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  • 1
    Electronic Resource
    Electronic Resource
    Arachidonic acid and the control of body pattern inHydra (1993)
    Springer
    Development genes and evolution 202 (1993), S. 70-76 
    Details
    ISSN: 1432-041X
    Keywords: Arachidonic acid ; HETE ; Protein kinase C ; Lipoxygenase ; Hydra ; Coelenterates
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Repeated stimulation ofHydra magnipapillata with the diacylglycerol (DG) 1,2-sn-dioctanoylglycerol (diC8) induces an increase in positional value and eventually the development of ectopic heads. Upon stimulation, the polyps release [14C]-arachidonic acid from previously labelled endogenous sources. Arachidonic acid (AA) is not released into the external medium but remains within the animal, AA, linoleic acid and their lipoxygenase products were identified by gas chromatography-mass spectrometry. Several metabolites were found, most abundantly 12-HETE (hydroxy-eicosa-tetraenoic acid), 8-HETE, 9-HODE (hydroxy-octadecadienoic acid), and 13-HODE; this is the first evidence of their presence in coelenterates. Externally applied AA causes ectopic head formation, though less effectively than diC8. When administered simultaneously, (diC8) and AA, which both are known to activate protein kinase C (PKC), act synergistically in inducing ectopic head formation. Since released endogenous AA can spread in tissues, it may mediate a temporal and spatial extension of PKC activation and, hence, broaden the range in which positional value increases. However, in addition to the activation of PKC, the generation of AA metabolites appears to be essential for the induction of ectopic head formation, since not only a selective inhibitor of PKC, chelerythrine, but also an inhibitor of lipoxygenases, NDGA (nordihydroguaiaretic acid), significantly reduces the effectiveness of both AA and DG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00636531
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  • 2
    Electronic Resource
    Electronic Resource
    The haemodynamic effects and pharmacokinetics of intravenous nicorandil in healthy volunteers (1993)
    Springer
    European journal of clinical pharmacology 44 (1993), S. 27-33 
    Details
    ISSN: 1432-1041
    Keywords: Nicorandil ; vasodilator ; tolerance study ; blood pressure ; pharmacokinetics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the effects of intravenous nicorandil, a mixed arterial and venous vasodilator, in 48 healthy volunteers. Nicorandil (20, 28, 39, 54, 74, 103, 144, or 200 μg·kg−1) or placebo were given over 5 min to subjects supine (16 subjects, 2 doses) or sitting (32 subjects, 1 dose) in a single-blind crossover design. Electro-cardiographic intervals, blood pressure, and heart rate were measured before and for 8 h after dosing. Blood and urine safety laboratory studies were also performed before and after dosing. All intravenous infusions of nicorandil and placebo were well tolerated and there were no clinically important safety concerns. The most frequent adverse event after nicorandil was headache (24 events by 19 subjects), although its occurrence was not strictly dose related. One subject experienced transient symptomatic hypotension (144 μg·kg−1). Mean plasma nicorandil concentrations were dose-related and fell with a half-life of 0.7 to 1.2 h. Systemic clearance and volume of distribution tended to decrease as dose increased. Sitting subjects showed marginally lower (〈20%) systemic clearances and larger values of Cmax and AUC. Nicorandil produced dose-related reductions in blood pressure, with consistent statistically significant differences from placebo after the 144 and 200 μg·kg−1 doses. The falls in blood pressure were greater for diastolic pressure and in this supine position. At 200 μg·kg−1, the mean falls in systolic/diastolic pressures (mm Hg) during the first hour were 10.9/14.7 supine and 6.1/9.1 sitting; systolic pressure returned to baseline after 8 h and diastolic pressure after 4 h. Heart rate increased transiently (mean peak increase of 17–24 bpm at the end of the 144 and 200 μg·kg−1 infusions). Blood pressure and heart rate changes over time were statistically significantly correlated with plasma nicorandil concentrations. Individual areas under the blood pressure and heart rate change curves likewise correlated with plasma concentration curve areas.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315276
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  • 3
    Electronic Resource
    Electronic Resource
    The pharmacokinetics and haemodynamic effects of continuous nicorandil infusion in healthy volunteers (1993)
    Springer
    European journal of clinical pharmacology 45 (1993), S. 437-443 
    Details
    ISSN: 1432-1041
    Keywords: Nicorandil ; vasodilator ; continuous infusion ; blood pressure ; pharmacokinetics ; healthy volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary We have studied the pharmacokinetics and haemodynamic effects of nicorandil after a 12-h infusion. Nicorandil is a mixed vasodilator combining the actions of a nitrate and a potassium channel opener. Nicorandil was infused for 12 h in 21 healthy volunteers at rates of 0.05, 0.10, and 0.20 μg·kg−1·min−1 using a placebo controlled, crossover design. Systemic blood pressure, heart rate, electrocardiographic (ECG) intervals, and cardiac output (impedance cardiography) were measured supine and standing. Dose-related, steady-state plasma nicorandil concentrations occurred within 3 to 4 h. Nicorandil's pharmacokinetics were linear with dose. Four 0.20 μg·kg−1·min−1 nicorandil infusions were terminated early primarily because of moderate or severe headaches. There were no safety concerns (ECG intervals, laboratory assays). Blood pressure fell versus placebo only in the standing position and heart rate increased slightly (not significant). That is, standing blood pressure in the 6 to 12 h interval fell from baseline 8.0*/6.8, 1.6/5.1, and 9.8*/7.9* mmHg (systolic/diastolic, *=P〈0.05 versus placebo) at 0.05, 0.10, and 0.20 μg·kg−1·min−1 respectively. Cardiac output increased slightly above placebo at lower doses. Haemodynamic changes correlated poorly with plasma nicorandil concentrations. Similar total doses were less well-tolerated when extended over 12 h. We saw no evidence of pharmacodynamic tolerance to nicorandil within 12 h.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00315515
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  • 4
    Electronic Resource
    Electronic Resource
