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  • Springer  (147)
  • 1985-1989  (49)
  • 1925-1929  (98)
  • 1
    Electronic Resource
    Electronic Resource
    Different biological behavior of AKR lymphoma cells from primary and metastatic tumors (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 404-407 
    Details
    ISSN: 1420-9071
    Keywords: Different malignancy ; primary-metastatic cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary AKR lymphoma cells derived from primary s.c. tumors (PT) and cells from their metastases (MT) were inoculated into recipient mice in order to compare their malignant behavior. A higher malignant potential of MT compared to PT cells was found. The results support the hypothesis that metastasis is a process of selection of cells possessing a potential to metastasize, which preexist in the primary tumor. In the model used, both the selection of ‘variants’ of malignancy and the assay of malignancy were as close as possible to natural tumor progression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02004530
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  • 2
    Electronic Resource
    Electronic Resource
    Besprechungen (1925)
    Springer
    Naturwissenschaften 13 (1925), S. 624-627 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01558907
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  • 3
    Electronic Resource
    Electronic Resource
    Mitteilungen aus verschiedenen Gebieten (1925)
    Springer
    Naturwissenschaften 13 (1925), S. 223-226 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01558887
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  • 4
    Electronic Resource
    Electronic Resource
    Besprechungen (1925)
    Springer
    Naturwissenschaften 13 (1925), S. 13-16 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01558799
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  • 5
    Electronic Resource
    Electronic Resource
    Mitteilungen aus verschiedenen Gebieten (1925)
    Springer
    Naturwissenschaften 13 (1925), S. 201-203 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01558639
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  • 6
    Electronic Resource
    Electronic Resource
    Temperature-jump and voltage-jump experiments at planar lipid membranes support an aggregational (micellar) model of the gramicidin A ion channel (1986)
    Springer
    The journal of membrane biology 89 (1986), S. 23-37 
    Details
    ISSN: 1432-1424
    Keywords: gramicidin A ; ion channel ; lipid membrane ; temperature jump ; voltage jump
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary The kinetics of formation and dissociation of channels formed by gramicidin A and two analogues in planar lipid membranes was studied using a laser temperature-jump technique developed earlier [Brock, W., Stark, G., Jordan, P.C. (1981),Biophys. Chem. 13:329–348]. The time course of the electric current was found to agree with a single exponential term plus a linear drift. In case of gramicidin A the relaxation time was identical to that reported for V-jump experiments [Bamberg, E., Läuger, P. (1973),J. Membrane Biol. 11:177–194], which were interpreted on the basis of a dimerization reaction. The same results were obtained for gramicidin A and for chemically dimerized malonyl-bis-desformylgramicidin. It is therefore suggested that the dimerization represents a parallel association of two dimers to a tetramer. There is evidence that the tetramer, contrary to the presently favored dimer hypothesis, is the smallest conductance unit of an active gramicidin channel. An additional V-jump-induced relaxation process of considerably larger time constant is interpreted as a further aggregation of gramicidin dimers.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01870893
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  • 7
    Electronic Resource
    Electronic Resource
    Muscle models: What is gained and what is lost by varying model complexity (1987)
    Springer
    Biological cybernetics 55 (1987), S. 403-420 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract Three structurally different types of models have evolved over the years to describe muscle-joint systems. The first, based on an input-output analysis of a given task, results in a simple second-order differential equation description that is adequate over a certain movement operating range. The second, based on the classic structural model of Hill (1938), results in a higher-order nonlinear model described by ordinary differntial equations. The third, based on an analysis of the biophysical contractile mechanism, results in a complex partial differential equation description. The advantages and disadvantages of each type of model are considered, based on the criteria of identifying the simplest model that can adequately simulate any fundamental type of human movement without modifying model parameters for different tasks. It is shown that an eighth-order Hill-based antagonistic muscle-joint model is able to satisfy these criteria for a given joint if each of the four basic mechanically-significant non-linearities of the system are included in the model. This same model structure has been used successfully for eight different muscle-joint systems, ranging in size from knee flexion-extension to eye rotation — the only difference between the models is in the parameter values. Second-order models are shown to be task-specific special cases of the input-output behavior of the eighth-order model, while the more complex biophysical models are hypothesized to have insignificant advantages and many disadvantages over the Hill-based model during normal human movement.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00318375
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  • 8
    Electronic Resource
    Electronic Resource
    Late agnoist activation burst (PC) required for optimal head movement: A simulation study (1987)
    Springer
    Biological cybernetics 57 (1987), S. 321-330 
    Details
    ISSN: 1432-0770
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Computer Science , Physics
    Notes: Abstract Fast as possible (time optimal) single joint movements throughout the body are characterized by the triphasic (3 pulse) pattern of activation in the agonist and antagonist muscles. Simulation studies using a sixth order, non-linear model were undertaken to determine the relationship between time optimal movement and three pulse control. Exhaustive exploration of the multidimensional space formed by descriptive parameters of the control signal yielded control signals which drove the model to produce optimal movements. The result of these one to two week computer simulation runs was that if the limb is required to stay close to the target immediately after the end of the control signal, the fastest movements are produced by a three pulse control signal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00338824
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  • 9
    Electronic Resource
    Electronic Resource
    Localisation of reaction centre and light harvesting complexes in the photosynthetic unit of Rhodopseudomonas viridis (1986)
    Springer
    Archives of microbiology 146 (1986), S. 130-133 
    Details
    ISSN: 1432-072X
    Keywords: Bacteriochlorophyll b ; Immuno-electron microscopy ; Light harvesting complex ; Pigment protein complex ; Rhodopseudomonas viridis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The photosynthetic unit of Rhodopseudomonas viridis contains a reaction centre (P960) and a light harvesting complex (B1015). Immune electron microscopy combined with image processing has allowed the central core of the photosynthetic unit to be identified as the reaction centre and the surrounding protein ring as the light harvesting complex. This light harvesting complex, subdivided into twelve subunits was shown to contain 24 bacteriochlorophyll b molecules. A model is presented which may account for the far red shift of the Qy absorption of the bacteriochlorophyll b molecules in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00402339
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  • 10
    Electronic Resource
    Electronic Resource
    The regulation of cytochrome c oxidase of Rhodobacter capsulatus by light and oxygen (1987)
    Springer
    Archives of microbiology 149 (1987), S. 12-18 
    Details
    ISSN: 1432-072X
    Keywords: Oxidase regulation ; Cytochrome c oxidase ; Cytochrome c 2 ; Regulatory DNA sequence ; Rhodobacter capsulatus
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract In order to distinguish between the regulatory effects of oxygen tension and light intensity on cytochrome c oxidase protein and enzymatic activity cells of Rhodobacter capsulatus were shifted from phototrophic (anaerobic, light) growth to aerobic-light, aerobic-dark and to anaerobic-dark conditions, respectively. During shift-experiments the formation of oxidase protein and regulation of oxidase activity was followed by immunological and enzymatic means. The results support the idea, that the formation of oxidase protein is regulated by oxygen tension and light intensity changes, whereas the regulation of oxidase activity seems only to be correlated to the oxygen tension. A DNA sequence involved in the oxygen-dependent regulation of cytochrome oxidase could be identified in the regulation-deficient oxidase mutant H41 of R. capsulatus. Immunological investigations of cytochrome c 2 from mutant H41 demonstrated at the same time the participation of the c 2-polypeptide in the regulation of cytochrome c oxidase.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00423129
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