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  • Institute of Physics  (157)
  • Springer  (102)
  • PANGAEA  (22)
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  • 1
    Electronic Resource
    Electronic Resource
    Pharmacokinetics of cimetidine and its sulphoxide metabolite during haemodialysis (1982)
    Springer
    European journal of clinical pharmacology 21 (1982), S. 325-330 
    Details
    ISSN: 1432-1041
    Keywords: cimetidine ; renal failure ; cimetidine sulphoxide ; pharmacokinetics ; haemodialysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary A single intravenous dose of cimetidine 200mg was administered to 6 patients with severe chronic renal failure one hour prior to haemodialysis. The plasma concentrations of cimetidine and its sulphoxide metabolite at the start of haemodialysis were 2.74±0.12 and 0.76±0.08 µg/ml, and after dialysis for 4h 1.08±0.10 and 0.51±0.08 µg/ml, respectively (mean ± SE). The average haemodialysis clearance (ClHDa) of cimetidine during dialysis was 46–92ml/min at a dialysate flow rate of 320ml/min and blood flow rates in the 6 patients between 160–240ml/min. The mean ClHDa of the sulphoxide metabolite was 44% higher than that of cimetidine, and ranged between 49–148ml/min. During haemodialysis the mean plasma elimination half-life (t1/2) of cimetidine was 3.24h (range 2.08–5.08) and of the sulphoxide metabolite 9.49h (range 4.70–14.39). There was a significant relationship between the elimination rate constant (β) and ClHDa of the sulphoxide metabolite (p〈0.01), but no such relationship was found between β and ClHDa of cimetidine. However, there was a tendency to a relationship between β of cimetidine and the capacity to metabolise the drug, expressed as the ratio between the plasma concentrations of the sulphoxide metabolite and cimetidine after dialysis for 4h. These ratios ranged between 0.23–0.76, and the lowest ratio was seen in the patient with the lowest β value of cimetidine. Thus, the large variations in the plained by differences in their capacity to metabolise the drug. The mean total amount of cimetidine eliminated during dialysis was 27.3mg (range 17.9–31.8), which was 9.0–15.9% of the given dose. Between 12.2–21.2mg (mean 15.3) of the sulphoxide metabolite was eliminated in the dialysate. Major adjustment of the dose of cimetidine on days of dialysis is not necessary.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00637621
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  • 2
    Electronic Resource
    Electronic Resource
    Characterization of the human synaptogyrin gene family (1998)
    Springer
    Human genetics 〈Berlin〉 103 (1998), S. 131-141 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Genomic sequencing was combined with searches of databases for identification of active genes on human chromosome 22. A cosmid from 22q13, located in the telomeric vicinity of the PDGFB (platelet-derived growth factor B-chain) gene, was fully sequenced. Using an expressed sequence tag-based approach we characterized human (SYNGR1) and mouse (Syngr1) orthologs of the previously cloned rat synaptogyrin gene (RATSYNGR1). The human SYNGR1 gene reveals three (SYNGR1a, SYNGR1b, SYNGR1c) alternative transcript forms of 4.5, 1.3 and 0.9 kb, respectively. The transcription of SYNGR1 starts from two different promoters, and leads to predicted proteins with different N- and C-terminal ends. The most abundant SYNGR1a transcript, the 4.5-kb form, which corresponds to RATSYNGR1, is highly expressed in neurons of the central nervous system and at much lower levels in other tissues, as determined by in situ hybridization histochemistry. The levels of SYNGR1b and SYNGR1c transcripts are low and limited to heart, skeletal muscle, ovary and fetal liver. We also characterized two additional members of this novel synaptogyrin gene family in human (SYNGR2 and SYNGR3), and one in mouse (Syngr2). The human SYNGR2 gene transcript of 1.6 kb is expressed at high levels in all tissues, except brain. The 2.2-kb SYNGR3 transcript was detected in brain and placenta only. The human SYNGR2 and SYNGR3 genes were mapped by fluorescence in situ hybridization to 17qtel and 16ptel, respectively. The human SYNGR2 gene has a processed pseudogene localized in 15q11. All predicted synaptogyrin proteins contain four strongly conserved transmembrane domains, which is consistent with the M-shaped topology. The C-terminal polypeptide ends are variable in length, display a low degree of sequence similarity between family members, and are therefore likely to convey the functional specificity of each protein.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050795
