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1H-Nuclear Magnetic Resonance (NMR) Studies on the Inclusion Complex of Prostaglandin El (PGE1 with α-Cyclodextrin

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Abstract

Prostaglandin El is currently marketed as a freeze-dried injectable inclusion complex with α-cyclodextrin for the treatment of peripheral arterial diseases. α-Cyclodextrin is used as a stabilizing agent and to improve the dissolution characteristics of prostaglandin El. Upon dilution with the infusion medium, the inclusion complex dissociates almost completely as shown by NMR chemical shift measurements of the complexed and uncomplexed prostaglandin E1 Nuclear Overhauser effect (NOE) measurements of the interacting atoms of α-cyclodextrin and prostaglandin El provide insight into the structure of the complex.

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REFERENCES

  1. J. Szeijtli. Cyclodextrin Technology, Kluwer Academic, Dordrecht, 1988.

    Google Scholar 

  2. J. Szeijtli. Cyclodextrins in drug formulations, I and II. Pharm. Technol. Int. 3:Feb. and March (1991).

  3. G. E. Hardee, M. Otagiri, and J. H. Perrin. Microcalorimetric investigations of pharmaceutical complexes. I. Drugs and β-cyclodextrin. Acta Pharm. Suec. 15:188–199 (1978).

    Google Scholar 

  4. S. Takagi and M. Maeda. Calorimetric determination of enthalpies, Gibbs energies, and entropies of inclusion of some alcohols into α-and β-cyclodextrins in aqueous solutions. J. Inclus. Phen. 2:775–780 (1984).

    Google Scholar 

  5. S. G. Frank and M. J. Cho. Phase solubility analysis and PMR study of complexing behaviour of dinoprostone with β-cyclodextrin in water. J. Pharm. Sci. 67:1665–1668 (1978).

    Google Scholar 

  6. R. I. Gelb, L. M. Schwartz, B. Cardelino, H. S. Fuhrmann, R. F. Johnson, and D. A. Laufer. Binding mechanisms in cyclohexaamylose complexes. J. Am. Chem. Soc. 103:1750–1757 (1981).

    Google Scholar 

  7. E. A. Lewis and L. D. Hansen. Thermodynamics of binding of guest molecules to α-and β-cyclodextrins. J. Chem. Soc. Perkin Trans. II 2081–2085 (1973).

    Google Scholar 

  8. K. Uekama and F. Hirayama. Inclusion complexation of prostaglandin F2a with α-and β-cyclodextrins in aqueous solution. Chem. Pharm. Bull. 26:1195–1200 (1978).

    Google Scholar 

  9. Ger. Offen DE 2 128 674 C2.

  10. W. Saenger. Cyclodextrin-Einschluβverbindungen in Forschung und Industrie. Angew. Chem. 92:343–361 (1980).

    Google Scholar 

  11. J. H. Noggle and R. E. Schirmer. The Nuclear Overhauser Effect, Academic Press, New York, 1971.

    Google Scholar 

  12. K. Wüthrich. NMR of Proteins and Nucleic Acids, John Wiley and Sons, New York, 1986.

    Google Scholar 

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Steffan, B., Fischer, W., Cordes, G. et al. 1H-Nuclear Magnetic Resonance (NMR) Studies on the Inclusion Complex of Prostaglandin El (PGE1 with α-Cyclodextrin. Pharm Res 9, 575–577 (1992). https://doi.org/10.1023/A:1015865002470

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  • DOI: https://doi.org/10.1023/A:1015865002470

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