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  • 1
    Electronic Resource
    Electronic Resource
    Uncoupling Protein 3: Its Possible Biological Role and Mode of Regulation in Rodents and Humans (1999)
    Springer
    Journal of bioenergetics and biomembranes 31 (1999), S. 467-473 
    Details
    ISSN: 1573-6881
    Keywords: Uncoupling proteins ; fatty acids ; skeletal muscle ; brown adipose tissue ; obesity ; thermogenesis ; gene expression
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Physics
    Notes: Abstract The recently discovered uncoupling protein 3 (UCP3) is highly homologous to the mitochondrialinner membrane protein UCP1, which generates heat by uncoupling the respiratory chainfrom oxidative phosphorylation. The thermogenic function of UCP1 protects against cold andregulates the energy balance in rodents. We review in vitro studies investigating the uncouplingactivity of UCP3 and in vivo studies, which address UCP3 gene expression in brown adiposetissue and skeletal muscle under various metabolic conditions. The data presented are, for themost, consistent with an uncoupling role for UCP3 in regulatory thermogenesis. We alsodiscuss mediators of UCP3 regulation and propose a potential role for intracellular fatty acidsin the mechanism of UCP3 modulation. Finally, we hypothesize a role for UCP3 in themetabolic adaptation of the mitochondria to the degradation of fatty acids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1005448423731
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  • 2
    Electronic Resource
    Electronic Resource
    An alternative approach for gene transfer in trees using wild-typeAgrobacterium strains (1991)
    Springer
    Plant molecular biology 17 (1991), S. 441-452 
    Details
    ISSN: 1573-5028
    Keywords: Agrobacterium ; crown gall ; poplar ; tree transformation ; wild cherry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Micropropagated shoots of three forest tree species, poplar (Populus tremula × P.alba), wild cherry (Prunus avium L.) and walnut (Juglans nigra × J. regia), were inoculated each with six different wild-typeAgrobacterium strains. Poplar and wild cherry developed tumors that grew hormone-independently, whereas on walnut, gall formation was weak. On poplar and wild cherry, tumors induced by nopaline strains developed spontaneously shoots that had a normal phenotype and did not carry oncogenic T-DNA. From these observations, we have established a co-inoculation method to transform plants, using poplar as an experimental model. The method is based on inoculation of stem internodes with anAgrobacterium suspension containing both an oncogenic strain that induces shoot differentiation and a disarmed strain that provides the suitable genes in a binary vector. We used the vector pBI121 carryingneo (kanamycin resistance) anduidA (β-glucuronidase) genes to facilitate early selection and screening. Poplar plants derived from kanamycin-resistant shoots that did not carry oncogenic T-DNA, were shown to contain and to expressneo anduidA genes. These results suggest that wild-typeAgrobacterium strains that induce shoot formation directly from tumors can be used as a general tool for gene transfer, avoiding difficult regeneration procedures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00040638
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  • 3
    Electronic Resource
    Electronic Resource
    Characteristics and careers of Canadian university presidents (1981)
    Springer
    Higher education 10 (1981), S. 335-351 
    Details
    ISSN: 1573-174X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Nature of Science, Research, Systems of Higher Education, Museum Science
    Notes: Abstract This “statistical” study of Canadian university presidents was prompted by the discovery that there is no systematic demographic information available on university administrators in Canada. The vitae of 98 current Canadian university presidents and their immediate predecessors were collected and statistics such as age and length of tenure were compared with those of American counterparts. The Canadian university presidents assumed office at about 49 years of age and held office for about eight years. They tend to be born in geographical proximity to the institution they will head and to “circle” it geographically during their careers. A former association with the University of Toronto, either as a student or teacher, was common. There appears to be a career ladder which includes a decanal and/or vice-presidential position, particularly in central Canada; few presidents move to a second presidency, although several move into what might be termed an “academic superstructure.” Few Canadian presidents majored in the field of Education as a student or teacher and there is generally poor representation from the Arts as compared to the U.S.; on the other hand, the “hard sciences” are well represented. The implications of these tendencies are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00139565
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