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  • 1
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    Anaerobic microbes: oxygen detoxification without superoxide dismutase (1999)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1999-10-09
    Description: Superoxide reductase from the hyperthermophilic anaerobe Pyrococcus furiosus uses electrons from reduced nicotinamide adenine dinucleotide phosphate, by way of rubredoxin and an oxidoreductase, to reduce superoxide to hydrogen peroxide, which is then reduced to water by peroxidases. Unlike superoxide dismutase, the enzyme that protects aerobes from the toxic effects of oxygen, SOR does not catalyze the production of oxygen from superoxide and therefore confers a selective advantage on anaerobes. Superoxide reductase and associated proteins are catalytically active 80 degrees C below the optimum growth temperature (100 degrees C) of P. furiosus, conditions under which the organism is likely to be exposed to oxygen.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jenney, F E Jr -- Verhagen, M F -- Cui, X -- Adams, M W -- New York, N.Y. -- Science. 1999 Oct 8;286(5438):306-9.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Biochemistry and Molecular Biology, Center for Metalloenzyme Studies, University of Georgia, Athens, GA 30602-7229, USA.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/10514376" target="_blank"〉PubMed〈/a〉
    Keywords: Acetylation ; Amino Acid Sequence ; Anaerobiosis ; Bacteria, Anaerobic/enzymology/genetics ; Catalysis ; Cytochrome c Group/metabolism ; Hydrogen Peroxide/metabolism ; Molecular Sequence Data ; NADP/metabolism ; Oxidation-Reduction ; Oxidoreductases/chemistry/genetics/isolation & purification/*metabolism ; Pyrococcus/*enzymology/genetics ; Rubredoxins/metabolism ; Superoxide Dismutase/metabolism ; Superoxides/*metabolism ; Temperature ; Water/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Infectious disease. How a virus travels the world (2015)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 2015-02-07
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Verhagen, Josanne H -- Herfst, Sander -- Fouchier, Ron A M -- New York, N.Y. -- Science. 2015 Feb 6;347(6222):616-7. doi: 10.1126/science.aaa6724. Epub 2015 Feb 5.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Department of Viroscience, Erasmus Medical Center, 3015 CE Rotterdam, Netherlands.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/25657235" target="_blank"〉PubMed〈/a〉
    Keywords: *Animal Migration ; Animals ; Animals, Wild/*virology ; Asia/epidemiology ; Europe/epidemiology ; HN Protein/genetics ; Humans ; Influenza A virus/classification/genetics/*isolation & purification ; Influenza Vaccines/administration & dosage ; Influenza in Birds/*epidemiology/*transmission ; Influenza, Human/*epidemiology/prevention & control/*transmission ; Poultry/*virology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Recent natural selection causes adaptive evolution of an avian polygenic trait (2017)
    American Association for the Advancement of Science (AAAS)
    In: Science
    Details
    Publication Date: 2017-10-20
    Description: We used extensive data from a long-term study of great tits ( Parus major ) in the United Kingdom and Netherlands to better understand how genetic signatures of selection translate into variation in fitness and phenotypes. We found that genomic regions under differential selection contained candidate genes for bill morphology and used genetic architecture analyses to confirm that these genes, especially the collagen gene COL4A5 , explained variation in bill length. COL4A5 variation was associated with reproductive success, which, combined with spatiotemporal patterns of bill length, suggested ongoing selection for longer bills in the United Kingdom. Last, bill length and COL4A5 variation were associated with usage of feeders, suggesting that longer bills may have evolved in the United Kingdom as a response to supplementary feeding.
    Keywords: Evolution
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Geosciences , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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