ISSN:
1420-9071
Keywords:
Different malignancy
;
primary-metastatic cells
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary AKR lymphoma cells derived from primary s.c. tumors (PT) and cells from their metastases (MT) were inoculated into recipient mice in order to compare their malignant behavior. A higher malignant potential of MT compared to PT cells was found. The results support the hypothesis that metastasis is a process of selection of cells possessing a potential to metastasize, which preexist in the primary tumor. In the model used, both the selection of ‘variants’ of malignancy and the assay of malignancy were as close as possible to natural tumor progression.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02004530
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