    JAPANESE MANAGEMENT: COPING WITH BRITISH INDUSTRIAL RELATIONS (1986)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of management studies 23 (1986), S. 0 
    Details
    ISSN: 1467-6486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6486.1986.tb00935.x
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  • 5
    Electronic Resource
    Electronic Resource
    A COMPARISON OF QUALITY ATTITUDES IN THE USA AND JAPAN: EMPIRICAL EVIDENCE (1991)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of management studies 28 (1991), S. 0 
    Details
    ISSN: 1467-6486
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Economics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1467-6486.1991.tb00981.x
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  • 6
    Electronic Resource
    Electronic Resource
    Alfalfa establishment without tillage as influenced by insecticide and vegetation suppression (1985)
    Oxford, UK : Blackwell Publishing Ltd
    Grass and forage science 40 (1985), S. 0 
    Details
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Conventional alfalfa (Medicago sativa L.) establishment methods may create considerable potential for erosion. Conservation tillage practices that result in stand establishment without disturbing the soil greatly would be beneficial in reducing soil losses. Thus, field experiments were conducted to evaluate the success of alfalfa establishment without tillage in a perennial grass sod. Variables included rate of carbofuran (2, 3-dihydro-2, 2-dimethyl-7 benzofuranyi methylcarbamate) insecticide and control of existing vegetation with chemicals. Establishment without tillage was compared with a conventional method of establishment. Carbofuran at 1.1 kg ha−1 applied in the row with the seed, when compared with a control, increased yields during the year of planting but no response was observed in the year after seeding. Yields of alfalfa established without tillage using either glyphosate (N-(phosphonomethyl)glycine) or paraquat (1,1-dimethyl-4, 4-bipyridinium chloride) for sod suppression were equivalent to or better than yields obtained from conventional sowings except for the 2 April sowing. Paraquat was more effective for tall fescue (Festuca arundinacea Schreb.) suppression when applications were made on 26 April after spring tiller emergence was complete than on 2 April when some of the tillers may have been protected from the spray by basal sheath tissue.Broadcast application of paraquat resulted in higher alfalfa yields and decreased non-alfalfa components due to more complete sod suppression than application in bands over the row.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2494.1985.tb01779.x
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  • 7
    Electronic Resource
    Electronic Resource
    A TEMPERATURE INDICATOR FOR USE DURING OVEN-DRYING OF HERBAGE (1974)
    Oxford, UK : Blackwell Publishing Ltd
    Grass and forage science 29 (1974), S. 0 
    Details
    ISSN: 1365-2494
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: The drying of small herbage samples should be as rapid as possible so as to limit respiratory loss and enzymatic interconversions, especially if certain nonstnictnral carbohydrates are to be assayed. An inexpensive thermo-switch is described that indicates the time required to heat a mass of tissue in an oven to a given temperature. The time required to heat green herbage to a temperature (55°C) that will inactivate respiratory enzymes can be determined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2494.1974.tb01266.x
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  • 8
    Electronic Resource
    Electronic Resource
    A melon genotype with superior competence for regeneration and transformation (2003)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 122 (2003), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Transformation efficiency of melon is low and is still regarded as a challenge. In this paper, the regeneration and transformation response of ‘BU-21/3′, a newly characterized melon breeding line, is described. The line seems to be superior in this regard to previously evaluated genotypes. Agrobacterium-mediated delivery of the GUS or GFP reporter genes into cotyledon explants was used to evaluate efficiency of transient and stable transformation. Good transient expression was observed, and stable transformation frequencies of 0.4-1.5 transgenic shoots per explant were obtained. Transgenic plantlets were transferred to a contained greenhouse as early as 8-10 weeks after transformation. Transgenic plants are fertile and exhibit a true-to-type phenotype. The ‘BU-21/3’ line may become a useful tool for the facilitation of transgenic breeding in melon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1439-0523.2003.00764.x
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  • 9
    Electronic Resource
    Electronic Resource
    THE ACETYLCHOLINE SYSTEM IN PERIPHERAL NERVE (1967)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 144 (1967), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1967.tb53789.x
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  • 10
    Electronic Resource
    Electronic Resource
    Evaluation of a standardized F1 capsular antigen capture ELISA test kit for the rapid diagnosis of plague (2004)
    Oxford, UK : Blackwell Publishing Ltd
    FEMS immunology and medical microbiology 41 (2004), S. 0 
    Details
    ISSN: 1574-695X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology , Medicine
    Notes: Rapid detection of soluble F1 capsular antigen in serum, bubo fluid or urine of patients proved to be a valuable tool in the presumptive diagnosis of plague.We evaluated a F1 capsular antigen capture ELISA resembling a commercially available test kit. The minimal detectable concentration was 4 ng/ml. The specificity was 100% when investigating 47 sera from healthy Malagasy subjects and 98.4% when 365 sera from German blood donors were studied. Sensitivity was determined on sera (n=11) and buboes (n=18) from bacteriologically confirmed Malagasy plague patients. Sensitivity was 90.1% for serum and 100% for buboes.A standardized F1 capsular antigen capture ELISA test kit might be well suited for the early detection of plague particularly in non-endemic areas where clinical microbiological laboratories have only limited access to alternative techniques for rapid identification of Yersinia pestis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1016/j.femsim.2004.02.005
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