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  • 3
    Electronic Resource
    Electronic Resource
    A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3 (1999)
    Springer
    Human genetics 〈Berlin〉 105 (1999), S. 552-559 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract. Chromosomal deletions on 3p have been described in a large number of human tumors, suggesting the presence of a tumor suppressor gene(s). Using an experimental system, called the elimination test, we previously identified a 1 Mb segment, the common eliminated region 1 (C3CER1). C3CER1 was also covered by a PAC contig. Using the sequence of two overlapping PACs from C3CER1, we localized the human KIAA0028 cDNA, encoding the precursor of mitochondrial leucyl-tRNA synthetase. We also characterized a novel human LIM domain-containing gene (LIMD1) and its mouse ortholog (Limd1). LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. The predicted protein sequences of the human and mouse genes reveal three LIM domains located at the C-terminal end, which indicates that they belong to the group 3 of the gene family encoding LIM motifs. We characterized the genomic structure of the human LIMD1 gene and assigned the mouse Limd1 gene to the chromosome 9F subtelomeric region. Both genes are ubiquitously expressed at the mRNA level. The LIM motif has been previously identified in many developmentally important factors from various eukaryotes. These factors have been shown to play a role in intracellular signaling, transcriptional regulation and cellular differentiation during development. The human C3CER1-located LIMD1 gene should therefore be further studied for its possible role in tumor suppression.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004399900188
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  • 4
    Electronic Resource
    Electronic Resource
    The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13 (1997)
    Springer
    Human genetics 〈Berlin〉 100 (1997), S. 611-619 
    Details
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Multiple endocrine neoplasia type 1 (MEN1) is tightly linked to the muscle-type glycogen phosphorylase (PYGM) gene in 11q13. This region of the human genome contains additional disease-related loci implicated in the development of insulin-dependent diabetes mellitus, familial paraganglioma type 2, spinocerebellar ataxia type 5, Bardet-Biedl syndrome and translocation t(11;17) described in B-cell non-Hodgkin’s lymphoma. We approached cloning of candidate disease genes from 11q13 by large-scale genomic sequencing. We obtained 〉 106 kb of sequence around the PYGM gene and established a transcriptional map that includes: (i) two genes previously localized to 11q13, PYGM and a zinc-finger protein (ZFM1) gene; (ii) the germinal center kinase (GCK, human B-lymphocyte serine/threonine protein kinase) gene; (iii) a novel human CDC25-like (HCDC25L) gene; (iv) a dystrophia myotonica protein kinase-like (DMPKL) gene; and (v) a novel ubiquitously expressed gene of unknown function (germinal center kinase- neighboring gene, GCKNG).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s004390050562
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  • 5
    Electronic Resource
    Electronic Resource
    Responses of glomerular filtration, renal blood flow and salt-water handling to acute cardioselective and non-selective β-adrenoceptor blockade in essential hypertension (1989)
    Springer
    European journal of clinical pharmacology 36 (1989), S. 343-345 
    Details
    ISSN: 1432-1041
    Keywords: metoprolol ; pindolol ; renal haemodynamics ; salt-water handling ; hypertension ; beta-adrenoceptor blockade ; ISA
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The effects on renal hemodynamics and salt-water handling of equipotent doses of the cardioselective β-blocker metoprolol (M, 100 mg) and of the non-selective (intrinsic sympathetic activity) β-antagonist pindolol (P, 10 mg) were compared in 30 WHO Grade 1–2 hypertensive men. M lowered pulse rate more than P. Systolic pressure was equally reduced by both agents, and diastolic and mean pressures were decreased only after P. Glomerular filtration rate was not significantly altered by either antagonist, and renal blood flow decreased by approximately 11% both after M and P. Renal vascular resistance was unchanged after P, and was increased by 10% after M. It is concluded that, like the effects on central haemodynamics, ISA is more important in the renal response to β-adrenoceptor blockade than is β-receptor selectivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00558292
