Publication Date:
2009-04-04
Description:
The basis of science is the hypothetico-deductive method and the recording of experiments in sufficient detail to enable reproducibility. We report the development of Robot Scientist "Adam," which advances the automation of both. Adam has autonomously generated functional genomics hypotheses about the yeast Saccharomyces cerevisiae and experimentally tested these hypotheses by using laboratory automation. We have confirmed Adam's conclusions through manual experiments. To describe Adam's research, we have developed an ontology and logical language. The resulting formalization involves over 10,000 different research units in a nested treelike structure, 10 levels deep, that relates the 6.6 million biomass measurements to their logical description. This formalization describes how a machine contributed to scientific knowledge.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉King, Ross D -- Rowland, Jem -- Oliver, Stephen G -- Young, Michael -- Aubrey, Wayne -- Byrne, Emma -- Liakata, Maria -- Markham, Magdalena -- Pir, Pinar -- Soldatova, Larisa N -- Sparkes, Andrew -- Whelan, Kenneth E -- Clare, Amanda -- Biotechnology and Biological Sciences Research Council/United Kingdom -- New York, N.Y. -- Science. 2009 Apr 3;324(5923):85-9. doi: 10.1126/science.1165620.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Computer Science, Aberystwyth University, SY23 3DB, UK. rdk@aber.ac.uk〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/19342587" target="_blank"〉PubMed〈/a〉
Keywords:
*Artificial Intelligence
;
*Automation
;
*Computational Biology
;
Computers
;
Enzymes/*genetics
;
*Genes, Fungal
;
Genomics
;
Programming Languages
;
Robotics
;
Saccharomyces cerevisiae/enzymology/*genetics/growth & development/metabolism
;
Software
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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