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Characterization of the chromatin structure in the upstream region of the chicken alpha-globin gene domain (1994)

Razin, S. V. ; Moura Gallo, C. V. ; Scherrer, K.

Springer

Molecular genetics and genomics 242 (1994), S. 649-652

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ISSN: 1617-4623

Keywords: α-Globin domain ; Hypersensitive sites ; Locus control region ; Chromatin structure

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Abstract The distribution of DNase I hypersensitive sites upstream of the chicken α-globin gene cluster was studied. A group of hypersensitive sites with a complex pattern of tissue specificity, including erythroid-specific elements, was found at a distance of 11.5–14.5 kb upstream of the π gene, the first gene in the cluster. The observations indicate that this area, located upstream of the block of AT-rich sequences and MAR sites (at −8 kb) and upstream of the site of permanent DNA attachment to the nuclear matrix (−3 kb), still belongs to the domain of the α-globin genes.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00283418

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