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  • 6
    Electronic Resource
    Electronic Resource
    π0 and η spectra from $$p\bar p$$ annihilations at rest (1984)
    Springer
    The European physical journal 21 (1984), S. 315-319 
    Details
    ISSN: 1434-6052
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The low-energy part of theπ 0 spectrum associated with $$p\bar p$$ annihilation at rest was measured in order to search for bound baryonium-like states. The upper limit for reaching such states via the emission of monochromaticπ 0's was found to be 8% per annihilation in the mass region of 1650 MeV. The low-energy part of the η spectrum from $$p\bar p$$ annihilations at rest was also observed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01581594
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  • 7
    Electronic Resource
    Electronic Resource
    Measurements of γ-γ and γ-electron directional correlations in119Sb (1977)
    Springer
    The European physical journal 283 (1977), S. 357-361 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The directional correlations ofγ-γ andγ-electron cascades in119Sb are measured, in the decay of119mTe. Bothγ-γ andγ-electron directional correlation coefficients are determined for the cascades (energies in keV): 153.5-1212.7, 942.3-270.5, (976.2+979.3)-270.5, 1095.7-270.5 and 1136.8-270.5. For the cascades 912.6-1366.2, 2013.4-270.5 and 2089.9-270.5γ-γ directional correlations are measured. The mixing ratios evaluated are:δ(M2/E1, 153.5 keV)=0.0003±0.0023,δ(E2/M1, 270.5 keV)=-0.39±0.29,δ(E2/M1, 942.3 keV)= −0.26±0.12,δ(E3/M2,1095.7 keV)=−0.01±0.07, andδ(M3/E2,1212.7 keV) =0.004±0.007. The result is compared with theoretical predictions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01409515
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  • 8
    Electronic Resource
    Electronic Resource
    The band structure of the odd-odd166Tm nucleus (1982)
    Springer
    The European physical journal 305 (1982), S. 87-88 
    Details
    ISSN: 1434-601X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The rotational properties of the odd-odd168Tm have been studies by means of the165Ho(α, 3n)166Tm reaction. The existence of five rotational bands has been established.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01415084
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  • 9
    Electronic Resource
    Electronic Resource
    Automated differential scanning calorimetry at low temperatures (1985)
    Springer
    International journal of thermophysics 6 (1985), S. 165-175 
    Details
    ISSN: 1572-9567
    Keywords: antimony ; calorimetry ; differential scanning calorimetry ; low temperature ; specific heat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract A Perkin-Elmer DSC-2 scanning calorimeter was operated by means of a PDP-11/34 computer with time-shared scanner and voltmeter. Special attention was paid to the problems of measurement below room temperature down to the low-temperature limit. It was found that Ne, rather than He, should be used as a purge gas, that scans should always be started at a standardized liquid nitrogen level, and that gas flow to the dry box should be stopped during measurements. Results on benzoic acid were then accurate to 0.6 % from 120 to 300 K. The specific heat of antimony was measured in the temperature interval 120–720 K.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00500029
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  • 10
    Electronic Resource
    Electronic Resource
    Isothermal enthalpy relaxation of glycerol (1987)
    Springer
    International journal of thermophysics 8 (1987), S. 351-362 
    Details
    ISSN: 1572-9567
    Keywords: calorimetry ; isothermal enthalpy relaxation ; glycerol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The isothermal enthalpy relaxation of glycerol has been measured at 13 different annealing times at temperatures of 170, 175, 180, and 185 K. The glasses were formed by linear cooling at 0.667 and 0.083 K·s−1 in a differential scanning calorimeter (DSC). The Williams-Watts relaxation function was fitted to data of enthalpy versus time. A strong temperature dependence was found for the relaxation time. The distribution parameter, β, showed an increase from 0.49 at 170 K to 0.65 at 185 K. We also found indications of an enthalpy dependence in β. Comparison with a theory of volume relaxation showed differences between rates of volume and enthalpy relaxation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00503947
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