Publikationsdatum:
2012-06-16
Beschreibung:
Gut microbial communities represent one source of human genetic and metabolic diversity. To examine how gut microbiomes differ among human populations, here we characterize bacterial species in fecal samples from 531 individuals, plus the gene content of 110 of them. The cohort encompassed healthy children and adults from the Amazonas of Venezuela, rural Malawi and US metropolitan areas and included mono- and dizygotic twins. Shared features of the functional maturation of the gut microbiome were identified during the first three years of life in all three populations, including age-associated changes in the genes involved in vitamin biosynthesis and metabolism. Pronounced differences in bacterial assemblages and functional gene repertoires were noted between US residents and those in the other two countries. These distinctive features are evident in early infancy as well as adulthood. Our findings underscore the need to consider the microbiome when evaluating human development, nutritional needs, physiological variations and the impact of westernization.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376388/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376388/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Yatsunenko, Tanya -- Rey, Federico E -- Manary, Mark J -- Trehan, Indi -- Dominguez-Bello, Maria Gloria -- Contreras, Monica -- Magris, Magda -- Hidalgo, Glida -- Baldassano, Robert N -- Anokhin, Andrey P -- Heath, Andrew C -- Warner, Barbara -- Reeder, Jens -- Kuczynski, Justin -- Caporaso, J Gregory -- Lozupone, Catherine A -- Lauber, Christian -- Clemente, Jose Carlos -- Knights, Dan -- Knight, Rob -- Gordon, Jeffrey I -- DK078669/DK/NIDDK NIH HHS/ -- K01 DK090285/DK/NIDDK NIH HHS/ -- K05 AA017688/AA/NIAAA NIH HHS/ -- P01 DK078669/DK/NIDDK NIH HHS/ -- P01 DK078669-05/DK/NIDDK NIH HHS/ -- T32 HD049338-06/HD/NICHD NIH HHS/ -- T32-HD049338/HD/NICHD NIH HHS/ -- Howard Hughes Medical Institute/ -- England -- Nature. 2012 May 9;486(7402):222-7. doi: 10.1038/nature11053.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St Louis, Missouri 63108, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22699611" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Adolescent
;
Adult
;
Age Factors
;
Aged
;
Bacteria/*classification/*genetics
;
*Biodiversity
;
Child
;
Child, Preschool
;
Feces/microbiology
;
Female
;
Geography
;
Humans
;
Infant
;
Intestines/*microbiology
;
Malawi
;
Male
;
*Metagenome
;
Middle Aged
;
Phylogeny
;
RNA, Ribosomal, 16S/genetics
;
Twins, Dizygotic
;
Twins, Monozygotic
;
United States
;
Venezuela
;
Young Adult
Print ISSN:
0028-0836
Digitale ISSN:
1476-4687
Thema:
Biologie
,
Chemie und Pharmazie
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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