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  • Articles  (17)
  • Springer  (17)
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  • Articles  (17)
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  • 1
    Electronic Resource
    Electronic Resource
    Renal vascular reactivity to ATP in hyper- and hypothyroid rats (1996)
    Springer
    Cellular and molecular life sciences 52 (1996), S. 225-229 
    Details
    ISSN: 1420-9071
    Keywords: Hyperthyroidism ; hypothyroidism ; vasodilation ; vasoconstriction ; adenosine triphosphate (ATP) ; isolated kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of adenosine triphosphate (ATP) on the renal vasculature of isolated kidneys from control, hyper- and hypothyroid rats were characterized. ATP responsiveness was evaluated in basal tone and in raised tone (phenylephrine 10−6 M) preparations. These responses were compared with those obtained with barium chloride or sodium nitroprusside (SNP), used respectively as nonreceptor agonists for vasoconstriction or vasodilation. In preparations at basal tone, ATP produced dose-related vasoconstriction, which was increased in hyperthyroid kidneys, and was severely attenuated in kidneys from hypothyroid rats. In raised tone preparations from control rats ATP produced a dual response: vasoconstriction at low doses, which declined with increasing doses to give way to vasodilator responses; biphasic responses were found in some kidneys. Hyperthroid kidneys showed increased pressor responses and a vasodilator response similar to those seen in kidneys from control rats. However, in hypothyroid kidneys the vasodilator response was abolished. The responses to barium chloride and to SNP were significantly increased and decreased in hyper- and hypothyroid kidneys, respectively; vasoconstrictor responses to SNP were also found in hypothyroid kidneys. Hence the abnormal responses to ATP observed in both thyroid dysfunctions may be partially explained by unspecific alterations in the contractile machinery of the renal vasculature in these kidneys. However, ATP responsiveness (vasoconstriction at low tone and vasodilation at raised tone) was more severely affected in hypothyroid kidneys, suggesting that purinergic (P2X and P2Y) receptor activity may be decreased in these organs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01920711
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  • 2
    Electronic Resource
    Electronic Resource
    Analysis of the human Sonic Hedgehog coding and promoter regions in sacral agenesis, triphalangeal thumb, and mirror polydactyly (1998)
    Springer
    Human genetics 〈Berlin〉 102 (1998), S. 387-392 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The human Sonic Hedgehog gene (SHH) is one of the vertebrate homologs related to the Drosophila segment polarity gene hedgehog. The entire coding and promoter region of the SHH gene, including 2 kb 5’ of the transcriptional start site has been screened for mutations in families with autosomal dominant sacral agenesis and autosomal dominant triphalangeal thumb, two conditions previously known to be linked to 7q36. We have also studied the SHH gene in five families with mirror polydactyly associated with tibial hemimelia and in 51 unrelated patients with neural tube defects. Except for two sequence variants in exon 3, no mutations were found in these disease categories.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050709
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  • 3
    Electronic Resource
    Electronic Resource
    Photocycloaddition of 2,3-dimethylmaleimide to selenophene and 3,4-dimethylselenophene (1994)
    Springer
    Monatshefte für Chemie 125 (1994), S. 1153-1158 
    Details
    ISSN: 1434-4475
    Keywords: Photocycloaddition ; Selenophene ; Dimethylmaleimide ; Benzophenone photosensitized cycloaddition
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Die benzophenonsensitivierte Photocycloaddition von 2,3-Dimethylmaleimid an Selenophen und 3,4-Dimethylselenophen wurde durchgeführt, um erstens die Photoadditionsreaktionen von Methylmaleinsäureanhydridderivaten an Selenophen allgemein zu studieren und um zweitens die Zusammensetzung der bei der Reaktion gebildeten Produktgemische erneut zu untersuchen. Zusätzich zu dem bei früheren Arbeiten gefundenen 1:1-Addukt werden drei geometrische Isomere für das 2:1 — Addukt (2 Moleküle Maleimid und 1 Molekül Selenophen oder 3,4-Dimethylselenophen) vorgeschlagen.
