Publication Date:
2014-01-25
Description:
How the immune system adapts to malnutrition to sustain immunity at barrier surfaces, such as the intestine, remains unclear. Vitamin A deficiency is one of the most common micronutrient deficiencies and is associated with profound defects in adaptive immunity. Here, we found that type 3 innate lymphoid cells (ILC3s) are severely diminished in vitamin A-deficient settings, which results in compromised immunity to acute bacterial infection. However, vitamin A deprivation paradoxically resulted in dramatic expansion of interleukin-13 (IL-13)-producing ILC2s and resistance to nematode infection in mice, which revealed that ILCs are primary sensors of dietary stress. Further, these data indicate that, during malnutrition, a switch to innate type 2 immunity may represent a powerful adaptation of the immune system to promote host survival in the face of ongoing barrier challenges.〈br /〉〈br /〉〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313730/" target="_blank"〉〈img src="https://static.pubmed.gov/portal/portal3rc.fcgi/4089621/img/3977009" border="0"〉〈/a〉 〈a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4313730/" target="_blank"〉This paper as free author manuscript - peer-reviewed and accepted for publication〈/a〉〈br /〉〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spencer, S P -- Wilhelm, C -- Yang, Q -- Hall, J A -- Bouladoux, N -- Boyd, A -- Nutman, T B -- Urban, J F Jr -- Wang, J -- Ramalingam, T R -- Bhandoola, A -- Wynn, T A -- Belkaid, Y -- F30 DK094708/DK/NIDDK NIH HHS/ -- Z99 AI999999/Intramural NIH HHS/ -- New York, N.Y. -- Science. 2014 Jan 24;343(6169):432-7. doi: 10.1126/science.1247606.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Immunity at Barrier Sites Initiative, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Disease, NIH, Bethesda 20892, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/24458645" target="_blank"〉PubMed〈/a〉
Keywords:
*Adaptive Immunity
;
Animals
;
Citrobacter rodentium/immunology
;
Enterobacteriaceae Infections/immunology
;
Homeodomain Proteins/genetics
;
*Immunity, Innate
;
Interleukin-13/biosynthesis
;
Lymphocytes/*immunology
;
Mice
;
Mice, Inbred C57BL
;
Mice, Mutant Strains
;
Micronutrients/*deficiency
;
Vitamin A/*immunology
;
Vitamin A Deficiency/*immunology
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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