Publication Date:
2012-04-28
Description:
Immunoglobulin A (IgA) is essential to maintain the symbiotic balance between gut bacterial communities and the host immune system. Here we provide evidence that the inhibitory co-receptor programmed cell death-1 (PD-1) regulates the gut microbiota through appropriate selection of IgA plasma cell repertoires. PD-1 deficiency generates an excess number of T follicular helper (T(FH)) cells with altered phenotypes, which results in dysregulated selection of IgA precursor cells in the germinal center of Peyer's patches. Consequently, the IgAs produced in PD-1-deficient mice have reduced bacteria-binding capacity, which causes alterations of microbial communities in the gut. Thus, PD-1 plays a critical role in regulation of antibody diversification required for the maintenance of intact mucosal barrier.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kawamoto, Shimpei -- Tran, Thinh H -- Maruya, Mikako -- Suzuki, Keiichiro -- Doi, Yasuko -- Tsutsui, Yumi -- Kato, Lucia M -- Fagarasan, Sidonia -- New York, N.Y. -- Science. 2012 Apr 27;336(6080):485-9. doi: 10.1126/science.1217718.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Laboratory for Mucosal Immunity, Research Center for Allergy and Immunology, RIKEN Yokohama, Tsurumi, Yokohama, Japan.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/22539724" target="_blank"〉PubMed〈/a〉
Keywords:
Adoptive Transfer
;
Animals
;
B-Lymphocytes/*immunology
;
Bacteria/immunology
;
Bacterial Load
;
*Bacterial Physiological Phenomena
;
Feces/microbiology
;
Genes, Immunoglobulin Heavy Chain
;
Germinal Center/cytology/immunology
;
Immunoglobulin A/biosynthesis/*immunology
;
Intestinal Mucosa/*immunology
;
Intestine, Small/immunology/*microbiology
;
Lymphocyte Count
;
Mice
;
Peyer's Patches/cytology/immunology
;
Plasma Cells/immunology/physiology
;
Programmed Cell Death 1 Receptor/genetics/*physiology
;
Symbiosis
;
T-Lymphocytes, Helper-Inducer/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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