    Notes: Summary The benzophenone sensitized photocycloaddition of 2,3-dimethylmaleimide to selenophene and 3,4-dimethylselenophene was carried out first to generalize the photoaddition reaction of methylmaleic anhydride derivatives to selenophene, using this time the nitrogen analogue, and second to reexamine the composition of the product mixture formed in the reaction. It was found that in adition to the 1:1 adduct isolated in previous investigations, three geometrical isomers may be proposed for the 2:1 adduct (two molecules of maleimide of one of selenophene or its methyl derivative).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811523
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  • 4
    Electronic Resource
    Electronic Resource
    A linkage map with RFLP and isozyme markers for almond (1995)
    Springer
    Theoretical and applied genetics 91 (1995), S. 964-971 
    Details
    ISSN: 1432-2242
    Keywords: Almond ; Prunus amygdalus ; Isozymes ; RFLPs ; Genetic maps
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Inheritance and linkage studies were conducted with seven isozyme genes and 120 RFLPs in the F1 progeny of a cross between almond cultivars ‘Ferragnes’ and ‘Tuono’. RFLPs were detected using 57 genomic and 43 cDNA almond clones. Eight of the cDNA probes corresponded to known genes (extensin, prunin (2), α-tubulin, endopolygalacturonase, oleosin, actin depolymerizing factor and phosphoglyceromutase). Single-copy clones were found more frequently in the cDNA (65%) than in the genomic libraries (26%). Two maps were elaborated, one with the 93 loci heterozygous in ‘Ferragnes’ and another with the 69 loci heterozygous in ‘Tuono’. Thirty-five loci were heterozygous in both parents and were used as bridges between both maps. Most of the segregations (91%) were of the 1∶1 or 1∶1∶1∶1 types, and data were analyzed as if they derived from two backcross populations. Eight linkage groups covering 393 cM in ‘Ferragnes’ and 394 in ‘Tuono’ were found for each map. None of the loci examined in either map was found to be unlinked. Distorted segregation ratios were mainly concentrated in two linkage groups of the ‘Ferragnes’ map.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223907
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  • 5
    Electronic Resource
    Electronic Resource
    A stylar ribonuclease assay to detect self-compatible seedlings in almond progenies (1999)
    Springer
    Theoretical and applied genetics 99 (1999), S. 800-810 
    Details
    ISSN: 1432-2242
    Keywords: Key words Almond ; Compatibility ; Genetics ; Prunus dulcis ; Ribonucleases
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract  Six almond progenies, each the product of a cross between a self-compatible and a self-incompatible parent, were analysed for stylar ribonucleases. Proteins were extracted and separated using non-equilibrium pH gradient electrofocusing (NEPHGE), and the gels were stained for ribonuclease activity. Most seedlings showed either two principal bands, interpreted as corresponding to two incompatibility alleles, or a single band. The seedlings were also bagged in the field at flowering time to determine fruit set after selfing, and some were also examined for the growth of pollen-tubes in selfed styles using UV fluorescence microscopy. With very few exceptions, those seedlings showing single-banded zymograms were found to be self-compatible according to field and microscope studies, and those with two bands were found to be self-incompatible. We conclude that the allele for self-compatibility in almond does not code for ribonuclease activity and that the ribonuclease isoenzyme assay is a convenient technique for predicting self-compatibility in segregating progenies. A novel band in two derivatives of ’Ferrastar’ was ascribed to a new incompatibility allele, S 10 .
