence motifs reside upstream of genes with similar functional annotations or similar expression patterns or those bound by the same transcription factor and are thus good candidates for functional regulatory sequences.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cliften, Paul -- Sudarsanam, Priya -- Desikan, Ashwin -- Fulton, Lucinda -- Fulton, Bob -- Majors, John -- Waterston, Robert -- Cohen, Barak A -- Johnston, Mark -- R01 GM63803/GM/NIGMS NIH HHS/ -- New York, N.Y. -- Science. 2003 Jul 4;301(5629):71-6. Epub 2003 May 29.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Genetics, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/12775844" target="_blank"〉PubMed〈/a〉
    Schlagwort(e): Algorithms ; Base Sequence ; Binding Sites ; Computational Biology ; *Conserved Sequence ; *DNA, Intergenic ; Gene Expression Profiling ; Genes, Fungal ; *Genome, Fungal ; Molecular Sequence Data ; *Phylogeny ; *Regulatory Sequences, Nucleic Acid ; Saccharomyces/classification/*genetics/physiology ; Saccharomyces cerevisiae/genetics/physiology ; Sequence Alignment ; Sequence Analysis, DNA ; Transcription Factors/metabolism
    Print ISSN: 0036-8075
    Digitale ISSN: 1095-9203
    Thema: Biologie , Chemie und Pharmazie , Informatik , Medizin , Allgemeine Naturwissenschaft , Physik
    Publiziert von American Association for the Advancement of Science (AAAS)
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
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    Robotic Lunar Landers for Science and Exploration (2010)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-19
    Beschreibung: NASA Marshall Space Flight Center and The Johns Hopkins University Applied Physics Laboratory has been conducting mission studies and performing risk reduction activities for NASA s robotic lunar lander flight projects. In 2005, the Robotic Lunar Exploration Program Mission #2 (RLEP-2) was selected as a Exploration Systems Mission Directorate precursor robotic lunar lander mission to demonstrate precision landing and definitively determine if there was water ice at the lunar poles; however, this project was canceled. Since 2008, the team has been supporting NASA s Science Mission Directorate designing small lunar robotic landers for diverse science missions. The primary emphasis has been to establish anchor nodes of the International Lunar Network (ILN), a network of lunar science stations envisioned to be emplaced by multiple nations. This network would consist of multiple landers carrying instruments to address the geophysical characteristics and evolution of the moon. Additional mission studies have been conducted to support other objectives of the lunar science community and extensive risk reduction design and testing has been performed to advance the design of the lander system and reduce development risk for flight projects. This paper describes the current status of the robotic lunar mission studies that have been conducted by the MSFC/APL Robotic Lunar Lander Development team, including the ILN Anchor Nodes mission. In addition, the results to date of the lunar lander development risk reduction efforts including high pressure propulsion system testing, structure and mechanism development and testing, long cycle time battery testing and combined GN&C and avionics testing will be addressed. The most visible elements of the risk reduction program are two autonomous lander test articles: a compressed air system with limited flight durations and a second version using hydrogen peroxide propellant to achieve significantly longer flight times and the ability to more fully exercise flight sensors and algorithms. Robotic Lunar Lander design and development will have significant feed-forward to other missions to the Moon and, indeed, to other airless bodies such as Mercury, asteroids, and Europa, to which similar science and exploration objectives are applicable.
    Schlagwort(e): Cybernetics, Artificial Intelligence and Robotics
    Materialart: M10-0384 , 38th COSPAR Scientific Assembly; Jul 18, 2010 - Jul 25, 2010; Bremen, Germany; Germany
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
  • 3
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    Robotic Lunar Landers for Science and Exploration (2010)
    In:  CASI
    Details
    Publikationsdatum: 2019-07-13
    Beschreibung: NASA Marshall Space Flight Center (MSFC) and The Johns Hopkins University Applied Physics Laboratory (APL) have been conducting mission studies and performing risk reduction activities for NASA s robotic lunar lander flight projects. This paper describes some of the lunar lander concepts derived from these studies conducted by the MSFC/APL Robotic Lunar Lander Development Project team. In addition, the results to date of the lunar lander development risk reduction efforts including high pressure propulsion system testing, structure and mechanism development and testing, long cycle time battery testing and combined GN&C and avionics testing will be addressed. The most visible elements of the risk reduction program are two autonomous lander flight test vehicles: a compressed air system with limited flight durations and a second version using hydrogen peroxide propellant to achieve significantly longer flight times and the ability to more fully exercise flight sensors and algorithms.
    Schlagwort(e): Cybernetics, Artificial Intelligence and Robotics
    Materialart: M10-0385 , M10-0698 , 7th International Planetary Probe Workshop (IPPW-7); Jun 12, 2010 - Jun 18, 2010; Barcelona; Spain
    Format: application/pdf
    Standort Signatur Erwartet Verfügbarkeit
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    NASA TECHNICAL REPORTS
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