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  • 1
    Electronic Resource
    Electronic Resource
    Concentrations of Mn, Fe, Cu, Zn and Cd in the mesopelagic decapod Systellaspis debilis from the East Atlantic Ocean (1985)
    Springer
    Marine biology 87 (1985), S. 285-288 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Specimens of the oceanic decapod Systellaspis debilis were collected from six sites in the East Atlantic Ocean between 1970 and 1984, and were analysed for Mn, Fe, Cu, Zn and Cd. The data confirm that there are small but significant differences in mean metal concentrations from some sites which showed no obvious pattern in relation to geographic location of the samples. As a result, ranges of site means are quoted as “baseline” levels for each metal (μg g-1 dry wt): 2.3 to 2.9 μg Mn g-1, 31.2 to 77.8 μg Fe g-1, 25.9 to 83.4 μg Cu g-1, 41.9 to 92.9 μgZn g-1, 11.1 to 31.8 μg Cd g-1. The concentration of cadmium in S. debilis from all sites was raised relative to cadmium concentrations reported for coastal decapods, perhaps as a result of dietary enrichment. Metal accumulation may provide useful information for understanding the complex feeding behaviour of many oceanic animals.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00397807
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  • 2
    Electronic Resource
    Electronic Resource
    Some body fluid characteristics of the Antarctic fish, Trematomus bernacchii (1968)
    Springer
    Marine biology 1 (1968), S. 269-276 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract An examination of some characteristics of the blood plasma and urine of Trematomus bernacchii, an Antarctic fish, shows that at least in certain seasons the freezing points of these fluids are adjusted in response to environmental temperature. During October and November, freezing point of the urine was found to be about 0.7°C higher than that of the water. Adjustment of freezing point is seen to be intimately related to chloride concentration. At high temperatures magnesium concentration in the urine may be quite high; sodium replaces magnesium under cold stress. During cold stress, sodium and chloride move into the urine independently of each other.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00360775
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  • 3
    Electronic Resource
    Electronic Resource
    The occurrence of wax esters in crustaceans from the North-east Atlantic Ocean (1972)
    Springer
    Marine biology 16 (1972), S. 102-107 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The lipids of 2 species and 1 group of copepods, 4 species of euphausiids, 2 species of mysids, and 6 species of decapods, taken from different depths in the North-eastern Atlantic Ocean and Western Mediterranean Sea, have been analysed specifically for their wax ester content. The mid-water animals living below 500 m contained large amounts of wax ester (30 to 80% total lipid), while those animals living in the upper 600 to 700 m or on the sea floor had only small wax ester fractions (5 to 10% total lipid). It is suggested that the wax esters are laid down by those animals living in areas of low food density, where energy conservation is important, partly to achieve a more neutral buoyancy. In addition, it would appear that wax esters can function as energy reserves.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00347947
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  • 4
    Electronic Resource
    Electronic Resource
    Studies on the lipid metabolism of some oceanic crustaceans (1973)
    Springer
    Marine biology 22 (1973), S. 77-83 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Mid-water, oceanic crustaceans were either fed food labelled with (14C) palmitic acid under controlled conditions, or injected directly with (14C) palmitic acid. Lipid classes and their constituent fatty acids and fatty alcohols were subsequently separated and assayed for radioactivity. Significant levels of radioactivity were present in the 16:01 alcohols and 18:1 acids of wax esters, and in the 16:0/16:1, 18:0/18:1, 20:5 and 22:6 acids of both triglycerides and phospholipids. It was concluded that these crustaceans were capable of biosynthesis of wax esters and higher polyunsaturated fatty acids.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388913
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  • 5
    Electronic Resource
    Electronic Resource
    Biosynthesis of wax esters in oceanic crustaceans (1978)
    Springer
    Marine biology 46 (1978), S. 315-320 
    Details
    ISSN: 1432-1793
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Slices from the hepatopancreas of various oceanic curstaceans incorporated radioactivity into wax esters from 14C glucose and 14C aspartic acid to a lesser extent and from 14C palmitic acid to a much greater extent. Radioactivity was incorporated from 14C palmitic acid into both fatty acid and fatty alcohol moieties of wax esters, the percentage of total radioactivity present in alcohol moieties being greater in deep-living than in shallow-living species. Cell-free preparations from the hepatopancreas but not from muscle, supplemented with ATP and reduced pyridine nucleotides, incorporated radioactivity from 1-14C palmitoyl Coenzyme A into both fatty alcohol and fatty acid moieties of wax esters. Incorporation into fatty alcohol was NADPH- rather than NADH-specific. Preparations from deep-living species had a greater percentage of total radioactivity in the fatty alcohol moieties of wax esters than preparations from shallow-living species. We conclude that the level of wax esters in a given species is correlated with the rate at which the species biosynthesises these lipids de novo; deep-living species have higher rates of wax ester biosynthesis and higher levels of wax esters than shallow-living species. The results support the thesis that wax esters in oceanic crustaceans are derived largely from the animals' internal biosynthetic activities, presumably in response to particular biochemical and/or physiological requirements, rather than from their diets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00391402
