ISSN:
1573-904X
Keywords:
prostaglandin E1 α-cyclodextrin
;
1H nuclear magnetic resonance (NMR)
;
nuclear Overhauser effect (NOE) difference measurement
;
complex formation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Abstract Prostaglandin El is currently marketed as a freeze-dried injectable inclusion complex with α-cyclodextrin for the treatment of peripheral arterial diseases. α-Cyclodextrin is used as a stabilizing agent and to improve the dissolution characteristics of prostaglandin El. Upon dilution with the infusion medium, the inclusion complex dissociates almost completely as shown by NMR chemical shift measurements of the complexed and uncomplexed prostaglandin E1 Nuclear Overhauser effect (NOE) measurements of the interacting atoms of α-cyclodextrin and prostaglandin El provide insight into the structure of the complex.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1023/A:1015865002470
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