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001220051299
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  • 6
    Electronic Resource
    Electronic Resource
    Methimazole treatment reduces cardiac hypertrophy and mortality without a concomitant reduction in blood pressure in established Goldblatt two-kidney one clip hypertension (1992)
    Springer
    Cellular and molecular life sciences 48 (1992), S. 755-758 
    Details
    ISSN: 1420-9071
    Keywords: Goldblatt two-kidney one clip hypertension ; methimazole ; hypothyroidism ; relative cardiac hypertrophy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effects of methimazole, and antithyroid drug, on blood pressure and other parameters were evaluated in the established phase of Goldblatt two-kidney one clip (G2K-1C) hypertension. Methimazole was administered via drinking water for five weeks, starting five weeks after hypertension had been induced. After this period of treatment, similarly high blood pressures were observed in methimazole-treated and non-treated G2K-1C rats, despite the fact that a hypothyroid state had been achieved in methimazole-treated rats. Methimazole-treated G2K-1C rats showed reductions in heart rate, ventricular weight, ventricular/body weight ratio and mortality in comparison with rats not treated with methimazole. These results clearly demonstrate that hypothyroidism induced by methimazole: a) does not reverse G2K-1C hypertension, but b) improves the rate of survival and c) reduces relative cardiac hypertrophy, possibly by the reduction in cardiac work observed in Goldblatt hypothyroid rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02124296
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  • 7
    Electronic Resource
    Electronic Resource
    Vascular reactivity in chronic Goldblatt two kidney-one clip hypertensive rats (1990)
    Springer
    Cellular and molecular life sciences 46 (1990), S. 868-869 
    Details
    ISSN: 1420-9071
    Keywords: Goldblatt two kidney-one clip hypertension ; vascular reactivity ; noradrenaline ; vasopresin ; angiotensin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary We studied the possible contribution of increased vascular reactivity in the chronic phase of Goldblatt two kidney-one clip hypertension. Vascular reactivity was evaluated in aortic strips from hypertensive rats (16 weeks after inducing hypertension) and age-matched control rats. The findings were: a) increased sensitivity to vasopressin in the aortic tissue of hypertensive rats, b) a similar response to angiotensin II, noradrenaline and KCl in hypertensive and control rats, and c) reduced maximal response to angiotensin II compared with other vasoconstrictors in both groups of rats. These results suggest a possible role for vasopressin in the chronic phase of this model of hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01935541
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  • 8
    Electronic Resource
    Electronic Resource
    Photocycloaddition of 2-benzoylthiophene to methylmaleic anhydrides (1996)
    Springer
    Monatshefte für Chemie 127 (1996), S. 529-536 
    Details
    ISSN: 1434-4475
    Keywords: 2-Benzoylthiophene ; Photocycloaddition ; Methylmaleic anhydrides
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Aus 2-Benzoylthiophen entstehen unter direkter Bestrahlung mit Licht von Wellenlängen 〉 300 nm in Anwesenheit von Methylmaleinsäureanhydriden [2 + 2]-Cycloaddukte. Die Photoreaktion erfolgt an den C=C-Bindungen des Thiophenrings und des Anhydrids.
    Notes: Summary Upon direct irradiation with light of wavelengths greater than 300 nm, 2-benzoylthiophene undergoes [2 + 2] cycloadditions withmono- anddi-methylmaleic anhydrides involving the C=C bond of the latter and the benzoyl-substituted thiophene C=C bond.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00807078
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  • 9
    Electronic Resource
    Electronic Resource
    Enzymatic treatment to enhance carotenoid content in dehydrated marigold flower meal (1997)
    Springer
    Plant foods for human nutrition 50 (1997), S. 163-169 
    Details
    ISSN: 1573-9104
    Keywords: Marigold ; Tagetes erecta ; Enzymatic extraction ; Carotenoids ; Lutein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Abstract The effect of enzymatic treatments using a commercial enzyme (Econase-cep at pH 5.0 and 0.1% w/w concentration) at different levels of dehydrated marigold meal (5, 10, 15 and 20% dry weight), to enhance carotenoid extraction, was evaluated. The AOAC method consisting of a simultaneous extraction and saponification by using hexane-ethanol-acetonetoluene (10:6:7:7 v/v) and metanolic KOH (40% w/v) was used to evaluate the carotenoid content. The measurement of carotenoids was also carried out in samples in which the water soluble compounds were previously eliminated (AOAC-H2O). Total carotenoids ranged from 11.4 to 17. 4 g/kg and 18 to 24.7 g/kg of control and treated marigold meal, respectively. Highest amount of carotenoids were noted when 5% level of treated meal was used.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02436035
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  • 10
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    Low MHC variation in the endangered Galápagos penguin (Spheniscus mendiculus) (2007)
    Springer
    Details
    Publication Date: 2007-04-25
    Print ISSN: 0093-7711
    Electronic ISSN: 1432-1211
    Topics: Biology , Medicine
    Published by Springer
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