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  • Springer  (673)
  • American Chemical Society  (520)
  • American Institute of Physics (AIP)  (95)
  • 1995-1999  (650)
  • 1985-1989  (554)
  • 1940-1944  (84)
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  • 1
    ISSN: 1520-4995
    Quelle: ACS Legacy Archives
    Thema: Biologie , Chemie und Pharmazie
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Cellular and molecular life sciences 52 (1996), S. 597-599 
    ISSN: 1420-9071
    Schlagwort(e): Glutathione ; free radicals ; antioxidants ; oxidant stressors ; buthionine ; menadione
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Using a prokaryote (Escherichia coli) and a metazoa-resembling eukaryote (Ochromonas danica), we surveyed antioxidants which might overcome redox stress imposed by menadione sodium bisulphite (MD) and buthionine sulphoximine (BSO). BSO oxidant stress was evident only inO. danica; MD oxidant stress was evident in both organisms. Glutathione, its precursors, e.g. cysteine, homocysteine, and 2-oxo-4-thiazolidine carboxylic acid, and red blood cells, emerged as prime antioxidants for relieving BSO and MD oxidant stress. BSO and MD oxidant activity and antioxidant-annulling effect inO. danica were judged comparable to those found in animal cells whereas the resultsE. coli were not entirely equivalent. TheO. danica system emerged as a practical, rapid, and useful system for pinpointing oxidant stressors and antioxidants, and shows promise for studies with mammalian systems.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    ISSN: 1432-119X
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract  Growth hormone (GH) exerts its regulatory functions in controlling metabolism, balanced growth and differentiated cell expression by acting on specific receptors which trigger a phosphorylation cascade, resulting in the modulation of numerous signalling pathways dictating gene expression. A panel of five monoclonal antibodies was used in mapping the presence and somatic distribution of the GH receptor by immunohistochemistry in normal and neoplastic tissues and cultured cells of human, rat and rabbit origin. A wide distribution of the receptor was observed in many cell types. Not all cells expressing cytoplasmic GH receptors displayed nuclear immunoreactivity. In general, the relative proportion of positive cells and intensity of staining was higher in neoplastic cells than in normal tissue cells. Immunoreactivity showed subcellular localisation of the GH receptor in cell membranes and was predominantly cytoplasmic, but strong nuclear immunoreaction was also apparent in many instances. Intense immunoreactivity was also observed in the cellular Golgi area of established cell lines and cultured tissue-derived cells in exponential growth phase, indicating cells are capable of GH receptor synthesis. The presence of intracellular GH receptor, previously documented in normal tissues of mostly animal origin, is the result of endoplasmic reticulum and Golgi localisation. Heterogeneity of immunoreactivity was found in normal and neoplastic tissue with a variable range of positive cells. The nuclear localisation of immunoreactivity is the result of nuclear GH receptor/binding protein, identically to the cytosolic and plasma GH-binding protein, using a panel of five monoclonal antibodies against the GH receptor extracellular region. The expression of GH receptors, not only on small proliferating tumour cells such as lymphocytes, but also on well differentiated cells including keratinocytes, suggests that GH is necessary not only for differentiation of progenitor cells, but also for their subsequent clonal expansion, differentiation and maintenance.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    ISSN: 1432-1327
    Schlagwort(e): Key words Superoxide dismutase ; Manganese enzyme ; Crystal structure ; Metalloprotein ; DNA binding
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract  The three-dimensional structure of the manganese-dependent superoxide dismutase (MnSOD) from Escherichia coli has been determined by X-ray crystallography at 2.1 Å resolution. The protein crystallizes with two homodimers in the asymmetric unit, and a model comprising 6528 protein atoms (residues 1–205 of all four monomers), four manganese ions and 415 water molecules has been refined to an R factor of 0.188 (R free 0.218). The structure shows a high degree of similarity with other MnSOD and FeSOD enzymes. The Mn centres are 5-coordinate, trigonal bipyramidal, with His26 and a solvent molecule, probably a hydroxide ion, as apical ligands, and His81, Asp167 and His171 as equatorial ligands. The coordinated solvent molecule is linked to a network of hydrogen bonds involving the non-coordinated carboxylate oxygen of Asp167 and a conserved glutamine residue, Gln146. The MnSOD dimer is notable for the way in which the two active sites are interconnected and a "bridge" comprising His171 of one monomer and Glu170 of the other offers a route for inter-site communication. Comparison of E. coli MnSOD and FeSOD (a) reveals some differences in the dimer interface, (b) yields no obvious explanation for their metal specificities, and (c) provides a structural basis for differences in DNA binding, where for MnSOD the groove formed by dimerization is complementary in charge and surface contour to B-DNA.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Behavioral ecology and sociobiology 23 (1988), S. 105-108 