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  • 6
    Electronic Resource
    Electronic Resource
    Interference from digoxin-like immunoreactive substance(s) in commercial digoxin kit assay methods (1990)
    Springer
    European journal of clinical pharmacology 39 (1990), S. 359-363 
    Details
    ISSN: 1432-1041
    Keywords: digoxin ; immunoassay ; analytical interference ; therapeutic drug monitoring
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have examined the current state of interference by digoxin-like immunoreactive substance(s) (DLIS) in 10 commercially available digoxin assay methods, ie 5 radioimmunoassays (RIA) and 5 non-radioactive immunoassays. Fifty-five specimens of maternal venous blood (30 from third trimester pregnancy and 25 at delivery) and 32 cord samples from their offspring were tested (none of the subjects being medicated with digoxin). The results demonstrated a wide range of DLIS interference with values up to 1.1 μg·l−1 being obtained in the cord blood specimens. Of the methods tested the “Coat-a Count” RIA (Diagnostic Products Corporation) and the EMIT column method (Syva) run on the Cobas MIRA (Roche) consistently showed the least interference with respect to all 3 sources of specimens. The Delfia Method (LKB/Wallac) consistently showed the greatest crossreactivity with DLIS. The present study thus demonstrates that DLIS interference persists in several commercial digoxin methods and suggests that the use of data obtained from such methods may compromise patient management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315410
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  • 7
    Electronic Resource
    Electronic Resource
    Disposition of epirubicin and metabolites with repeated courses to cancer patients (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 481-487 
    Details
    ISSN: 1432-1041
    Keywords: Epirubicin ; pharmacokinetics ; plasma concentrations ; cancer patients
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Thirteen cancer patients were studied following a total of 41 courses of epirubicin (EPI) (38–50 mg·m−2, mean 49.2 mg·m−2, administered by a 60 min infusion), together with other cancer chemotherapeutic agents. The aim was to consider the disposition of EPI and metabolites following subsequent courses as it has been reported that doxorubicin (the 4′-epimer parent of EPI) clearance is increased following the first administration. We have observed that EPI-glucuronide accounted for a mean 78.0%, epirubicinol 0.2% and epirubicinol-glucuronide 19.3% and that parent EPI accounted for only 2.4% of the EPI-compounds measured (mean of all patients and courses) for the 3 h period immediately following the infusion. These data confirm the rapid metabolism of EPI and the dominance of the glucuronidation metabolite pathway (which is not available to doxorubicin) and are compared with the metabolite profile observed in other reports. Large inter- and intra-individual variability in area under the plasma concentration/time curve were observed with no clear evidence of any consistent directional trend for such fluctuations, suggesting that factors contributing to EPI disposition are multivariate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315227
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  • 8
    Electronic Resource
    Electronic Resource
    Digoxin-like immunoreactive substance levels in cord blood obtained from twins (1991)
    Springer
    European journal of clinical pharmacology 40 (1991), S. 199-200 
    Details
    ISSN: 1432-1041
    Keywords: Digoxin-like immunoreative substance (DLIS) ; cord blood ; twins
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00280079
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  • 9
    Electronic Resource
    Electronic Resource
    The effect of renal and hepatic impairment and of spironolactone on digoxin immunoassays (1988)
    Springer
    European journal of clinical pharmacology 34 (1988), S. 233-239 
    Details
    ISSN: 1432-1041
    Keywords: digoxin ; spironolactone ; immunoassay ; cross-reactivity ; therapeutic monitoring ; assay inaccuracy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effect of renal and/or hepatic dysfunction, and of concomitant spironolactone therapy, on seven commercial digoxin assays was evaluated in 45 patients taking both these drugs, and a comparison made with the digoxin concentrations measured using the same assays in 30 patients taking digoxin in the absence of spironolactone. The study showed that increasing renal dysfunction resulted in increasing inaccuracy in assay results with the methods tested. The influence of concomitant spironolactone was to produce a further distortion, which was shown to be additive in patients with impaired renal and/or liver function. The results highlight the unresolved specificity problems which persist in many, if not all, of the immunoassays currently offered to clinical laboratories which, if not recognised, could significantly influence digoxin therapy and patient management.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00540949
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  • 10
    Electronic Resource
    Electronic Resource
    Some factors influencing water loss from grasses during conservation (1973)
    Springer
    International journal of biometeorology 17 (1973), S. 407-410 
    Details
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01554074
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