    ISSN: 1432-0762
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary The loud and elaborate songs of male songbirds are throught to serve in territorial defense and to stimulate reproductive behavior in the female. We report here that in contrast to several other species, song alone is inadequate to induce sexual (lordosis) behavior in female indigo and lazuli buntings (Passerina cyanea and P. amoena); they require a more elaborate stimulus configuration to develop the full expression of sexual receptivity as indicated by a stereotyped copulation solicitation display. A live male must be present near the female, singing must ensue, and in addition a second and unique vocal utterance must be heard by the female; this is a soft buzzy-sounding vocalization, audible for no more than a few meters, not recognized previously as a critical arousal signal of the male songbird repertoire. Females also utter similar soft sounds in an intimate vocal exchange with the male leading to solicitation of copulation.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    ISSN: 1573-5117
    Schlagwort(e): microstratification ; thin layer sampler ; heterogeneous water column ; chemocline ; stratification ; meromixis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract A series of inexpensive, pneumatic thin layer water samplers is described. They can be operated from small boats, and permit sampling at 2.5 cm intervals with little or no disturbance of stratified systems such as oxyclines or redoxclines of meromictic lakes, or microstratification of flagellates in sheltered epilimnia. Some models permit replicate sampling at closely-spaced intervals in a two-dimensional array. Their performance abilities are illustrated with examples of microstratification.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Plant systematics and evolution 151 (1986), S. 175-186 
    ISSN: 1615-6110
    Schlagwort(e): Angiosperms. — Nectar ; amino acids ; pollinators ; sample size ; phylogenetic constraint ; evolutionary significance. — Flora of California
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Approximately 1 500 angiosperm species, in previous papers, have been sampled for the assessment of the amino acids (a. a.) in their nectar. We reaffirm that the findings provide statistically significant data linking differences in the concentration with pollinator type. Flowers that are pollinated by animals that have alternative sources of protein-building a. a.’s show lower a. a. concentration than those that are not. There is a tendency for woody plant nectar a. a.’s to be less concentrated than those of herbaceous plants, but there can be “phylogenetic constraints” which may reduce the correlations of a. a. concentration with pollinator type and with life form. The individual a. a.’s form complements which are qualitatively extremely constant within species. Proline is a normal constituent of many nectars and does not necessarily indicate contamination of the nectar by pollen. Criticism of our findings byGottsberger & al. (1984) is answered by reference to our previous publications and those of other workers, and to the presentation of data from California native species, not published previously. All previous postulates are borne out by these new data with the exception of positive correlations of a. a. concentration with “primitive” and “advanced” floral characteristics taken one at a time, which appear to be inconsistent and are affected strongly by the nature of the family in which they occur. Summary data are provided for families and genera which indicate that high or low a. a. concentration can typify certain families and genera of both relatively “primitive” and relatively “advanced” nature. Needs for future research on an ecosystem basis are quoted.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    ISSN: 1615-6110
    Schlagwort(e): Angiosperms ; Leguminosae ; Mimosoideae ; Acacia terminalis ; Bee- and bird-pollination ; extrafloral nectaries ; intraspecific variation
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Intraspecific variation has been found for several pollination-related characteristics in two isolated populations of the self-incompatible treeAcacia terminalis: floral characteristics including colour and flowering time; style length; size and colour of extrafloral nectaries on the leaf petioles; chemical components of the extrafloral nectar; different taxa of bee pollinators; and frequency differences in bird pollinators. These differences possibly reflect the evolution of two different pollination syndromes within this species.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Publikationsdatum: 1996-06-01
    Print ISSN: 0014-4754
    Thema: Biologie , Medizin
    Publiziert von Springer
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Publikationsdatum: 1985-03-01
    Print ISSN: 0018-8158
    Digitale ISSN: 1573-5117
    Thema: Biologie
    Publiziert von Springer
    Standort Signatur Erwartet Verfügbarkeit
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